Results 351 to 360 of about 553,059 (371)
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A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines
Nature Neuroscience, 2021Martin S. Helm +10 more
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Dendritic spine morphogenesis and plasticity
Journal of Neurobiology, 2005AbstractDendritic spines are small protrusions off the dendrite that receive excitatory synaptic input. Spines vary in size, likely correlating with the strength of the synapses they form. In the developing brain, spines show highly dynamic behavior thought to facilitate the formation of new synaptic contacts.
Lippman-Bell, Jocelyn, Dunaevsky, A.
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Structure and Function of Dendritic Spines
Annual Review of Physiology, 2002▪ Abstract Spines are neuronal protrusions, each of which receives input typically from one excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling systems essential for synaptic function and plasticity. Numerous brain disorders are associated with abnormal dendritic spines.
Bernardo L. Sabatini +2 more
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Electrical Compartmentalization in Dendritic Spines [PDF]
Annual Review of Neuroscience, 2013 Most excitatory inputs in the CNS contact dendritic spines, avoiding dendritic shafts, so spines must play a key role for neurons. Recent data suggest that, in addition to enhancing connectivity and isolating synaptic biochemistry, spines can behave as electrical compartments independent from their parent dendrites. It is becoming clear that, although
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On the electrical function of dendritic spines
Trends in Neurosciences, 2004Dendritic spines mediate most excitatory inputs in the brain, yet their function is still unclear. Imaging experiments have demonstrated their role in biochemical compartmentalization at individual synapses, yet theoretical studies have suggested that they could serve an electrical function in transforming synaptic inputs and transmitting dendritic ...
Rafael Yuste, David Tsay
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Dynamics and pathology of dendritic spines
2005Dendritic spines are key players in information processing in the brain. Changes in spine shape and wholesale spine turnover provide mechanisms for modifying existing synaptic connections and altering neuronal connectivity. Although neuronal cell death in acute and chronic neurodegenerative diseases is clearly an important factor in decline of ...
Shelley Halpain +2 more
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Science, 2001
STKE Changes in the morphology of neuronal dendritic spines are correlated with changes in synaptic plasticity. The cell surface proteoglycan syndecan-2 is clustered at the surface of mature hippocampal neurons and is thought to regulate structural changes of the spines. Now Ethell et al.
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STKE Changes in the morphology of neuronal dendritic spines are correlated with changes in synaptic plasticity. The cell surface proteoglycan syndecan-2 is clustered at the surface of mature hippocampal neurons and is thought to regulate structural changes of the spines. Now Ethell et al.
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Molecular morphogens for dendritic spines
Trends in Neurosciences, 2002Three protein components of the postsynaptic density--Shank, Homer and SPAR--have been found to regulate the structural and molecular organization of dendritic spines. These new studies reveal linkages between receptor complexes, the actin cytoskeleton and signaling molecules that help shape spines.
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Dendritic spines and linear networks
Journal of Physiology-Paris, 2004The function of the cortical microcircuitry is still mysterious. Using a bottom-up analysis based on the biophysics and connectivity of cortical neurons, we propose the hypothesis that the neocortex is essentially a linear integrator of inputs. Dendritic spines would slow the neuron and contribute to linearize input summation.
Rochelle Urban, Rafael Yuste
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Dendritic spines for neuroprotection: a hypothesis
Trends in Neurosciences, 1995Ever since their first description in neurons, dendritic spines could be visualized only in fixed tissue, using high-power light and electron microscopy. Recent studies have been able to measure the free intracellular Ca2+ concentration ([Ca2+]i) in dendritic spines of live neurons, and the results suggest that the spine is an independent cellular Ca2+
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