Results 1 to 10 of about 12,503 (156)

Changes of Gene Expression Patterns of Muscle Pathophysiology-Related Transcription Factors During Denervated Muscle Atrophy [PDF]

Frontiers in Physiology, 2022
Peripheral nerve injury is common, and can lead to skeletal muscle atrophy and dysfunction. However, the underlying molecular mechanisms are not fully understood. The transcription factors have been proved to play a key role in denervated muscle atrophy.
Xiaoming Yang, Xiaoming Yang, Ming Li, Yanan Ji, Yinghao Lin, Lai Xu, Xiaosong Gu, Hualin Sun, Wei Wang, Yuntian Shen, Hua Liu, Jianwei Zhu   +11 more
doaj   +2 more sources

SKP-SC-EVs Mitigate Denervated Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation and Improving Microcirculation [PDF]

Antioxidants, 2021
Denervated muscle atrophy is a common clinical disease that has no effective treatments. Our previous studies have found that oxidative stress and inflammation play an important role in the process of denervated muscle atrophy.
Wei Wang, Dingding Shen, Lilei Zhang, Yanan Ji, Lai Xu, Zehao Chen, Yuntian Shen, Leilei Gong, Qi Zhang, Mi Shen, Xiaosong Gu, Hualin Sun   +11 more
doaj   +2 more sources

Macrophage induces angiogenesis via HIF signaling in denervated muscle following nerve injury [PDF]

Scientific Reports
Skeletal muscle and blood vessels typically maintain independent homeostasis under normal physiological conditions. However, peripheral nerve injury often leads to skeletal muscle denervation, affecting the richly vascularized tissue.
Yurie Sato-Yamada, Meircurius Dwi Condro Surboyo, Andrea L. Rosenkranz, Tomoaki Ujita, Meiwen Fang, Prasiddha Mahardhika EI Fadhlallah, Tomoki Maekawa, Yumiko Sato, Nagako Yoshiba, Takeyasu Maeda   +9 more
doaj   +2 more sources

Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats [PDF]

Einstein (São Paulo), 2021
Objective: To evaluate the effects of photobiomodulation therapy in redox status, angiogenesis marker – vascular endothelial growth factor – and in the functional recovery in denervated muscle. Methods: A total of 32 female Wistar rats underwent a crush
Jéssica Junia Aparecida Cardoso Nascimento, Alex Sander Dias Machado, Giovanna Moura Lamas Della-Santa, Danielle Cristina Fernandes, Marcílio Coelho Ferreira, Gustavo Augusto Pereira Machado, Bruna Carolina Garcia Chaves, Karine Beatriz Costa, Etel Rocha-Vieira, Murilo Xavier Oliveira, Thais Peixoto Gaiad, Ana Paula Santos   +11 more
doaj   +3 more sources

S100A8/S100A9 released by CD11b+Ly6G+ neutrophils activate MerTKhiLy6clo reparative macrophages to delay denervated muscle atrophy [PDF]

Experimental and Molecular Medicine
Strategies to delay the process of denervated muscle atrophy are limited, in part because the microenvironmental function of the target muscle is not well understood.
Yaoxian Xiang, Lei Zhu, Zhenwei Qiu, Zongqi You, Junxi Dai, Lei Xu, Junjian Jiang, Jianguang Xu   +7 more
doaj   +2 more sources

Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation

Frontiers in Physiology, 2020
Although denervated muscle atrophy is common, the underlying molecular mechanism remains unelucidated. We have previously found that oxidative stress and inflammatory response may be early events that trigger denervated muscle atrophy. Isoquercitrin is a
Yuntian Shen, Qiuyu Zhang, Ziwei Huang, Jianwei Zhu, Jiayi Qiu, Wenjing Ma, Xiaoming Yang, Fei Ding, Hualin Sun   +8 more
doaj   +3 more sources

Ficus carica L. Attenuates Denervated Skeletal Muscle Atrophy via PPARα/NF-κB Pathway

Frontiers in Physiology, 2020
Treatment options for denervated skeletal muscle atrophy are limited, in part because the underlying molecular mechanisms are not well understood. Unlike previous transcriptomics studies conducted in rodent models of peripheral nerve injury, in the ...
Junxi Dai, Junxi Dai, Junxi Dai, Yaoxian Xiang, Yaoxian Xiang, Yaoxian Xiang, Da Fu, Lei Xu, Lei Xu, Lei Xu, Junjian Jiang, Junjian Jiang, Junjian Jiang, Jianguang Xu, Jianguang Xu, Jianguang Xu, Jianguang Xu   +16 more
doaj   +3 more sources

Muscle fibre denervation in ageing. [PDF]

Clin Sci (Lond)
Abstract Muscle fibre denervation describes the loss of effective neural input from a motor neuron to one or more muscle fibres. In ageing, denervation is increasingly recognised as an important contributor to progressive declines in muscle strength and functional capacity, yet it remains heterogeneous and difficult to define in ...
Soendenbroe C.
europepmc   +5 more sources

Human-Derived Motor Neuron Progenitor Cell Implantation Rescues Motor Endplates Following Peripheral Nerve Injury [PDF]

Journal of Hand Surgery Global Online
Purpose: Degradation of motor endplates (MEPs) following peripheral nerve injury (PNI) is a major determinant of functional recovery, as prolonged denervation renders target muscles progressively unreceptive to reinnervation.
Luigi P. Gonzales, MD, Chris Lee, BS, Arjun T. Gupta, David J. Wright, MD, Tyler R. Johnston, MD, Sang Ho Yoon, PhD, Robert Hunt, PhD, Oswald Steward, PhD, Ranjan Gupta, MD   +8 more
doaj   +2 more sources

CtBP1 sustains activity-dependent muscle properties and dampens synaptic, contractile and metabolic changes triggered by denervation [PDF]

Skeletal Muscle
Background Denervation triggers dramatic atrophy of skeletal muscle, accompanied by synaptic, contractile and metabolic changes. Several factors were shown to contribute to genetic reprogramming and proteostasis changes after denervation.
Olivia Cattaneo, Gaetan Lopez, Jayasimman Rajendran, Florent Chabry, Nicolas Liaudet, Sergei Startchik, Alexandre Prola, Perrine Castets   +7 more
doaj   +2 more sources