Results 91 to 100 of about 230,109 (316)

Silica Nanoparticles as Multifunctional Platforms for Vaccine Delivery and Immune Modulation in Infectious Diseases

Advanced NanoBiomed Research, EarlyView.
Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez, Julio García‐Cordero, Gabriela Navarro‐Tovar, Leticia Cedillo‐Barrón   +3 more
wiley   +1 more source

Estimating Dengue Outbreak Thresholds in West Africa: A Comprehensive Analysis of Climatic Influences in Burkina Faso, 2018–2024

Tropical Medicine and Infectious Disease
Background: Dengue, transmitted by Aedes spp. mosquitoes, poses significant public health challenges in Burkina Faso. This study investigated outbreak thresholds, utilizing historical data since 2018 to explore the climatic impacts on dengue transmission
John Otokoye Otshudiema, Watton R. Diao, Sonia Marie Wend-Kuuni Ouedraogo, Alain Ngoy Kapete, Laurent Moyenga, Emmanuel Chanda, Tieble Traore, Otim Patrick Ramadan, Alimuddin Zumla   +8 more
doaj   +1 more source

Potential antigenic cross-reactivity between SARS-CoV-2 and Dengue viruses

Clinical Infectious Diseases, 2020
BACKGROUND COVID-19 and dengue fever are difficult to distinguish given shared clinical and laboratory features. Failing to consider COVID-19 due to false-positive dengue serology can have serious implications.
Y. Lustig, S. Keler, Rachel Kolodny, N. Ben-Tal, Danit Atias-Varon, E. Shlush, M. Gerlic, A. Munitz, R. Doolman, K. Asraf, L. Shlush, A. Vivante   +11 more
semanticscholar   +1 more source

Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships

ChemMedChem, EarlyView.
Green chemistry‐based late‐stage functionalization (LSF) of the anti‐proprotein convertase subtilisin/kexin type 9 (PCSK9) early lead compound 5c led to optimized analogs with improved metabolic stability/PCSK9 IC50 ratio. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia ...
Lisa Giannessi, Maria Giovanna Lupo, Martina Ugolotti, Bianca Papotti, Beatrice Mattina, Maria Grazia Martina, Anna Demurtas, Cristina Padula, Sara Nicoli, Marco Crescenzo, Nicola Ferri, Francesca Zimetti, Marco Radi   +12 more
wiley   +1 more source

Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules

Immunity, Inflammation and Disease
Background Pattern recognition receptors (PRRs) are the receptors of the innate immune system that play a vital role in initiating innate immune response.
Meenal Sharma, Priyanka Wagh, Tanvi Shinde, Diptee Trimbake, Anuradha S. Tripathy   +4 more
doaj   +1 more source

Diagnostics for optimised dengue surveillance: a qualitative focus group study to investigate user experience and requirements in Thailand

BMJ Open
Objectives Effective, real-time surveillance of dengue may provide early warning of outbreaks and support targeted disease-control intervention but requires widespread accurate diagnosis and timely case reporting.
Raheelah Ahmad, Alison Holmes, Pantelis Georgiou, Paul Arkell, Sanhapon Ketklao, Adisak Songjaeng, Dumrong Mairiang, Jesus Rodriguez-Manzano, Prida Malasit, Panisadee Avirutnan, Saranath Lawpoolsri   +10 more
doaj   +1 more source

Dengue transmission dynamics prediction by combining metapopulation networks and Kalman filter algorithm

, 2023
Qinghui Zeng, Xiaolin Yu, Haobo Ni, Lina Xiao, Ting Xu, Haisheng Wu, Yuliang Chen, Hui Deng, Yingtao Zhang, Sen Pei, Jianpeng Xiao, Pi Guo   +11 more
openalex   +2 more sources

Powerful yet challenging: mechanistic niche models for predicting invasive species potential distribution under climate change

Ecography, EarlyView.
Risk assessments of invasive species present one of the most challenging applications of species distribution models (SDMs) due to the fundamental issues of distributional disequilibrium, niche changes, and truncation. Invasive species often occupy only a fraction of their potential environmental and geographic ranges, as their spatiotemporal dynamics ...
Erola Fenollosa, Sean E. H. Pang, Natalie J. Briscoe, Antoine Guisan, Roberto Salguero-Gómez   +4 more
wiley   +1 more source

ANTIVIRAL ACTIVITY OF COPPER(II)CHLORIDE DIHYDRATE AGAINST DENGUE VIRUS TYPE-2 IN VERO CELL

Indonesian Journal of Tropical and Infectious Disease, 2017
Infection of dengue virus (DENV) was number of globally significant emerging pathogen. Antiviral dengue therapies ar importantly needed to control emerging dengue.
Teguh Hari Sucipto, Siti Churrotin, Harsasi Setyawati, Tomohiro Kotaki, Fahimah Martak, Soegeng Soegijanto   +5 more
doaj   +1 more source

Global Health Initiatives and Universal Health Coverage in Pakistan‐Aligned for the Future?

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT There is increasing global discourse on Global Health Initiatives' (GHIs) role and the need for better alignment with universal health coverage (UHC), which is particularly salient given recent rapid reductions in global aid. However, tensions within national ecosystems of GHI assistance and country alignment towards UHC are less well ...
Shehla Zaidi, Shifa Salman Habib, Asad Shoaib, Zakir Shah, Karl Blanchet, Rosemary Jouhad, Natasha Palmer, Valery Ridde, Sophie Witter   +8 more
wiley   +1 more source