Results 31 to 40 of about 270,692 (188)

Drug repurposing approach against chikungunya virus: an in vitro and in silico study

Frontiers in Cellular and Infection Microbiology, 2023
The chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes mosquitoes. There are no licenced antivirals or vaccines for treatment or prevention. Drug repurposing approach has emerged as a novel concept to find alternative uses of therapeutics to
Bhagyashri Kasabe, Gunwant Ahire, Poonam Patil, Madhura Punekar, Kusuma Sai Davuluri, Mahadeo Kakade, Kalichamy Alagarasu, Deepti Parashar, Sarah Cherian   +8 more
doaj   +1 more source

Aminotransferase changes and acute hepatitis in patients with dengue fever: analysis of 1,585 cases

Brazilian Journal of Infectious Diseases
INTRODUCTION: Type 3 dengue virus caused an extensive epidemic in the state of Rio de Janeiro in summer 2002. In some of the patients, it was found in an atypical form with increased aminotransferase levels and acute hepatitis.
Luiz José de Souza, José Galvão Alves, Rita Maria Ribeiro Nogueira, Carlos Gicovate Neto, Diogo Assed Bastos, Edno Wallace da Silva Siqueira, João Tadeu Damian Souto Filho, Thiago de Abreu Cezário, Carlos Eduardo Soares, Rodrigo da Costa Carneiro   +9 more
doaj   +1 more source

Cost of intensive routine control and incremental cost of insecticide-treated curtain deployment in a setting with low Aedes aegypti infestation [PDF]

, 2016
Introduction: Information regarding the cost of implementing insecticide-treated curtains (ITCs) is scarce. Therefore, we evaluated the ITC implementation cost, in addition to the costs of intensive conventional routine activities of the Aedes control ...
Baly Gil, Alberto, Benítez, Elizabeth, Lambert, Isora, Rodriguez, Esther, Rodriguez, Karina, Toledo Romani, Maria Eugenia, Van Der Stuyft, Patrick, VANLERBERGHE, VEERLE   +7 more
core   +2 more sources

Comparison of clinical and laboratory characteristics between children and adults with dengue

Brazilian Journal of Infectious Diseases
Over the past several years, the epidemiological profile of dengue has been changing progressively and is currently characterized by an increase in the number of cases in children under 15 years of age.
Luiz José de Souza, Laís Bastos Pessanha, Laura Carvalho Mansur, Luiza Assed de Souza, Mariana Barbosa Tâmega Ribeiro, Monique do Vale da Silveira, João Tadeu Damian Souto Filho   +6 more
doaj   +1 more source

Predictive value of persistent NS1 antigen positivity beyond 3rd day for dengue haemorrhagic fever in Sri Lankan children

BMC Research Notes, 2019
Objective Dengue haemorrhagic fever (DHF) is a major public health concern responsible for significant morbidity in both adult and paediatric populations in Sri Lanka.
Mihira Manamperi, Bernard Deepal Wanniarachchi Jayamanne, Thilini Somaratne, Natasha Perera, LakKumar Fernando   +4 more
doaj   +1 more source

Integrated vector control of Aedes aegypti mosquitoes around target houses

Parasites & Vectors, 2018
Background The developing fetuses of pregnant women are at high risk of developing serious birth defects following Zika virus infections. We applied an Integrated Vector Control (IVC) approach using source reduction, larviciding, and mass trapping with ...
Roberto Barrera, Manuel Amador, Jorge Munoz, Veronica Acevedo   +3 more
doaj   +1 more source

The complex relationship between weather and dengue virus transmission in Thailand. [PDF]

, 2013
Using a novel analytical approach, weather dynamics and seasonal dengue virus transmission cycles were profiled for each Thailand province, 1983-2001, using monthly assessments of cases, temperature, humidity, and rainfall.
Campbell, Karen M, Iamsirithaworn, Sopon, Lin, CD, Scott, Thomas W   +3 more
core   +1 more source

Dengue and dengue haemorrhagic fever

The Lancet, 1998
The incidence and geographical distribution of dengue have greatly increased in recent years. Dengue is an acute mosquito-transmitted viral disease characterised by fever, headache, muscle and joint pains, rash, nausea, and vomiting. Some infections result in dengue haemorrhagic fever (DHF), a syndrome that in its most severe form can threaten the ...
Rigau-Pérez, J, Clark, G, Gubler, D, Reiter, P, Sanders, E, Vorndam, A   +5 more
openaire   +2 more sources

A Transcriptomics-Based Bioinformatics Approach for Identification and In Vitro Screening of FDA-Approved Drugs for Repurposing against Dengue Virus-2

Viruses, 2022
The rising incidence of dengue virus (DENV) infections in the tropical and sub-tropical regions of the world emphasizes the need to identify effective therapeutic drugs against the disease.
Madhura Punekar, Bhagyashri Kasabe, Poonam Patil, Mahadeo B. Kakade, Deepti Parashar, Kalichamy Alagarasu, Sarah Cherian   +6 more
doaj   +1 more source

Association of dengue virus‐specific polyfunctional T‐cell responses with clinical disease severity in acute dengue infection

Immunity, Inflammation and Disease, 2019
Introduction Although the role of dengue virus (DENV)‐specific T cells in the pathogenesis of acute dengue infection is emerging, the functionality of virus‐specific T cells associated with milder clinical disease has not been well studied.
Dulharie T. Wijeratne, Samitha Fernando, Laksiri Gomes, Chandima Jeewandara, Geethal Jayarathna, Yashoda Perera, Samurdhi Wickramanayake, Ananda Wijewickrama, Graham S. Ogg, Gathsaurie N. Malavige   +9 more
doaj   +1 more source