Results 41 to 50 of about 178,253 (288)

Is diabetes a risk factor for a severe clinical presentation of dengue? Review and meta-analysis [PDF]

, 2015
BACKGROUND: The mean age of acute dengue has undergone a shift towards older ages. This fact points towards the relevance of assessing the influence of age-related comorbidities, such as diabetes, on the clinical presentation of dengue episodes ...
Valérie D'Acremont, Eze, I. C., Probst-Hensch, N., Eze, I.C., Nan Shwe Nwe Htun, Ikenna C. Eze (729620), Odermatt, P., Ikenna C Eze, Htun, N.S., Boillat-Blanco, N., Htun, N. S., Nicole Probst-Hensch (520032), Peter Odermatt, Peter Odermatt (148926), D'Acremont, V., Nicole Probst-Hensch, Noémie Boillat-Blanco (729621), Valérie D’Acremont (729622), Nan Shwe Nwe Htun (729619), Noémie Boillat-Blanco   +19 more
core   +1 more source

Dengue in Bangladesh

IJID One Health, 2023
Dengue is one of the prominent public health concerns in tropical and subtropical regions globally. The dengue epidemic was first observed in the 1780s, mainly in Asia, Africa, and America; however, this virus was found in Bangladesh in 1964. Rapid and unplanned urbanization, global warming, and prolonged rainy season promoted dengue outbreaks in ...
Atia Sharmin, Bonna, Shahed Rafi, Pavel, Tajnuva, Mehjabin, Mohammad, Ali   +3 more
openaire   +2 more sources

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Association of dengue virus‐specific polyfunctional T‐cell responses with clinical disease severity in acute dengue infection

Immunity, Inflammation and Disease, 2019
Introduction Although the role of dengue virus (DENV)‐specific T cells in the pathogenesis of acute dengue infection is emerging, the functionality of virus‐specific T cells associated with milder clinical disease has not been well studied.
Dulharie T. Wijeratne, Samitha Fernando, Laksiri Gomes, Chandima Jeewandara, Geethal Jayarathna, Yashoda Perera, Samurdhi Wickramanayake, Ananda Wijewickrama, Graham S. Ogg, Gathsaurie N. Malavige   +9 more
doaj   +1 more source

RNA Isolation of Dengue Virus Type 2 with Different Precipitation Solvents : Methanol, Chloroform, and 2-Isopropanol.

Jurnal Kimia Riset, 2018
Dengue virus distributed in tropical and subtropical regions in the world. DENV viruses are transmitted between humans primarily by Aedes aegypti and Aedes albopictus mosquitoes and are endemic in most areas in which the vectors occur.
Yovilianda Maulitiva Untoro, Teguh Hari Sucipto, Harsasi Setyawati, Siti Churrotin, Ilham Harlan Amarullah, Puspa Wardhani, Aryati Aryati, Shuhai Ueda, Soegeng Soegijanto   +8 more
doaj   +1 more source

A Transcriptomics-Based Bioinformatics Approach for Identification and In Vitro Screening of FDA-Approved Drugs for Repurposing against Dengue Virus-2

Viruses, 2022
The rising incidence of dengue virus (DENV) infections in the tropical and sub-tropical regions of the world emphasizes the need to identify effective therapeutic drugs against the disease.
Madhura Punekar, Bhagyashri Kasabe, Poonam Patil, Mahadeo B. Kakade, Deepti Parashar, Kalichamy Alagarasu, Sarah Cherian   +6 more
doaj   +1 more source

Dengue

Jornal de Pediatria, 1999
OBJECTIVE: To review the literature about epidemiological, clinical and preventive aspects of hemorrhagic dengue fever in children, and to provide Brazilian pediatricians with an update on dengue METHODS: We reviewed MEDLINE and classic texts.RESULTS: Dengue is an arbovirus disease, transmitted by Aedes aegypti, a mosquito that feeds indoors and is ...
openaire   +2 more sources

Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression [PDF]

, 2005
Type 1 interferons (IFN-?/?) are key mediators of innate antiviral responses but havelittle effect on established replication of dengue viruses, which are mosquito-borneflaviviruses of immense global health importance.
Jones, M, Jacobs, M, Ball, S, Hibbert, L, Foster, G, Davidson, AD, Foster, GR, Davidson, A, Gruenwald, P, Schlaak, J   +9 more
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Corticosteroids for dengue - why don't they work? [PDF]

, 2013
BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47 ...
Tuan Trung Vu, Cameron P. Simmons, Thi Hanh, Simmons, Cameron, Simmons, C, Tuan Trung Vu (496520), Thi Hoai, Martin L. Hibberd, Wills, B, Nguyen, Than Ha Quyen, Whitehead, SS, Martin L Hibberd, Dong, TH, Vu, TT, Phung, Khanh Lam, Stephen S. Whitehead, Bridget Wills (74672), Khanh Lam Phung, Wills, Bridget, Thi Hanh Tien Nguyen, Quyen Nguyen, Phung, KL, Van Ngoc Tran, Tien Nguyen, Van Ngoc Tran (496523), Farrar, J, Ngoc Tran, Van, Farrar, Jeremy, Hoang, TL, Jeremy Farrar, Nguyen, TH, Ngoc Tran, V, Stephen S. Whitehead (150702), Dong, Thi Hoai Tam, Nguyen, Thi Hanh Tien, Than Ha Quyen Nguyen (496519), Wolbers, M, Thi Hoai Tam Dong (496522), Jeremy Farrar (74677), Vu, Tuan Trung, Simmons, CP, Thi Hoai Tam Dong, Tam Dong, Whitehead, Stephen S, Marcel Wolbers, Marcel Wolbers (33689), Simmons, Cameron P, Than Ha, Than Ha Quyen Nguyen, Stephen S Whitehead, Hibberd, ML, Wolbers, Marcel, Bridget Wills, Khanh Lam Phung (496524), Cameron P Simmons, Cameron P. Simmons (117211), Martin L. Hibberd (167212), Hoang, Truong Long, Hibberd, Martin L, Truong Long Hoang, Thi Hanh Tien Nguyen (496518), Truong Long Hoang (496521)   +61 more
core   +2 more sources