Results 61 to 70 of about 178,253 (288)

Towards understanding of the replication and pathogenesis of dengue infection [PDF]

, 2007
Dengue is the most important human viral disease transmitted by arthropod vectors and over half of the world's population live in areas at risk of infection. Currently there is neither specific treatment nor vaccine to tackle this emerging disease. The
Umareddy, Indira
core   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

The early clinical features of dengue in adults: challenges for early clinical diagnosis. [PDF]

, 2011
BACKGROUND: The emergence of dengue throughout the tropical world is affecting an increasing proportion of adult cases. The clinical features of dengue in different age groups have not been well examined, especially in the context of early clinical ...
Chaterji, S., Lee-Ching Ng, Martin L. Hibberd, Chow, Angelia, Sharon W. S. Tan, Chua, C.R., Vasudevan Subhash G., Martin L Hibberd, Ooi Eng Eong, Leo Yee Sin, Choon Rong Chua, Chua Robert, Vasudevan, Subhash G, Chaterji, Shera, Leo, Yee Sin, Cheung, Yin Bun, Ng, Lee-Ching, Leo, Y.S., Chow, A., Ong Adrian, Cheung Yin Bun, Lim Wen Yan, Yin Bun Cheung, Chua Choon Rong, Adrian Ong, Yee Sin Leo, Low, Jenny GH, Hibberd, M.L., Subhash G Vasudevan, Low Jenny G. H., Ong, A., Cheung, Y.B., Ooi, E.E., Ng, L.-C., Low, J.G.H., Vasudevan, S.G., Jenny G. H. Low, Hibberd Martin L., Wen Yan Lim, Eng Eong Ooi, Tan Li Kiang, Lee, K.W., Jenny G H Low, Ong, Adrian, Lim, W.Y., Shera Chaterji, Chua, R., Koon Wui Lee, Tan Sharon W. S., Lim, Wen Yan, Ng Lee-Ching, Subhash G. Vasudevan, Lee Koon Wui, Robert Chua, Chaterji Shera, Ooi, Eng Eong, Hibberd, Martin L, Tan, L.K., Tan, S.W.S., Angelia Chow, Li Kiang Tan, Lee, Koon Wui, Tan, Sharon WS, Tan, Li Kiang, Sharon W S Tan, Chua, Choon Rong, Chua, Robert, Chow Angelia   +67 more
core   +2 more sources

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Serotype and genotype diversity of dengue viruses circulating in India: a multi-centre retrospective study involving the Virus Research Diagnostic Laboratory Network in 2018

International Journal of Infectious Diseases, 2021
: Objectives: A retrospective study was undertaken to investigate the circulating dengue virus (DENV) serotypes and genotypes in India in 2018. Methods: In total, 4963 samples referred to virus research diagnostic laboratories (n=21), the Indian Council
K. Alagarasu, J.A. Patil, M.B. Kakade, A.M. More, B. Yogesh, P. Newase, S.M. Jadhav, D. Parashar, H. Kaur, N. Gupta, N. Vijay, J. Narayan, P.S. Shah, Dr Ajanta Sharma, Dr Amita Jain, Dr Anudita Bhargava, Dr B. Anukumar, Dr Ashok M, Dr Bharti Malhotra, Dr B.J. Borkakoty, Dr Debasis Biswas, Dr SC Jaryal, Dr Kanwardeep Singh Dhingra, Dr K. Kaveri, Dr P.K. Khatri, Dr Manoj Kumar, Dr K. Nagamani, Dr Rahul Dhodapkar, Dr Rupinder Bakshi, Dr Paramjeet S. Gill, Dr Sanghamitra Pati, Dr Shanta Dutta, Dr Shantala G, Dr Usha Kalawat, Dr Disha A. Patel, Dr P. Vijayachari   +35 more
doaj   +1 more source

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study

Virology Journal
Chikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of the disease.
Kusuma Sai Davuluri, Rajnandini Ghanghav, Gunwant Ahire, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar   +6 more
doaj   +1 more source

INHIBITORY ACTIVITY OF COBALT(II)–MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2

Indonesian Journal of Tropical and Infectious Disease, 2017
Dengue virus (DENV) is a significant pathogen emerging worldwide as a cause of infectious disease. Antidengue treatments are urgently required to control the emergence of dengue.
Teguh Hari Sucipto, Siti Churrotin, Harsasi Setyawati Setyawati, Kris Cahyo Mulyatno, Ilham Harlan Amarullah, Shuhai Ueda, Tomohiro Kotaki, Sri Sumarsih, Puspa Wardhani, Sri Subekti Bendryman, Aryati Aryati, Soegeng Soegijanto, Masanori Kameoka   +12 more
doaj   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

FEVER AS INDICATOR TO SECONDARY INFECTION IN DENGUE VIRAL INFECTION

Indonesian Journal of Tropical and Infectious Disease, 2018
Dengue Virus Infections are distributed in tropical and sub-tropical regions and transmitted by the mosquitoes such as Aedes aegypti and Aedes albopictus.
Soegeng Soegijanto, Sufiandika Nuryandari, Siti Churrotin, Teguh Hari Sucipto   +3 more
doaj   +1 more source