Results 61 to 70 of about 152,116 (307)

Key Amino Acid Substitution for Infection-Enhancing Activity-Free Designer Dengue Vaccines

iScience, 2019
Summary: Dengue is a globally important disease caused by four serotypes of dengue virus. Dengue vaccine development has been hampered by antigenic cross-reactivity among serotypes, which potentially causes antibody-dependent enhancement of infection and
Atsushi Yamanaka, Eiji Konishi
doaj   +1 more source

A clustered regularly interspaced palindromic repeat‐Cas12a‐based assay for rapid dengue virus monitoring in mosquito and clinical samples facilitating global collaborative surveillance and risk assessment to block dengue spreading

Interdisciplinary Medicine, EarlyView.
The RAA‐Cas12a assay outperforms real‐time PCR in sensitivity (92.3%) while matching its specificity (100%) for dengue virus detection in clinical samples. It effectively identifies DENV in mosquitoes, with field data correlating to local outbreaks. This rapid, simple, and precise method serves as an early warning tool for dengue management.
Xiang Guo, Minling Hu, Ying Lu, Xiaohua Liu, Haiyang Chen, Xiaoqing Zhang, Liu Ge, Ziyao Li, Yuji Wang, Qing He, Shu Zeng, Wenwen Ren, Lingzhai Zhao, Zhiqiang Peng, Wushen Chen, Chunmei Wang, Qingming Kong, Shaohong Lu, Fuchun Zhang, Lei Luo, Hua Li, Xiao‐Guang Chen, Xiaohong Zhou   +22 more
wiley   +1 more source

Dengue [PDF]

New England Journal of Medicine, 2012
Simmons, C, Farrar, J, Nguyen, V, Wills, B   +3 more
openaire   +5 more sources

Estimating Dengue Outbreak Thresholds in West Africa: A Comprehensive Analysis of Climatic Influences in Burkina Faso, 2018–2024

Tropical Medicine and Infectious Disease
Background: Dengue, transmitted by Aedes spp. mosquitoes, poses significant public health challenges in Burkina Faso. This study investigated outbreak thresholds, utilizing historical data since 2018 to explore the climatic impacts on dengue transmission
John Otokoye Otshudiema, Watton R. Diao, Sonia Marie Wend-Kuuni Ouedraogo, Alain Ngoy Kapete, Laurent Moyenga, Emmanuel Chanda, Tieble Traore, Otim Patrick Ramadan, Alimuddin Zumla   +8 more
doaj   +1 more source

Optimizing the deployment of ultra-low volume and targeted indoor residual spraying for dengue outbreak response [PDF]

, 2020
Sean Cavany, Guido España, Alun L. Lloyd, Lance A. Waller, Uriel Kitron, Helvio Astete, William H. Elson, Gonzalo M. Vazquez‐Prokopec, Thomas W. Scott, Amy C. Morrison, Robert C. Reiner, T. Alex Perkins   +11 more
openalex   +1 more source

Analysis of Gene Expression in Aedes aegypti Suggests Changes in Early Genetic Control of Mosquito Development

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
ABSTRACT Aedes aegypti, a critical vector for tropical diseases, poses significant challenges for studying its embryogenesis due to difficulties in removing its rigid chorion and achieving effective fixation for in situ hybridization. Here, we present novel methodologies for fixation, dechorionation, DAPI staining, and in situ hybridization, enabling ...
Renata Coutinho‐dos‐Santos, Danielle Santos, Lupis Ribeiro, Jonathan J. Mucherino‐Muñoz, Marcelle Uhl, Carlos Logullo, A. Mendonça‐Amarante, M. Fantappie, Rodrigo Nunes‐da‐Fonseca   +8 more
wiley   +1 more source

Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules

Immunity, Inflammation and Disease
Background Pattern recognition receptors (PRRs) are the receptors of the innate immune system that play a vital role in initiating innate immune response.
Meenal Sharma, Priyanka Wagh, Tanvi Shinde, Diptee Trimbake, Anuradha S. Tripathy   +4 more
doaj   +1 more source

RNAi-Induced Gene Silencing against Chikungunya and COVID-19: What Have We Learned So Far, and What Is the Way Forward?

Viruses
RNA interference (RNAi) is a process in which small RNA molecules (such as small interfering RNAs or siRNAs) bind to specific messenger RNAs (mRNAs), leading to its degradation and inhibition of protein synthesis.
Kingshuk Panda, Kalichamy Alagarasu, Rajarshee Tagore, Mandar Paingankar, Satyendra Kumar, Manish Kumar Jeengar, Sarah Cherian, Deepti Parashar   +7 more
doaj   +1 more source

Multiple introductions of dengue virus strains contribute to dengue outbreaks in East Kalimantan, Indonesia, in 2015–2016

Virology Journal, 2019
Background Dengue fever is a febrile disease caused by dengue virus (DENV), which affects people throughout the tropical and subtropical regions of the world, including Indonesia.
R. Tedjo Sasmono, Lily Pertiwi Kalalo, Suryani Trismiasih, Dionisius Denis, Benediktus Yohan, Rahma F. Hayati, Sotianingsih Haryanto   +6 more
doaj   +1 more source

Dengue encephalitis

Indian Journal of Critical Care Medicine, 2011
We report a case of dengue fever with features of encephalitis. The diagnosis of dengue was confirmed by the serum antibodies to dengue and the presence of a dengue antigen in the cerebrospinal fluid. This patient had characteristic magnetic resonance imaging brain findings, mainly involving the bilateral thalami, with hemorrhage.
Borawake, Kapil, Prayag, Parikshit, Wagh, Atul, Dole, Swati   +3 more
openaire   +3 more sources