Results 91 to 100 of about 436,511 (214)

Use of Dried Blood Spots for Identifying Hepatitis E Infections in an Outbreak Setting

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Accurate and accessible diagnostics for hepatitis E virus (HEV) are essential for outbreak preparedness and surveillance, particularly in low‐resource settings. Dried blood spots (DBS) are a scalable alternative to serum, but their diagnostic performance for HEV remains poorly characterised.
Catia Alvarez, Robin Nesbitt, Kinya Vincent Asilaza, Pascale Sattonnet‐Roche, Joseph Wamala, Shimul Das, Melat Haile, Monica Rull, Etienne Gignoux, Manuel Albela, John Rumunu, Isabella Eckerle, Iza Ciglenecki, Andrew S. Azman, Benjamin Meyer   +14 more
wiley   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

17‐epi‐Melianodiol, a new protolimonoid from Melia azedarach fruits, exhibits larvicidal activity and is associated with oxidative imbalance and midgut epithelial damage in Aedes aegypti larvae

Pest Management Science, Volume 82, Issue 9, Page 9240-9248, September 2026.
The bio‐guided phytochemical study resulted in the new compound 17‐epi‐melianodiol. The compound eliminated 100% of Aedes aegypti larvae at 100 ppm, causing pronounced morphological changes, cuticular damage, and extensive vacuolization. Abstract BACKGROUND In Brazil, Aedes aegypti is the primary vector of arboviruses such as dengue, chikungunya ...
Kethleen Duarte Crespo Soares, Thalya Soares Ribeiro Nogueira, Maria Aparecida Aride Bertonceli, Renata Rodrigues da Silva Robaina, Leticia Oliveira da Rocha, Francisco José Alves Lemos, Kátia Valevski Sales Fernandes, Raimundo Braz‐Filho, Ivo José Curcino Vieira   +8 more
wiley   +1 more source

Dengue Vaccines: Current Status and Future Perspectives

APIK Journal of Internal Medicine
Dengue fever (DF), caused by the dengue virus (DENV), is a major public health problem worldwide, with approximately 390 million reported annual infections.
Vasantha Kamath, A. B. Aishwarya
doaj   +1 more source

The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria, Francesco Branda, Giancarlo Ceccarelli, Fabio Scarpa, Massimo Ciccozzi, Alessandro Russo   +5 more
wiley   +1 more source

Advances in prevention and control for dengue fever

Di-san junyi daxue xuebao, 2019
Dengue fever is an acute infectious disease caused by mosquito vector bites carrying dengue virus. Dengue fever has been prevalent in more than 100 countries and regions, with about 390 million people infected each year.
LI Jintao
doaj   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Feasibility of case-control and test-negative designs to evaluate dengue vaccine effectiveness in Malaysia [PDF]

, 2019
Background: The world's first dengue vaccine [Dengvaxia; Sanofi Pasteur] was licensed in 2015 and others are in development. Real-world evaluations of dengue vaccines will therefore soon be needed.
Lim, Wei Yin, Junus, Suria, Linus Lojikip, Sharon, HSS, Amar Singh, Kumar, Suresh, Nealon, Joshua, Nachiappan, Jeyaseelan P., Moureau, Annick, Devi Sekaran, Shamala, Ochiai, R. Leon, Radigue, Cedric, Cowling, Benjamin J.   +11 more
core   +1 more source

Dengue update [PDF]

CDC\ue2\u20ac\u2122s Dengue Branch in Puerto Rico is the largest single dengue research and response unit in the world.Dengue in Key West, Florida -- New Dengue Branch chief -- Dengue is now a reportable disease in the United States -- Early dengue ...

core   +2 more sources

Design and Synthesis of a Potent, Cell Active Purine‐Based Amidoxime Against the Dengue Virus

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Scaffold hopping from our previous indolazepinone hit exemplifies purine SP‐835G with DENV2 EC50 0.1 µM, CC50>100 µM, clogP 3.61. Docking studies support its amidine metabolite operates as an allosteric inhibitor of DENV(pro). A flexible ether linker appears pivotal for enhancing binding and activity.
Dimitrios Kiousis, Despoina Giannioti, Georgia Kalyva, Vasiliki Zogali, Maharah Binte Abdul Mahid, Kitti Wing Ki Chan, Minos‐Timotheos Matsoukas, Subhash G. Vasudevan, Gerasimos Rassias   +8 more
wiley   +1 more source