Results 71 to 80 of about 436,511 (214)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

open access: yesAdvanced Science, Volume 13, Issue 51, 14 September 2026.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du   +9 more
wiley   +1 more source

Refined efficacy estimates of the Sanofi Pasteur dengue vaccine CYD-TDV using machine learning

open access: yesNature Communications, 2018
Clinical trials for the CYD-TDV dengue vaccine showed that vaccine efficacy varies with prior dengue exposure, but baseline serostatus is only known for 12% of subjects. Here, Dorigatti et al.
I. Dorigatti   +6 more
doaj   +1 more source

The Baboon as a Model to Study Human Health and Complex Disease

open access: yesAmerican Journal of Primatology, Volume 88, Issue 9, September 2026.
Baboons remain underappreciated as models of human biology and disease offering a distinct combination of biological and practical properties. In this review, we evaluate the baboon as a model for human complex diseases and make the case for broader use of baboons in translational research.
Brittany Hazzard, Yoav Gilad
wiley   +1 more source

Development of dengue vaccine by using plga microparticle adsorbed with dengue subunit protein

open access: yes, 2016
[[abstract]]Aims: Poly lactic-co-glycolic acid (PLGA) is a biocompatible and biodegradable material used in many biomedical applications, including bioactive agent delivery.
Pan, CH;Hsieh, CH
core   +1 more source

Risk Factors for Mortality in Dengue Shock Syndrome (DSS) [PDF]

open access: yes, 2009
Background: Dengue shock syndrome (DSS) is the most severe form of dengue hemorrhagic fever (DHF) and has a high mortality. There are two major pathological changes in DHF determining the severity of disease, plasma leakage and bleeding.
Djokomoeljanto, Robert J   +6 more
core   +1 more source

Dengue vaccine acceptance and willingness to pay

open access: yesHuman Vaccines & Immunotherapeutics, 2017
The introduction of new vaccines is accompanied by a variety of challenges. Among these, very important ones concern the questions whether the public is willing to accept and willing to purchase the vaccine.
Harapan Harapan   +3 more
doaj   +1 more source

Anti-dengue Vaccines: From Development to Clinical Trials

open access: yesFrontiers in Immunology, 2020
Dengue Virus (DENV) is an arbovirus (arthropod-borne virus). Four serotypes of DENV are responsible for the infectious disease called dengue that annually affects nearly 400 million people worldwide.
Josilene Ramos Pinheiro-Michelsen   +9 more
doaj   +1 more source

Metabolic Footprint of Drosophila S2 Cells: Findings During the Production of a Recombinant Rabies Virus Glycoprotein

open access: yesBiotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary To further increase protein expression, it is imperative to improve cellular performance, a process intrinsically linked to cell metabolism. Hence, a metabolic footprint of Drosophila S2 cells, both recombinant‐ and wild‐types, was performed to enhance the production of the recombinant rabies virus glycoprotein ...
Monize Caiado Decarli   +6 more
wiley   +1 more source

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