Results 71 to 80 of about 436,511 (214)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Dengue vaccine : evidence to recommendations framework [PDF]
02-Dengue-Paz-Bailey-508 ...
core +2 more sources
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du +9 more
wiley +1 more source
Refined efficacy estimates of the Sanofi Pasteur dengue vaccine CYD-TDV using machine learning
Clinical trials for the CYD-TDV dengue vaccine showed that vaccine efficacy varies with prior dengue exposure, but baseline serostatus is only known for 12% of subjects. Here, Dorigatti et al.
I. Dorigatti +6 more
doaj +1 more source
The Baboon as a Model to Study Human Health and Complex Disease
Baboons remain underappreciated as models of human biology and disease offering a distinct combination of biological and practical properties. In this review, we evaluate the baboon as a model for human complex diseases and make the case for broader use of baboons in translational research.
Brittany Hazzard, Yoav Gilad
wiley +1 more source
Development of dengue vaccine by using plga microparticle adsorbed with dengue subunit protein
[[abstract]]Aims: Poly lactic-co-glycolic acid (PLGA) is a biocompatible and biodegradable material used in many biomedical applications, including bioactive agent delivery.
Pan, CH;Hsieh, CH
core +1 more source
Risk Factors for Mortality in Dengue Shock Syndrome (DSS) [PDF]
Background: Dengue shock syndrome (DSS) is the most severe form of dengue hemorrhagic fever (DHF) and has a high mortality. There are two major pathological changes in DHF determining the severity of disease, plasma leakage and bleeding.
Djokomoeljanto, Robert J +6 more
core +1 more source
Dengue vaccine acceptance and willingness to pay
The introduction of new vaccines is accompanied by a variety of challenges. Among these, very important ones concern the questions whether the public is willing to accept and willing to purchase the vaccine.
Harapan Harapan +3 more
doaj +1 more source
Anti-dengue Vaccines: From Development to Clinical Trials
Dengue Virus (DENV) is an arbovirus (arthropod-borne virus). Four serotypes of DENV are responsible for the infectious disease called dengue that annually affects nearly 400 million people worldwide.
Josilene Ramos Pinheiro-Michelsen +9 more
doaj +1 more source
Graphical Abstract and Lay Summary To further increase protein expression, it is imperative to improve cellular performance, a process intrinsically linked to cell metabolism. Hence, a metabolic footprint of Drosophila S2 cells, both recombinant‐ and wild‐types, was performed to enhance the production of the recombinant rabies virus glycoprotein ...
Monize Caiado Decarli +6 more
wiley +1 more source

