Results 51 to 60 of about 33,657 (222)
Development of MVA-d34 Tetravalent Dengue Vaccine: Design and Immunogenicity
Vaccines, 2023 Dengue fever, an infectious disease that affects more than 100 million people every year, is a global health problem. Vaccination may be the most effective prevention strategy for the disease.
Ramil R. Mintaev +6 more
doaj +1 more source
Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study. [PDF]
, 2010 BACKGROUND: The physiopathology of dengue hemorrhagic fever (DHF), a severe form of Dengue Fever, is poorly understood. We are unable to identify patients likely to progress to DHF for closer monitoring and early intervention during epidemics, so most ...
Maria Aparecida A. Figueiredo +27 more
core +1 more source
Towards understanding of the replication and pathogenesis of dengue infection [PDF]
, 2007 Dengue is the most important human viral disease transmitted by arthropod vectors and over half of the world's population live in areas at risk of infection. Currently there is neither specific treatment nor vaccine to tackle this emerging disease. The
Umareddy, Indira
core +1 more source
Cell, 2016 Denvaxia is the first licensed vaccine for the prevention of dengue. It is a live vaccine developed using recombinant DNA technology. The vaccine is given as three doses over the course of a year and has the potential to prevent hundreds of thousands of hospitalizations each year.
openaire +2 more sources
Cost Effectiveness and Resource Allocation, 2018 Background Malaysia has been experiencing an escalation in dengue cases since the past 5 years. As the dengue vaccine pipeline continues to develop steadily with strong public interests, this study had been sought to elicit the acceptance and the ...
Hui Yee Yeo, Asrul Akmal Shafie
doaj +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Current status of the development of dengue vaccines
Vaccine: XDengue fever is caused by the mosquito-borne dengue virus (DENV), which is endemic in more than 100 countries. Annually, there are approximately 390 million dengue cases, with a small subset manifesting into severe illnesses, such as dengue haemorrhagic ...
Michelle Felicia Lee +2 more
doaj +1 more source
Trends in clinical trials of dengue vaccine
Perspectives in Clinical Research, 2016 Dengue is one of the most important vector-borne disease and an increasing problem worldwide because of current globalization trends. Roughly, half the world′s population lives in dengue endemic countries, and nearly 100 million people are infected ...
Priya Marimuthu, Jamuna Rani Ravinder
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley +1 more source
British National Formulary Guidance on prescribing in pregnancy: A descriptive cross‐sectional study
British Journal of Clinical Pharmacology, EarlyView.Aim To assess how well pregnancy‐specific guidance within the British National Formulary supports healthcare professionals to facilitate safe and effective medication use. Methods We performed a manifest content analysis of the text of all pregnancy sections within British National Formulary drug monographs, with inductive and iterative coding.
Hannah Johnson +9 more
wiley +1 more source