Results 41 to 50 of about 55,779 (204)
Neutropenia as an adverse event following vaccination : results from randomized clinical trials in healthy adults and systematic review [PDF]
, 2016 Background : In the context of early vaccine trials aimed at evaluating the safety profile of novel vaccines, abnormal haematological values, such as neutropenia, are often reported.
Aerssens, Annelies +10 more
core +4 more sources
Cell, 2016 Denvaxia is the first licensed vaccine for the prevention of dengue. It is a live vaccine developed using recombinant DNA technology. The vaccine is given as three doses over the course of a year and has the potential to prevent hundreds of thousands of hospitalizations each year.
openaire +2 more sources
Comparison of Two Detailed Models of Aedes aegypti Population Dynamics [PDF]
, 2016 The success of control programs for mosquito-borne diseases can be enhanced by crucial information provided by models of the mosquito populations.
Arrivillaga J. +9 more
core +1 more source
Willingness to accept the Dengue vaccine among adult Malaysians – An online survey
Human Vaccines & ImmunotherapeuticsStudying the willingness to accept a new vaccine helps better understand the consumer behavior to formulate strategies to improve its acceptance when rolled out on a large scale.
Chandrashekhar T. Sreeramareddy +7 more
doaj +1 more source
Trends in clinical trials of dengue vaccine
Perspectives in Clinical Research, 2016 Dengue is one of the most important vector-borne disease and an increasing problem worldwide because of current globalization trends. Roughly, half the world′s population lives in dengue endemic countries, and nearly 100 million people are infected ...
Priya Marimuthu, Jamuna Rani Ravinder
doaj +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Current status of the development of dengue vaccines
Vaccine: XDengue fever is caused by the mosquito-borne dengue virus (DENV), which is endemic in more than 100 countries. Annually, there are approximately 390 million dengue cases, with a small subset manifesting into severe illnesses, such as dengue haemorrhagic ...
Michelle Felicia Lee +2 more
doaj +1 more source
Cost Effectiveness and Resource Allocation, 2018 Background Malaysia has been experiencing an escalation in dengue cases since the past 5 years. As the dengue vaccine pipeline continues to develop steadily with strong public interests, this study had been sought to elicit the acceptance and the ...
Hui Yee Yeo, Asrul Akmal Shafie
doaj +1 more source
Zika virus infection in the returning traveller: what every neurologist should know [PDF]
, 2018 Zika virus has been associated with a wide range of neurological complications. Neurologists in areas without current active transmission of the virus may be confronted with Zika-associated neurological disease, as a large number of returning travellers ...
Brito Ferreira, Maria Lucia +6 more
core +6 more sources
Maltase 1 regulates DENV2 infection and life history in Aedes aegypti
Insect Science, EarlyView.Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li +5 more
wiley +1 more source