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Dengue is an arthropod-borne infection caused by a flavivirus and spread by the Aedes mosquitoes. Many of the countries where dengue is endemic are popular tourist destinations and the disease is an increasingly important problem encountered by international travelers.
Annelies, Wilder-Smith +1 more
openaire +2 more sources
Dengue is globally the most important arboviral infection of humans with an estimated 100 million infections per annum and 2.5 billion people at risk in >100 countries. The burden of dengue is substantial in economic terms and in the strain it places on already fragile health systems.
Jamie Whitehorn, Cameron P Simmons
openaire +1 more source
Background Dengue is the most rapidly spreading viral vector-borne disease in the world. Promising new dengue vaccines have contributed to a growing consensus that effective dengue control will require integrated strategies of vaccination and vector ...
Valerie K. Scott +3 more
doaj +1 more source
Dengue virus activates polyreactive, natural IgG B cells after primary and secondary infection. [PDF]
BACKGROUND: Dengue virus is transmitted by mosquitoes and has four serotypes. Cross-protection to other serotypes lasting for a few months is observed following infection with one serotype.
Low, Jenny G. +62 more
core +1 more source
Estimates of dengue force of infection in children in Colombo, Sri Lanka. [PDF]
Dengue is the most important vector-borne viral disease worldwide and a major cause of childhood fever burden in Sri Lanka, which has experienced a number of large epidemics in the past decade.
Harold S Margolis +26 more
core +1 more source
Bioethics of establishing a CHIM model for dengue vaccine development
Introduction: Controlled human infection models (CHIM) have been used in vaccine development to up-select and down-select potential vaccine candidates and to provide proof of vaccine efficacy, and have also been used as a basis for licensure of vaccines ...
Anuradha Rose, Amrita Sekhar
doaj +1 more source
With one vaccine on the market and others in clinical trials, policy makers in dengue endemic regions face the decision of whether to introduce a dengue vaccine in their communities.
Elizabeth McMahon +14 more
doaj +1 more source
Dengue vaccine development: Global and Indian scenarios
India is home to nearly a third of the global population at risk of dengue, a viral disease caused by four antigenically and genetically distinct dengue viruses.
Sathyamangalam Swaminathan, Navin Khanna
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Vaccines licensed and in clinical trials for the prevention of dengue
Dengue has become a major global public health threat with almost half of the world's population living in at-risk areas. Vaccination would likely represent an effective strategy for the management of dengue disease in endemic regions, however to date ...
J. Torresi, G. Ebert, M. Pellegrini
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Challenges in Dengue Vaccines Development: Pre-existing Infections and Cross-Reactivity
Dengue is one of the most frequently transmitted mosquito-borne diseases in the world, which creates a significant public health concern globally, especially in tropical and subtropical countries.
Abdullah M. Izmirly +10 more
doaj +1 more source

