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Challenges in Dengue Vaccines Development: Pre-existing Infections and Cross-Reactivity

Frontiers in Immunology, 2020
Dengue is one of the most frequently transmitted mosquito-borne diseases in the world, which creates a significant public health concern globally, especially in tropical and subtropical countries.
Abdullah M. Izmirly, Abdullah M. Izmirly, Abdullah M. Izmirly, Sana O. Alturki, Sana O. Alturki, Sawsan O. Alturki, Sawsan O. Alturki, Jennifer Connors, Jennifer Connors, Elias K. Haddad, Elias K. Haddad   +10 more
doaj   +1 more source

Towards understanding of the replication and pathogenesis of dengue infection [PDF]

, 2007
Dengue is the most important human viral disease transmitted by arthropod vectors and over half of the world's population live in areas at risk of infection. Currently there is neither specific treatment nor vaccine to tackle this emerging disease. The
Umareddy, Indira
core   +1 more source

Assessing the potential of a candidate dengue vaccine with mathematical modeling [PDF]

, 2012
Dengue viruses are single-stranded positive-sense RNA viruses (genus Flavivirus, family Flaviviridae) that are the etiological agents of dengue fever (DF).
WHO-VMI Dengue Vaccine Modeling Group, Gomes, M. Gabriela M.   +1 more
core   +2 more sources

Immunogenicity, Safety and Efficacy of the Dengue Vaccine TAK-003: A Meta-Analysis [PDF]

Vaccines
Annalisa Rosso, Lamberto Manzoli, Maria Elena Flacco   +2 more
exaly   +2 more sources

Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study. [PDF]

, 2010
BACKGROUND: The physiopathology of dengue hemorrhagic fever (DHF), a severe form of Dengue Fever, is poorly understood. We are unable to identify patients likely to progress to DHF for closer monitoring and early intervention during epidemics, so most ...
Maria Aparecida A. Figueiredo, Lima, José Wellington O, Costa, Maria CN, Teixeira, Maria Glória, Maria C. N. Costa, Maria Glória Teixeira, Laura C. Rodrigues, Morato, Vanessa, Maria C N Costa, Pedro F. C. Vasconcelos, Maria Aparecida A. Figueiredo, Barreto, Maurício L, Figueiredo, Maria Aparecida A, Maurício L Barreto, Ronald Blanton, Pedro F C Vasconcelos, Márcio R. T. Nunes, Maria Aparecida A Figueiredo, Maurício L. Barreto, Blanton, Ronald, Vanessa Morato, José Wellington O Lima, Laura C Rodrigues, Márcio R T Nunes, Vasconcelos, Pedro FC, Rodrigues, Laura C, José Wellington O. Lima, Nunes, Márcio RT   +27 more
core   +2 more sources

A Dengue Vaccine

Cell, 2016
Denvaxia is the first licensed vaccine for the prevention of dengue. It is a live vaccine developed using recombinant DNA technology. The vaccine is given as three doses over the course of a year and has the potential to prevent hundreds of thousands of hospitalizations each year.
openaire   +2 more sources

Trends in clinical trials of dengue vaccine

Perspectives in Clinical Research, 2016
Dengue is one of the most important vector-borne disease and an increasing problem worldwide because of current globalization trends. Roughly, half the world′s population lives in dengue endemic countries, and nearly 100 million people are infected ...
Priya Marimuthu, Jamuna Rani Ravinder
doaj   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Current status of the development of dengue vaccines

Vaccine: X
Dengue fever is caused by the mosquito-borne dengue virus (DENV), which is endemic in more than 100 countries. Annually, there are approximately 390 million dengue cases, with a small subset manifesting into severe illnesses, such as dengue haemorrhagic ...
Michelle Felicia Lee, Chiau Ming Long, Chit Laa Poh   +2 more
doaj   +1 more source

The acceptance and willingness to pay (WTP) for hypothetical dengue vaccine in Penang, Malaysia: a contingent valuation study

Cost Effectiveness and Resource Allocation, 2018
Background Malaysia has been experiencing an escalation in dengue cases since the past 5 years. As the dengue vaccine pipeline continues to develop steadily with strong public interests, this study had been sought to elicit the acceptance and the ...
Hui Yee Yeo, Asrul Akmal Shafie
doaj   +1 more source