Revealing the molecular signatures of host-pathogen interactions. [PDF]
, 2011 Advances in sequencing technology and genome-wide association studies are now revealing the complex interactions between hosts and pathogen through genomic variation signatures, which arise from evolutionary co ...
C Herdtweck +53 more
core +13 more sources
Immunogenicity of NS4b dengue 3 virus mimotope presented to the immune system as multiple antigen peptide system [PDF]
, 2013 The availability of random peptide libraries displayed on bacteriophage (RPL) has provided a powerful tool for selecting sequences that mimic binding properties of natural antigen epitopes (mimotopes). These mimotopes can be used for vaccine design, drug
Acosta, Armando +11 more
core +2 more sources
International Journal of Infectious Diseases, 2017 Background: Dengue is an important public health problem worldwide. A vaccine has recently been licensed in some countries of Latin America and Asia. Recommendations for dengue vaccine introduction include endemicity and a high serological prevalence of ...
Mabel Carabali +9 more
doaj +1 more source
Analysis of the optimal vaccination age for dengue in Brazil with a tetravalent dengue vaccine [PDF]
Mathematical Biosciences, 2017 In this paper we study a mathematical model to analyse the optimal vaccination age against Dengue in Brazil. Data from Brazil are used to estimate the basic reproduction numbers for each of the four Dengue serotypes and then the optimal vaccination age is calculated using a method due to Hethcote [1].
Maier, Sandra B. +5 more
openaire +4 more sources
Monoclonal antibody-based capture ELISA in the diagnosis of previous dengue infection
Virology Journal, 2019 Background Dengue is an important mosquito-borne disease. There is currently only one licensed vaccine for dengue prevention. The vaccine provides higher efficacy in pre-vaccination dengue-seropositive persons but a higher risk of subsequent more severe ...
Chukiat Sirivichayakul +7 more
doaj +1 more source
Specific detection of dengue and Zika virus antibodies using envelope proteins with mutations in the conserved fusion loop [PDF]
, 2017 Detection of antibodies is widely used for the diagnosis of infections with arthropod-borne flaviviruses including dengue (DENV) and Zika virus (ZIKV). Due to the emergence of ZIKV in areas endemic for DENV, massive co-circulation is observed and methods
Barzon, Luisa +12 more
core +2 more sources
A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis [PDF]
, 2017 The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium.
Diamond, Michael S +4 more
core +5 more sources
Live-attenuated tetravalent dengue vaccines: The needs and challenges of post-licensure evaluation of vaccine safety and effectiveness. [PDF]
, 2017 Since December 2015, the first dengue vaccine has been licensed in several Asian and Latin American countries for protection against disease from all four dengue virus serotypes.
Asturias, Edwin J +9 more
core +2 more sources
Microbiology Australia, 2011 Dengue is globally the most important arboviral infection of humans with an estimated 100 million infections per annum and 2.5 billion people at risk in >100 countries. The burden of dengue is substantial in economic terms and in the strain it places on already fragile health systems.
Jamie Whitehorn, Cameron P Simmons
openaire +1 more source
Dengvaxia: the world’s first vaccine for prevention of secondary dengue
Therapeutic Advances in Vaccines and Immunotherapy, 2021 The objective of this manuscript was to review and evaluate the efficacy and safety data of Dengvaxia for the treatment of severe secondary dengue infection. Dengvaxia is the brand name for chimeric yellow fever-dengue-tetravalent dengue vaccine (CYD-TDV)
Danielle Tully, Carrie L. Griffiths
doaj +1 more source