Results 51 to 60 of about 100,685 (253)

Structural proteomics of dengue virus [PDF]

Current Opinion in Microbiology, 2008
In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle based on new structural data of the virus and its proteins. Specifically, we focus on the structure of the pre-membrane protein, prM and its role in virus assembly, the first full-length structure of a multi-domain dengue virus replication protein, NS3, and the ...
Rushika, Perera, Richard J, Kuhn
openaire   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Hanta Virus Infection During Dengue Virus Infection Outbreak in Indonesia [PDF]

, 2009
Aim: to investigate which recent infection could have caused the present dengue-like symptoms, in adult patients clinically fulfilling the WHO criteria for dengue, in which serologically were not confirmed for dengue virus infections.
Hadisaputro, Suharyo, Djokomoeljanto, Robert J., Dolmans, Wil M.V., Groen, Jan, Osterhaus , Ab D.M.E, Suharti, Catharina, Meer, Jos W.M. van der, Gorp, Eric C.M. van   +7 more
core  

Dengue- und Chikungunya-Fieber in der Allgemeinpraxis [PDF]

, 2009
Quintessenz: Dengue und Chikungunya sind akute Viruserkrankungen mit hohem Fieber, Kopfschmerzen, Gliederschmerzen, Hautausschlägen, welche in zahlreichen Ländern des Südens sehr verbreitet sind und auch Touristen betreffen.
Blum, J., Hatz, C. F., Hatz, C, Blum, J
core   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Quasispecies of dengue virus

Tropical Medicine and Health, 2011
Pathogenic viruses have RNA genomes that cause acute and chronic infections. These viruses replicate with high mutation rates and exhibit significant genetic diversity, so-called viral quasispecies. Viral quasispecies play an important role in chronic infectious diseases, but little is known about their involvement in acute infectious diseases such as ...
openaire   +3 more sources

Biological control of dengue and Wolbachia-based strategies. 2nd ed.

, 2014
This book chapter describes a number of biological control methods that currently exist, or are under development, which target the dengue vector Aedes aegypti.
Vasudevan, S, Frentiu, Scott L., F. D. Frentiu, Frentiu, F, Walker, T, Farrar, J, T. Walker, Walker, Thomas, O'Neil, Scott L., S. L. O'Neill, O'Neill, Scott L., Ooi, E, O'Neill, S, Gubler, D, Frentiu, Francesca D.   +14 more
core   +1 more source

Prophylactic platelets in dengue: survey responses highlight lack of an evidence base. [PDF]

, 2012
Dengue is the most important arboviral infection of humans. Thrombocytopenia is frequently observed in the course of infection and haemorrhage may occur in severe disease.
Guzman Maria G., Maria G Guzman, Mattias Larsson, Simmons, C, Bausch, Daniel G, Mishra, A, Lum, Lucy, Rosmari Rodriguez Roche (155596), James Whitehorn, Joshua Dawurung (155638), Mattias Larsson (155704), Larsson Mattias, Peeling, Rosanna, Alvaro Borges, Wills Bridget, Guzman, MG, Horstick, O, Joshua Dawurung, Nainggolan Leonard, Eric Martinez (155603), Wills, Bridget, Axel Kroeger, Ida Safitri Laksono (155613), Borges, Alvaro Humberto Diniz, Maria G. Guzman (155599), Abul Faiz, Wilmar Villamil Gomez, Daniel G. Bausch (155663), Larsson, Mattias, Farrar, Jeremy, Leonard Nainggolan (155609), Wertheim, H, Whitehorn, James, Sall Amadou, Guzman, Maria G, Mishra, Ajay, Roche Rosmari Rodriguez, Hien, T, Daniel G Bausch, Rosanna Peeling (155709), Olaf Horstick (155685), Hien, TT, Axel Kroeger (155674), Maria G. Guzman, Cameron Simmons (74669), Blumberg Lucille, Horstick Olaf, Gomez, W, Dawurung, J, Gomez, Wilmar Villamil, Ajay Mishra (155618), Heiman Wertheim, Sall, A, Faiz, Abul, Nainggolan, L, Dawurung, Joshua, Wilmar Villamil Gomez (155606), Thwaites, G, Laksono, Ida Safitri, Heiman Wertheim (129740), Whitehorn, J, Lum Lucy, Simmons Cameron, Leo, YS, Larsson, M, Faiz Abul, Mishra Ajay, Nainggolan, Leonard, Lucille Blumberg, Horstick, Olaf, Leonard Nainggolan, Peeling Rosanna, Kroeger, Axel, Alvaro Borges (155644), Laksono Ida Safitri, Farrar Jeremy, Yee-Sin Leo, Abul Faiz (155627), Tran Tinh Hien, [No Value], Rodriguez Roche, Rosmari, Wertheim Heiman, Simmons, Cameron, Laksono, IS, Amadou Sall, Wills, B, Martinez, Eric, Rosanna Peeling, Hien Tran Tinh, Yee-Sin Leo (102044), Bausch Daniel G., Borges, Alvaro, Bausch, Daniel G., Lucy Lum, Bridget Wills (74672), Tran Tinh Hien, Guzman, Maria G., Whitehorn James, Martinez Eric, Lum, L, Bausch, DG, Eric Martinez, Farrar, J, Daniel G. Bausch, Kroeger, A, Jeremy Farrar, Thwaites Guy, Kroeger Axel, Hien, Tran, Borges Alvaro, Leo, Yee-Sin, Villamil Gomez Wilmar, Ajay Mishra, Hien, Tran Tinh, Jeremy Farrar (74677), Leo Yee-Sin, Tran Tinh Hien (74675), Martinez, E, Lucy Lum (155622), Rosmari Rodriguez Roche, Lucille Blumberg (155654), Guy Thwaites (155694), Thwaites, Guy, Blumberg, L, Olaf Horstick, Sall, Amadou, James Whitehorn (155594), Ida Safitri Laksono, Guy Thwaites, Rodriguez Roche, R, Cameron Simmons, Gomez, WV, Bridget Wills, Roche, RR, Borges, A, Amadou Sall (155633), Peeling, R, Roche, Romari Rodriguez, Blumberg, Lucille, Wertheim, Heiman, Faiz, A, Dawurung Joshua   +140 more
core   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Reverse genetics rescue of sylvatic dengue viruses

Journal of Virology
There are an unknown number of sylvatic (“sylvan” = “of the forest”) dengue viruses currently being sustained by nonhuman primates and mosquitoes in the forests of Africa and Asia.
Paul Gendler, Arturo Barbachano-Guerrero, Samuel D. Chappell, Oshani C. Ratnayake, Samantha M. Pinto, Rushika Perera, Sara L. Sawyer   +6 more
doaj   +1 more source