Results 91 to 100 of about 1,161,134 (263)

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Dengue virus type 3 infection in a traveler returning from Costa Rica to Japan in 2023

Tropical Medicine and Health
The number of dengue cases has increased dramatically in recent years. In Latin America, the number of cases and deaths in 2023 was the highest ever recorded. We report on a patient who had been infected with dengue virus during his stay in Costa Rica in
Tadahiro Sasaki, Ryo Morita, Ikuko Aoyama, Takashi Baba, Tetsushi Goto, Ritsuko Kubota-Koketsu, Yoshihiro Samune, Emi E. Nakayama, Tatsuo Shioda, Michinori Shirano   +9 more
doaj   +1 more source

Evaluation of the performance of a dengue outbreak detection tool for China [PDF]

, 2014
An outbreak detection and response system, using time series moving percentile method based on historical data, in China has been used for identifying dengue fever outbreaks since 2008.
Wang, Liping, Yang, Weizhong, Clements, Archie C.A., Shengjie Lai, Hu, Wenbiao, Wenwu Yin, Yin, Wenwu, Hang Zhou, Zhou, Hang, Archie C A Clements, Archie C. A. Clements, Li, Zhongjie, Yu, Hongjie, Zhongjie Li, Lai, Shengjie, Weizhong Yang, Wenbiao Hu, Zhang, Honglong, Hongjie Yu, Clements, Archie C. A., Liping Wang, Honglong Zhang   +21 more
core   +1 more source

Early tocilizumab and outcomes in acute necrotizing encephalopathy

Developmental Medicine &Child Neurology, EarlyView.
Early tocilizumab and outcome in acute necrotising encephalopathy. Aim To evaluate the timing and safety of tocilizumab in acute necrotizing encephalopathy (ANE). Method This was a multicentre retrospective study evaluating outcomes (modified Rankin Scale [mRS]) in children with ANE treated with tocilizumab. A logistic regression model determined a cut‐
Velda X Han, Prithuja Poudyal, Vanessa Lee, Arushi Gahlot Saini, Shekeeb S Mohammad, Sekhar C Pillai, Gouri Rao Passi, Naveen Sankhyan, Ahmad Rithauddin Mohamed, Lokesh Lingappa, Hiroshi Sakuma, Russell C Dale, Ming Lim, Terrence Thomas, for The International ANE Study Group   +14 more
wiley   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

The early clinical features of dengue in adults: challenges for early clinical diagnosis. [PDF]

, 2011
BACKGROUND: The emergence of dengue throughout the tropical world is affecting an increasing proportion of adult cases. The clinical features of dengue in different age groups have not been well examined, especially in the context of early clinical ...
Chaterji, S., Lee-Ching Ng, Martin L. Hibberd, Chow, Angelia, Sharon W. S. Tan, Chua, C.R., Vasudevan Subhash G., Martin L Hibberd, Ooi Eng Eong, Leo Yee Sin, Choon Rong Chua, Chua Robert, Vasudevan, Subhash G, Chaterji, Shera, Leo, Yee Sin, Cheung, Yin Bun, Ng, Lee-Ching, Leo, Y.S., Chow, A., Ong Adrian, Cheung Yin Bun, Lim Wen Yan, Yin Bun Cheung, Chua Choon Rong, Adrian Ong, Yee Sin Leo, Low, Jenny GH, Hibberd, M.L., Subhash G Vasudevan, Low Jenny G. H., Ong, A., Cheung, Y.B., Ooi, E.E., Ng, L.-C., Low, J.G.H., Vasudevan, S.G., Jenny G. H. Low, Hibberd Martin L., Wen Yan Lim, Eng Eong Ooi, Tan Li Kiang, Lee, K.W., Jenny G H Low, Ong, Adrian, Lim, W.Y., Shera Chaterji, Chua, R., Koon Wui Lee, Tan Sharon W. S., Lim, Wen Yan, Ng Lee-Ching, Subhash G. Vasudevan, Lee Koon Wui, Robert Chua, Chaterji Shera, Ooi, Eng Eong, Hibberd, Martin L, Tan, L.K., Tan, S.W.S., Angelia Chow, Li Kiang Tan, Lee, Koon Wui, Tan, Sharon WS, Tan, Li Kiang, Sharon W S Tan, Chua, Choon Rong, Chua, Robert, Chow Angelia   +67 more
core   +2 more sources

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

The FEBS Journal, EarlyView.
C‐type lectins (CTLs) are involved in the detection of viral/microbial carbohydrates. We studied a family of soluble CTLs in the mosquito Aedes aegypti, which acts as a vector for viruses like dengue and Zika. Using crystallography, biophysics, and structure prediction approaches, we found that these proteins consistently pair together in the same ...
Mattia Bertinelli, Rupesh Balaji Jayachandran, Jack Whitehead, Cédric Leyrat, Annabel v. Clanner, Guido C Paesen, Max Renner   +6 more
wiley   +1 more source

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

STUDIES ON DENGUE VIRUS (XI)

VIRUS, 1957
Electron micrographs of dengue viruses of Hawaiian strain and Mochizuki strain, which were adapted to mouse brain and chick embryo have been taken using purified virus materials.Purification methods employed were as follows: (I) Combination of partial purification of the virus adsorption to and elution from erythrocytes and ultracentrifuge, (2 ...
YOH NAKAGAWA, MASAHISA SHINGU
openaire   +3 more sources

Preimaginal development of Aedes aegypti L. (Diptera: Culicidae) in brackish water gives rise to adult mosquitoes with thicker cuticles and greater insecticide resistance

Medical and Veterinary Entomology, EarlyView.
The principal arboviral vector Aedes aegypti can develop in coastal brackish water field habitats (0.5–15 g/L salt) with larvae possessing thicker cuticles and greater resistance to the larvicide Temephos. Females emerging from brackish water‐developing preimaginal stages are now shown to have thicker and remodelled leg and abdominal cuticles and ...
Kokila Sivabalakrishnan, Andrew Hemphill, S. H. P. Parakrama Karunaratne, Arunasalam Naguleswaran, Isabel Roditi, Sinnathamby N. Surendran, Ranjan Ramasamy   +6 more
wiley   +1 more source