Results 61 to 70 of about 1,161,134 (263)

N‐acetylcysteine for non‐paracetamol‐induced acute liver failure in children: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Non‐surgical treatment of acute liver failure (ALF) is primarily supportive and depends on the underlying cause. While N‐acetylcysteine (NAC) is proven effective in paracetamol‐induced ALF, its potential benefits in non‐paracetamol ALF for paediatric patients remain unclear.
Alise D. E. de Groot, Désanka M. Stoppels, Arno R. Bourgonje, Willemien F. J. Hof, Martin C. J. Kneyber, Daan J. Touw, Henkjan J. Verkade, Paola Mian   +7 more
wiley   +1 more source

Reverse genetics rescue of sylvatic dengue viruses

Journal of Virology
There are an unknown number of sylvatic (“sylvan” = “of the forest”) dengue viruses currently being sustained by nonhuman primates and mosquitoes in the forests of Africa and Asia.
Paul Gendler, Arturo Barbachano-Guerrero, Samuel D. Chappell, Oshani C. Ratnayake, Samantha M. Pinto, Rushika Perera, Sara L. Sawyer   +6 more
doaj   +1 more source

Seroprevalence of Dengue and Chikungunya Virus Antibodies, French Polynesia, 2014–2015

Emerging Infectious Diseases, 2018
We investigated dengue and chikungunya virus antibody seroprevalence in French Polynesia during 2014–2015. Dengue virus seroprevalence was ≈60% among schoolchildren and >83% among the general population; chikungunya virus seroprevalence was
Maite Aubry, Anita Teissier, Michael Huart, Sébastien Merceron, Jessica Vanhomwegen, Mihiau Mapotoeke, Teheipuaura Mariteragi-Helle, Claudine Roche, Anne-Laure Vial, Sylvianne Teururai, Sébastien Sicard, Sylvie Paulous, Philippe Desprès, Jean-Claude Manuguerra, Henri-Pierre Mallet, Allison Imrie, Didier Musso, Xavier Deparis, Van-Mai Cao-Lormeau   +18 more
doaj   +1 more source

Association of Dengue Virus Serotypes 1&2 with Severe Dengue Having Deletions in Their 3′Untranslated Regions (3′UTRs)

Microorganisms, 2023
Dengue virus infections are recorded as hyper-endemic in many countries, including India. Research pertaining to the reasons for frequent outbreaks and severe dengue is ongoing.
Deepti Maisnam, Arcy Billoria, V. S. V Prasad, Musturi Venkataramana   +3 more
doaj   +1 more source

Models of dengue virus infection [PDF]

Drug Discovery Today: Disease Models, 2006
The need for models of dengue disease has reached a pinnacle as the transmission of this mosquito-borne virus has increased dramatically. Little is known about the mechanisms that lead to dengue fever and its more severe form, dengue hemorrhagic fever; this is owing to the fact that only humans show signs of disease.
Dennis A, Bente, Rebeca, Rico-Hesse
openaire   +2 more sources

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism [PDF]

, 2005
Background: Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is associated with increased PAI-1 ...
ten Cate, H, Brandjes, DPM, Hack, C. Erik, Mairuhu, ATA, Leyte, A, Osterhaus, ADME, Faradz, Sultana M.H., Reitsma, PH, Setiati, Tatty E., van Gorp, Eric C. M., Koraka, P   +10 more
core   +4 more sources

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Dengue and Dengue Virus in Florida

EDIS
This publication provides an overview of dengue fever, focusing on its epidemiological landscape in Florida. Dengue, caused by dengue virus and transmitted through the bites of infected Aedes mosquitoes, is a major global health concern. Florida has experienced local dengue transmissions, and the incidence of dengue is increasing in the state.
Yasmin V. Ortiz, Daniel W. Pérez-Ramos, Eric P. Caragata, Panpim Thongsripong   +3 more
openaire   +1 more source

Development and External Validation of Logistic Regression Models Integrating Conventional Complete Blood Count and Cell Population Data for Predicting RT‐PCR–Confirmed Dengue

Journal of Clinical Laboratory Analysis, EarlyView.
We developed logistic regression models integrating routine complete blood count (CBC) parameters and analyzer‐derived cell population data (CPD) to predict RT‐PCR–confirmed dengue infection and evaluated their performance across internal and external settings.
Lin‐Chen Hsu, Yu‐Ching Weng, Wen‐Chun Liu   +2 more
wiley   +1 more source