Results 131 to 140 of about 588,860 (289)

First Characterization of the Neospora caninum Dense Granule Protein GRA9

, 2017
The obligate intracellular apicomplexan parasiteis closely related to. The dense granules, which are present in all apicomplexan parasites, are important secretory organelles. Dense granule (GRA) proteins are released into the parasitophorous vacuole (PV)
Däubener, Walter, Schares, Gereon, Spekker-Bosker, Katrin, Ince, Vanessa, Leineweber, Margret, Eller, Silvia K, Hemphill, Andrew   +6 more
core   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Thiazole orange: a complement to established methods for diagnosing inherited dense granule defects

Platelets
Inherited delta storage pool deficiencies are likely underdiagnosed due to limitations in available diagnostic tools. Achieving accurate diagnosis is thus challenging for clinical laboratories highlighting the need for improved methods.
Myriam Martin, Karin Strandberg, Eva Zetterberg, Eva Norström   +3 more
doaj   +1 more source

ON THE NATURE OF THE DENSE MATRIX GRANULES OF NORMAL MITOCHONDRIA [PDF]

The Journal of Cell Biology, 1969
I, Pasquali-Ronchetti, J W, Greenawalt, E, Carafoli   +2 more
openaire   +2 more sources

Vine‐Inspired Soft Robotics: Materials, Actuations, and Emerging Applications

Advanced Science, EarlyView.
Vine‐inspired robots grow from the tip, enabling navigation through confined spaces with minimal disturbance. This Review summarizes material and actuation strategies for vine‐inspired growth, key functions including steering, retraction, attachment, branching, and variable stiffness, and emerging applications spanning medical intervention, confined ...
Jiahao Wu, Xingyun Liu, Fangzhou Wang, Huili Ren, Chaojun Zhang, Ziyu Ren, Zunqi Liu, Jing Li   +7 more
wiley   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

Advanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng, Selina Luhmann, Aditi Saha, Marta Orlando, Haider Sami, Timo Glatter, Anna Antoniou   +6 more
wiley   +1 more source

A zinc transporter, transmembrane protein 163, is critical for the biogenesis of platelet dense granules.

Blood, 2021
Yuan Y, Liu T, Huang X, Chen Y, Zhang W, Li T, Yang L, Chen Q, Wang Y, Wei A, Li W.   +10 more
europepmc   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Expression of cellular prion protein on platelets from patients with gray platelet or Hermansky-Pudlak syndrome and the protein's association with alpha-granules

Haematologica, 2006
The cellular prion protein (PrPc) is a membrane glycoprotein expressed on many human cells including platelets. We investigated the cellular localization of platelet PrPc. In resting platelets most PrPc was localized inside the cells.
K Holada, H Glierova, J Simak, JG Vostal
doaj  

Heterogeneous Ultrastructure of Keratohyalin Granules: A Comparative Study of Adjacent Skin and Mucous Membrane

, 1973
Keratohyalin granules of the cheek epidermis, buccal epithelium, and transitional region of newborn rats were fixed by several different procedures and studied by electron microscopy.
Fukuyama, Kimie, Epstein, William L.
core   +1 more source