Results 111 to 120 of about 588,860 (289)

Fine ultrastructure of chromaffin granules in rat adrenal medulla indicative of a vesicle-mediated secretory process

open access: yes, 2006
Observation by transmission electron microscopy, coupled with morphometric analysis and estimation procedure, revealed unique ultrastructural features in 25.94% of noradrenaline (NA)- and 16.85% of adrenaline (A)-containing granules in the rat adrenal ...
GUIDOLIN, DIEGO   +4 more
core   +1 more source

AI‐Powered, Temperature‐Resolved Centrifugal Microfluidics for Rapid 3D Phase‐Diagram Generation of Biomolecular Condensates

open access: yesAdvanced Science, EarlyView.
By merging centrifugal microfluidics, precise temperature control, and AI image recognition, T‐PhaseMap transforms biomolecular condensate phase mapping into a rapid, temperature‐resolved workflow. It generates 3D composition–temperature phase diagrams within 30 min, resolves four phase states, and uncovers temperature‐dependent heparin sodium ...
Jiashuo Li   +6 more
wiley   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

open access: yesAdvanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao   +15 more
wiley   +1 more source

Technology for creating porous calcium phosphate granules

open access: yes
Calcium phosphates (CaP) are widely used as implant materials. Implant materials are prepared in various forms – blocks, scaffolds, coatings, powders and granules, either dense or porous.
Ločs, Jānis   +2 more
core  

Electron microscopy of large-cell NEC cell lines.

open access: yes, 2014
Electron microscopy revealed electron-dense large dense core neurosecretory granules in both NEC cell lines (inset demonstrates magnified electron dense granules). HCT116 served as negative control cell line.
Martin Anlauf (147770)   +13 more
core   +1 more source

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

open access: yesAdvanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer   +12 more
wiley   +1 more source

Platelet secretion in inflammatory and infectious diseases

open access: yesPlatelets, 2017
Platelets are small, anucleate circulating cells that possess a dynamic repertoire of functions spanning the hemostatic, inflammatory, and immune continuum. Once thought to be merely cell fragments with responses limited primarily to acute hemostasis and
Bhanu K. Manne   +2 more
doaj   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

open access: yesAdvanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang   +16 more
wiley   +1 more source

Structure and enzyme content of sea urchin cytolytic granules

open access: yes, 1993
Amoebocytes of the echinoderm (sea urchin), Paracentrotus lividus are responsible for cytotoxic activity. The cytotoxic event requires contact between effector and target cells and calcium-dependent hemolysins, causing disintegration and lysis of target ...
PAGLIARA, Patrizia   +1 more
core   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

open access: yesAdvanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo   +6 more
wiley   +1 more source

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