Results 101 to 110 of about 588,860 (289)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Ageing-induced changes in the cortical granules of mouse eggs [PDF]

, 2013
The cortical cytoplasm and cortical granules (CGs) of mouse oocytes were analysed by electron microscopy. Oocytes were collected soon and 20 h after ovulation from adult young females (3-4 months old).
Díaz, H., Esponda, Pedro
core   +1 more source

Experimental and morphological studies on atrial specific granules [PDF]

, 1978
Specific granules in the atrial muscle cells were examined in normal and treated rats with electron microscopy. By the Epon-embedded section, the specific granules existed in sarcoplasm along the nucleus and in sarcoplasm between myofibrils or beneath ...
Miwako TABATA, Tabata, Miwako
core   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Immune Protective Evaluation Elicited by DNA Vaccination With Neospora caninum Dense Granules Proteins in Mice. [PDF]

Front Vet Sci, 2021
Yu G, Liang W, Yang Q, Wang J, Wang Y, Zhang T, Zhang X, Fan H, Zhao P, Cao L, Dong J.   +10 more
europepmc   +1 more source

Platelet life without TMEM163: no dense granules [PDF]

Blood, 2021
Elmina, Mammadova-Bach, Attila, Braun
openaire   +2 more sources

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

The Ultrastructure of the Secretory Cells of the Human Carotid Body

Siriraj Medical Journal, 2007
Objective: The purpose of this study was to study the ultrastructure of the human carotid body by using transmission electron microscopy. This is to distinguish the secretory cells of the human carotid body and classify the cells by the characteristic ...
Kunnika Chatyingmongkol, Jantima Roongruangchai, Kajee Pilakasiri, Kasem Koedpuech   +3 more
doaj  

Electron-dense granules in Desulfovibrio gigas do not consist of inorganic triphosphate but of a glucose pentakis (diphosphate)

, 1996
Under certain growth conditions the sulfate-reducing bacterium Desulfovibrio gigas forms electron-dense granules in the cells which had been claimed to consist of a magnesium triphosphate).
Hensgens, C.M H, Kruizinga, WH, Zhang, C, Hansen, TA, Kruizinga, W.H, Hensgens, CMH, Santos, H, Hansen, T.A., Zhang, CH   +8 more
core   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source