Results 121 to 130 of about 588,860 (289)

Neurosurgical bleeding in platelet storage pool disorder: a case report

Platelets
Dense-granule deficiency (DGD) is an inherited platelet disorder due to the absence of dense granules essential for activation of platelets in the event of vascular injury.
Clifford Pierre, Kirsten W. Alcorn, Dong Chen, Joanna Fesler, Daniel Landis, Zachary N. Litvack, Barbara A. Konkle, Livia Hegerova   +7 more
doaj   +1 more source

Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes

MATEC Web of Conferences, 2013
Calcium phosphate ceramics like hydroxyapatite (HA) are widely used to repair and reconstruct damaged parts of the human skeleton. This material is currently available as injectable cements, granules or macroporous blocks. The most familiar materials are
Hornez J.C., Bouchart F., Meurice E., Descamps M., Leriche A.   +4 more
doaj   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Serotonin accumulation in granules of storage pool-deficient platelets of Chediak-Higashi cattle

, 1983
Platelets from cattle with the Chediak-Higashi (CH) syndrome are virtually devoid of dense granules, serotonin (5-HT), and stored ATP and ADP. The present study determined how the handling of 5-HT in normal cattle platelets differed from that in CH ...
H. Holmsen, K. M. Meyers, C. L. Seachord, K. Benson, M. Fukami   +4 more
core   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Platelet dense granule defect: experience in the French population

Research and Practice in Thrombosis and Haemostasis
Platelet dense granule defect (DGD) is a frequent inherited disorder that is underdiagnosed due to its complexity and poor standardization of diagnostic tools.To assess the prevalence of DGD in a large real-life French cohort of patients with an abnormal bleeding score.Patients with abnormal International Society on Thrombosis and Haemostasis Bleeding ...
Borgel, Delphine, Beauvais, Agathe, Bally, Cécile, Ibrahim‐kosta, Manal, Dupont, Annabelle, Paris, Camille, Vayne, Caroline, Voisin, Sophie, Goin, Valérie, Nam-Nguyen, Guillaume, Favier, Rémi, Dupuis, Arnaud, Eymieux, Sébastien, Bordet, Jean-Claude, Blanchard, Emmanuelle, Auditeau, Claire, Lasne, Dominique, Harroche, Annie, Alessi, Marie-Christine, Fiore, Mathieu   +19 more
openaire   +3 more sources

Independent Transport and Sorting of Functionally Distinct Protein Families in Tetrahymena thermophila Dense Core Secretory Granules

, 2009
Dense core granules (DCGs) in Tetrahymena thermophila contain two protein classes. Proteins in the first class, called granule lattice (Grl), coassemble to form a crystalline lattice within the granule lumen.
Turkewitz, AP, Univ Chicago, Dept Mol Genet & Cell Biol, 920 E 58th St, Chicago, IL 60637 USA, Turkewitz, Aaron P., Rahaman, Abdur, Miao, Wei   +3 more
core   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source