Results 91 to 100 of about 181,532 (295)

The impact of the Hall effect on high energy density plasma jets

open access: yes, 2013
Using a 1-MA, 100ns-rise-time pulsed power generator, radial foil configurations can produce strongly collimated plasma jets. The resulting jets have electron densities on the order of 10^20 cm^-3, temperatures above 50 eV and plasma velocities on the ...
Gourdain, P. -A., Seyler, C. E.
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Fields of a Bessel-Bessel light bullet of arbitrary order in an under-dense plasma

open access: yesScientific Reports, 2018
Considerable theoretical and experimental work has lately been focused on waves localized in time and space. In optics, waves of that nature are often referred to as light bullets.
Yousef I. Salamin
doaj   +1 more source

Theory of Fast Electron Transport for Fast Ignition

open access: yes, 2013
Fast Ignition Inertial Confinement Fusion is a variant of inertial fusion in which DT fuel is first compressed to high density and then ignited by a relativistic electron beam generated by a fast (< 20 ps) ultra-intense laser pulse, which is usually ...
Davies, J. R.   +8 more
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Unlocking the potential of microgreens: non-thermal innovations to enhance phytochemical and nutritional benefits

open access: yesFood Chemistry: X
Microgreens have recently gained importance being a dense source of bioactive compounds that offer several health benefits. This review explores the innovation in non-thermal techniques and their application in seed germination and microgreen cultivation,
Mansi Rawat   +3 more
doaj   +1 more source

PATHOPHISIOLOGY OF SICKLE CELL DISEASE AND NEW DRUGS FOR THE TREATMENT

open access: yesMediterranean Journal of Hematology and Infectious Diseases, 2009
A homozygous mutation in the gene for b globin, a subunit of adult hemoglobin A (HbA), is the proximate cause of sickle cell disease (SCD). Sickle hemoglobin (HbS) shows peculiar biochemical properties, which lead to polymerizing when deoxygenated.
Lucia De Franceschi
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Evaluation of a New Kind of Z-Pinch-Based Space Propulsion Engine: Theoretical Foundations and Design of a Proof-of-Concept Experiment

open access: yesPlasma
This paper explores a recently proposed scalable z-pinch-based space propulsion engine in greater detail. This concept involves a “modified plasma focus with a tapered anode that transports current from a pulsed power source to a consumable portion of ...
S. K. H. Auluck, R. Verma, R. S. Rawat
doaj   +1 more source

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