Results 71 to 80 of about 182,466 (287)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Magnetic field amplification and electron acceleration to near-energy equipartition with ions by a mildly relativistic quasi-parallel plasma protoshock

, 2010
The prompt emissions of gamma-ray bursts are seeded by radiating ultrarelativistic electrons. Internal shocks propagating through a jet launched by a stellar implosion, are expected to amplify the magnetic field & accelerate electrons.
A. Bret, Alexandrova, Amano, Amato, Bessho, Brainerd, Bret, Bret, Cary, Coburn, Cowan, Dawson, Dieckmann, Dieckmann, Dieckmann, Dupree, Fleishman, Forslund, Fox, Frederiksen, G. C. Murphy, Granot, Hammer, Hededal, Hjorth, Hoshino, Jaroschek, Kazimura, Kirk, Kirk, Kulkarni, L. O’ C. Drury, Lee, Lembège, Lembège, Lemoine, Leroy, Lyutikov, M. E. Dieckmann, Martins, Medvedev, Meszaros, Mora, Murphy, Murphy, Nishikawa, Nishikawa, Piran, Quest, Rees, Roth, Ryde, Schlickeiser, Schlickeiser, Scholer, Shikii, Silva, Sironi, Sorasio, Spitkovsky, Steele, Umeda, Waxman   +62 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Fast ignition of inertial fusion targets by laser-driven carbon beams

, 2009
Two-dimensional simulations of ion beam driven fast ignition are presented. Ignition energies of protons with Maxwellian spectrum and carbon ions with quasimonoenergetic and Maxwellian energy distributions are evaluated.
B. M. Hegelich, Honrubia J. J., J. C. Fernández, J. J. Honrubia, J. Meyer-ter-Vehn, M. Temporal   +5 more
core   +1 more source

Magnetically Induced Plasma Rotation and the Dense Plasma Focus

Zeitschrift für Naturforschung A, 1983
Abstract Fusion for Fission fuel breeding and other incentives for unconventional magnetic fusion research are introductorily mentioned. The design, operation and peculiar characteristics of dense plasma foci are briefly described with attention to their remarkable ion acceleration and plasma heating capabilities.
openaire   +1 more source

Fully three-dimensional simulation and modeling of a dense plasma focus [PDF]

The Journal of Defense Modeling and Simulation: Applications, Methodology, Technology, 2014
A dense plasma focus (DPF) is a pulsed-power machine that electromagnetically accelerates and cylindrically compresses a shocked plasma in a Z-pinch. The pinch results in a brief (~ 100 ns) pulse of X-rays, and, for some working gases, also a pulse of neutrons.
Meehan, B. T., Niederhaus, J. H. J.
openaire   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Molecular Metabolism, 2020
Background: Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD patients.
Audrey Deprince, Joel T. Haas, Bart Staels   +2 more
doaj   +1 more source

Linear and nonlinear ion-acoustic waves in non-relativistic quantum plasmas with arbitrary degeneracy

, 2015
Linear and nonlinear ion-acoustic waves are studied in a fluid model for non-relativistic, unmagnetized quantum plasma with electrons with an arbitrary degeneracy degree.
Haas, Fernando, Mahmood, Shahzad
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source