Results 61 to 70 of about 6,206,014 (287)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

ALEGRA-HEDP simulations of the dense plasma focus. [PDF]

, 2009
We have carried out 2D simulations of three dense plasma focus (DPF) devices using the ALEGRA-HEDP code and validated the results against experiments. The three devices included two Mather-type machines described by Bernard et. al. and the Tallboy device currently in operation at NSTec in North Las Vegas.
Flicker, Dawn G., Kueny, Christopher S. (Hewlett-Packard Company), Rose, David V.   +3 more
openaire   +2 more sources

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Molecular Metabolism, 2020
Background: Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD patients.
Audrey Deprince, Joel T. Haas, Bart Staels   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Quantitative Determination of Cellular-and Neurite Motility Speed in Dense Cell Cultures

Frontiers in Neuroinformatics, 2019
Mobility quantification of single cells and cellular processes in dense cultures is a challenge, because single cell tracking is impossible. We developed a software for cell structure segmentation and implemented 2 algorithms to measure motility speed ...
Andreas W. Henkel, Lulwa A. A. D. Al-Abdullah, Mohammed S. Al-Qallaf, Zoran B. Redzic   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Study of The Dynamical Behavior For Deuterons in Dense Plasma Focus

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
    The motion of fast deuterons in most dense plasma focus devices  ( DPF ) , may be characterized that it has a complex nature in its paths and this phenomena by describing a through gyrating motion with arbitrary changes in magnitude and direction . 
D. H. Yonas, R.H. Majeed
doaj  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Plasma patches inside the polar cap and auroral oval: the impact on the spaceborne GPS receiver

Journal of Space Weather and Space Climate, 2019
In this study, we focus on plasma patches with very dense plasma in the southern hemisphere during the main phase of 2015 St. Patrick’s Day storm. With in situ electron densities exceeding 1.5 × 1012 m−3 at 450–500 km altitude, the patches cause strong ...
Xiong Chao, Yin Fan, Luo Xiaomin, Jin Yaqi, Wan Xin   +4 more
doaj   +1 more source