Results 61 to 70 of about 50,398 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Temporal distribution of linear densities of the plasma column in a plasma focus discharge

Nukleonika, 2015
Experiments were carried out on the PF-1000 plasma focus device, with a deuterium filling and with deuterium puffing from a gas-puff nozzle placed on the axis of the anode face. The current was reaching 2 MA.
Cikhardtova Balzhima, Kubeš Pavel, Cikhardt Jakub, Paduch Marian, Zielinska Ewa, Kravárik Josef, Řezáč Karel, Kortanek Jiři, Šíla Ondřej   +8 more
doaj   +1 more source

Time Processing of Signals of NE102 and Stilbene Plastic Scintillator Detectors in Detecting Emission of Beams from Plasma Focus Device [PDF]

فیزیک کاربردی ایران
The plasma focus device is a pulsed source of soft X-ray (SXR), hard X-ray (HXR), ion beam, electron beam, and neutrons. In order to detect SXR, HXR, and neutrons, plastic scintillator detectors with different crystals are used.
Amir Raeisdana
doaj   +1 more source

Application of dense plasma focus devices and lasers in the radiation material sciences for the goals of inertial fusion beyond ignition

Matter and Radiation at Extremes, 2020
Specimens of materials for prospective use in chambers of nuclear fusion reactors with inertial plasma confinement, namely, W, ODS steels, Eurofer 97 steel, a number of ceramics, etc., have been irradiated by dense plasma focus ...
V. A. Gribkov, I. V. Borovitskaya, E. V. Demina, E. E. Kazilin, S. V. Latyshev, S. A. Maslyaev, V. N. Pimenov, T. Laas, M. Paduch, S. V. Rogozhkin   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Metal-insulator-metal capacitors based on lanthanum oxide high-κ dielectric nanolayers fabricated using dense plasma focus device

, 2014
Metal-insulator-metal (MIM) capacitors with lanthanum oxide (La2O3) high-κ dielectric, for potential applications in mixed-signal integrated circuit (IC), have been fabricated using a dense plasma focus device.
Ostrikov, Kostya, Onkar Mangla, Mangla, Onkar, Malhotra, Yashi, Kostya (Ken) Ostrikov, Srivastava, Asutosh, Yashi Malhotra, Asutosh Srivastava   +7 more
core   +1 more source

Hard X-Ray Emission Detection Using Deep Learning Analysis of the Radiated UHF Electromagnetic Signal From a Plasma Focus Discharge

IEEE Access, 2019
A method to determine the presence of hard X-ray emission processes from a dense plasma focus (205 J, 22 kV, 6.5 mbar H2) using Ultra High Frequency (UHF) measurements and deep learning techniques is presented.
Gonzalo Avaria, Jorge Ardila-Rey, Sergio Davis, Luis Orellana, Benjamin Cevallos, Cristian Pavez, Leopoldo Soto   +6 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Development of a Miniaturized 2-Joule Pulsed Plasma Source Based on Plasma Focus Technology: Applications in Extreme Condition Materials and Nanosatellite Orientation

Micromachines
Plasma focus devices represent a class of hot and dense plasma sources that serve a dual role in fundamental plasma research and practical applications.
Leopoldo Soto, Cristian Pavez, José Pedreros, Jalaj Jain, José Moreno, Patricio San Martín, Fermín Castillo, Daniel Zanelli, Luis Altamirano   +8 more
doaj   +1 more source