Results 81 to 90 of about 181,532 (295)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

X-ray emission from high temperature plasmas [PDF]

The physical processes occurring in plasma focus devices were studied. These devices produce dense high temperature plasmas, which emit X rays of hundreds of KeV energy and one to ten billion neutrons per pulse.
Harries, W. L.
core   +2 more sources

Irradiation of Materials with Short, Intense Ion pulses at NDCX-II

, 2017
We present an overview of the performance of the Neutralized Drift Compression Experiment-II (NDCX-II) accelerator at Berkeley Lab, and report on recent target experiments on beam driven melting and transmission ion energy loss measurements with ...
Barnard, JJ, Feinberg, E, Friedman, A, Gilson, EP, Grote, DP, Ji, Q, Kaganovich, ID, Ludewigt, B, Persaud, A, Schenkel, T, Seidl, PA, Sierra, C, Silverman, M, Stepanov, AD, Sulyman, A, Treffert, F, Waldron, WL, Zimmer, M   +17 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Unresolved fine-scale structure in solar coronal loop-tops

, 2014
New and advanced space-based observing facilities continue to lower the resolution limit and detect solar coronal loops in greater detail. We continue to discover even finer sub-structures within coronal loop cross sections, in order to understand the ...
Antolin, Patrick, Scullion, Eamon, van der Voort, Luc Rouppe, Wedemeyer, Sven   +3 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Instanton-induced crossover in dense QCD

, 2008
We study the properties of an instanton ensemble in three-flavor dense QCD which can be regarded as an instanton plasma weakly interacting by exchanging the eta' mesons.
G. Baym, J.M. Kosterlitz, M.G. Alford, Naoki Yamamoto, V.L. Berezinskii   +4 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Nonintegrable Interaction of Ion-Acoustic and Electromagnetic Waves in a Plasma

, 1996
In this paper we re-examine the one-dimensional interaction of electromagnetic and ion acoustic waves in a plasma. Our model is similar to one solved by Rao et al. (Phys. Fluids, vol. 26, 2488 (1983)) under a number of analytical approximations.
A. C.-L. Chian, A.C.-L. Chian, A.C.-L. Chian, A.J. Lichtenberg, E. Infeld, F. B. Rizzato, G. Corso, G. Corso, G.I. de Oliveira, G.I. de Oliveira, G.I. de Oliveira, H.T. Moon, J. Guckenheimer, J. Weiland, J.M. Wersinger, N.N. Rao, P.K. Kaw, R.J. Noble, S. R. Lopes, S.R. Lopes, W.L. Kruer, X.T. He   +21 more
core   +3 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source