Results 101 to 110 of about 149,082 (291)

Androgen receptor‐mediated regulation of BRCA1 modulates the antioxidant defense in prostate cancer

open access: yesThe Journal of Pathology, EarlyView.
Abstract Lethal prostate cancer (PCa) is a genetically heterogeneous disease characterized by evolving androgen receptor (AR) signaling, eventually culminating in castration resistance. The tumor suppressor gene BRCA1 has multiple functions that include secondary processes cooperating with its main function as a caretaker of genomic integrity. BRCA1 is
Saiganesh Sriraman   +8 more
wiley   +1 more source

Fibroblast‐specific palladin drives kidney fibrosis via MRTF–SRF signaling

open access: yesThe Journal of Pathology, EarlyView.
Abstract Fibrosis is a common end‐stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin‐related transcription factor (MRTF)–serum response factor (SRF) signaling drives the expression of fibrosis‐related molecules through actin cytoskeleton dynamics in renal fibroblasts.
Naoki Yamamoto   +27 more
wiley   +1 more source

Outpatient dual-energy x-ray osteodensitometry in diagnosis of early disorders of mineral bone density and monitoring of postmenopausal osteoporosis treatment

open access: yesТерапевтический архив, 2009
Aim. To improve quality of densitometric diagnosis of abnormal bone tissue mineral density (BTMD) in postmenopausal women using the results of densitometry of two adjacent lumbar vertebra and proximal regions of both femoral bones.
M P Rubin, M P Rubin
doaj  

A Method for High‐Throughput Screening of Monoclonal Antibody Internalization Using a DNA/Protein Molecular Staple

open access: yesSmall Methods, EarlyView.
Internalization of antibodies plays a critical role in targeted drug delivery and the activity of antibody therapeutics. A simple, one‐pot, chemical modification free approach is developed to quantify antibody internalization into cells. Abstract The use of monoclonal antibodies (mAbs) as therapeutics or for targeted delivery to specific cells is ...
Lara M. Mollé   +4 more
wiley   +1 more source

Acute Inhalation Exposure to Ultrafine Carbon Black Alters Mitochondrial Substrate Utilization in the Heart

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT A majority of deaths associated with air pollution are attributed to cardiovascular and heart diseases. Carbon black that represents the carbon core of particulate matter, a major component of air pollution, has been shown to result in cardiac mitochondrial dysfunction.
William E. Mullen   +4 more
wiley   +1 more source

Bone mineralisation in preterm infants measured by dual energy radiographic densitometry. [PDF]

open access: bronze, 1989
Andrew Lyon   +4 more
openalex   +1 more source

Biomass production of tropical trees across space and time: The shifting roles of diameter growth and wood density

open access: yesJournal of Ecology, EarlyView.
Diameter growth is an important and good indicator of forest carbon production. However, size‐related changes in wood density, which are usually neglected, are critical for accurate short‐ and long‐term carbon assessments, especially in tropical humid sites.
Bruna Hornink   +18 more
wiley   +1 more source

Home - About - Disclaimer - Privacy