Results 81 to 90 of about 248,416 (349)

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Assessment of Early Fuchs Endothelial Corneal Dystrophy and CTG Trinucleotide Expansion Positivity Using Scheimpflug Imaging

Ophthalmology Science
Purpose: To evaluate changes in corneal densitometry and optical aberrations using Scheimpflug imaging in early Fuchs endothelial corneal dystrophy (FECD) and to assess their association with CTG trinucleotide repeat expansion.
Stanley S.J. Poh, MBBS, Kai Yuan Tey, MBBS, Gary S.L. Peh, PhD, Dawn J.H. Neo, MSc, Hla Myint Htoon, PhD, Evan K.L. Lee, Yu Qiang Soh, MBBS, V Vinod Mootha, MD, Jodhbir S. Mehta, PhD   +8 more
doaj   +1 more source

Automatic Quantification of Interstitial Lung Disease From Chest Computed Tomography in Systemic Sclerosis

Frontiers in Medicine, 2020
Background: Interstitial lung disease (ILD) is a common complication in patients with systemic sclerosis (SSc), and its diagnosis contributes to early treatment decisions.Purposes: To quantify ILD associated with SSc (SSc-ILD) from chest CT images using ...
Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho, Alan R. Guimarães, Flávio R. Sztajnbok, Rosana Souza Rodrigues, Rosana Souza Rodrigues, Bruno Rangel Antunes Silva, Agnaldo José Lopes, Walter Araujo Zin, Isabel Almeida, Manuela Maria França   +11 more
doaj   +1 more source

Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1 [PDF]

, 2018
Aberrant transforming growth factor–β (TGF-β) signaling is a hallmark of the stromal microenvironment in cancer. Dickkopf-3 (Dkk-3), shown to inhibit TGF-β signaling, is downregulated in prostate cancer and upregulated in the stroma in benign prostatic ...
A Dutta, A Prudova, B Croix St, C Zenzmaier, C Zenzmaier, CL Busceti, CP Goswami, CP Goswami, CY Fu, D Bello-DeOcampo, D Fong, D Romero, D Romero, D Romero, DA Barron, EJ Tokar, Emmanouil Stylianakis, F Abarzua, F Gao, G Ayala, G Untergasser, Giacomo Domenici, GN Thalmann, H Bauderlique-Le Roy, H Kumon, H Kumon, H Ross-Adams, Hoda Kardooni, Ignacio Zabalza, Irantzu Gorroño-Etxebarria, J Debnath, J Veeck, Jennifer H. Steel, JL Leonard, JN Shah, Jonathan Waxman, JP Webber, L Buscemi, LR Rohrschneider, M Augsten, M Bekhouche, M Hangai, M Piva, M Zhu, Maria dM Vivanco, Miriam Rabano, MM Webber, MP Ween, N Fujimoto, N Yu, P Smits, P Su, Robert M. Kypta, S Dennler, T Li, TD Schmittgen, VE Krupnik, Virginia Murillo-Garzón, VP Montecinos, WY Chen, X Wang, Y Gong, Y Kawano, Y Niu, Z Tu, Zainab Al Shareef   +65 more
core   +2 more sources

CT densitometry in emphysema: a systematic review of its clinical utility

International Journal of COPD, 2018
Background The aim of the study was to assess the relationship between computed tomography (CT) densitometry and routine clinical markers in patients with chronic obstructive pulmonary disease (COPD) and alpha-1 anti-trypsin deficiency (AATD).
Diana Crossley, M. Renton, M. Khan, E. V. Low, A. Turner   +4 more
semanticscholar   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Influencing Factors in Corneal Densitometry Recovery After Accelerated Cross-Linking for Keratoconus

Journal of Ophthalmology
This study examines corneal densitometry recovery and influencing factors following accelerated corneal cross-linking (CXL) for progressive keratoconus.
Kuan-I Huang, Cyuan-Yi Yeh, Chao-Chien Hu, Sheng-Fu Cheng   +3 more
doaj   +1 more source

Morphometric and densitometric characteristics of the brainstem locus coeruleus neurons nuclei in rats with experimental arterial hypertension

Patologìâ, 2019
The aim of our study was to establish the morphodensitometric features of locus coeruleus (LC) neurons nuclei in the brain stem of rats with arterial hypertension of various origin (essential – SHR and endocrine-salt hypertension (ESH)).
O. V. Hancheva, M. V. Danukalo, O. V. Melnikova   +2 more
doaj   +1 more source

Location of the free thiol group in bovine [beta]-lactoglobulin A, B, and C : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 1997
Under non-reducing sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) conditions unheated samples of β-lactoglobulin (β-LG) A, B and C all run as a single band, the A variant having a slightly lower mobility than the B and C variants ...
Brittan, Helen
core  

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source