Results 131 to 140 of about 252,175 (379)

Silver Staining of Proteins in 2DE Gels [PDF]

, 2009
Silver staining detects proteins after electrophoretic separation on polyacrylamide gels. Its main positive features are its excellent sensitivity (in the low nanogram range) and the use of very simple and cheap equipment and chemicals.
Chevallet, Mireille, Lelong, Cécile, Luche, Sylvie, Rabilloud, Thierry   +3 more
core   +5 more sources

Normalization of spine densitometry

Journal of Bone and Mineral Research, 1994
Abstract We investigated several transformations of bone mineral content (BMC) and area density (BMD), in particular volumetric density (BMAD), to ascertain the influence on (1) body size dependence, (2) diagnostic sensitivity, and (3) precision.
R B, Mazess, H, Barden, C, Mautalen, E, Vega   +3 more
openaire   +2 more sources

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Peculiarities of Calcium-Phosphorus Metabolism and Bone State in Patients with Rheumatoid Arthritis: Pathogenesis, Diagnosis and Principles of Differential Treatment (Literature Review and Clinical Case Description)

Львівський клінічний вісник, 2019
Introduction. Significant prevalence of rheumatoid arthritis (RA), an unceasing increase in morbidity, affliction of working age population, late diagnosis, not always effective treatment and large economic damage due to this disease and its ...
Chemes V., Abrahamovych O., Abrahamovych U., Tsyhanyk L., Guta S.   +4 more
doaj   +1 more source

Differential Tissue Response to Growth Hormone in Mice [PDF]

, 2018
Growth hormone (GH) has been shown to act directly on multiple tissues throughout the body. Historically, it was believed that GH acted directly in the liver and only indirectly in other tissues via insulin‐like growth hormone 1 (IGF‐1).
Banerjee, Ronadip R., Berry, Ryan, Frank, Stuart J., McGinnis, Graham R., Young, Martin E.   +4 more
core   +2 more sources

Densitometry

AbstractThis chapter describes various densitometry techniques that involve measurement of photon absorption at a single energy and at multiple energies and measurement of differential photon attenuation across absorption edges. Covered in the chapter include single-line, multiple-energy, absorption-edge, and hybrid K-edge densitometry.
R. Venkataraman, R. McElroy, P. A. Russo, P. A. Santi   +3 more
openaire   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

Advanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang, Xinyun Li, Yong Wang, Chuhe Yang, Xiaopei Gao, Ke Zhu, Yihang Ren, Jingxin Li, Chuanyong Liu, Bing Xue   +9 more
wiley   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Exploring the Synergy Between HPTLC and HPLC-DAD for the Investigation of Wine-Making By-Products

Molecules, 2019
Both environmental and economic issues are increasingly pushing for the revalorization of agri-food by-products, including those arising from wine industry. Wastes produced from wine-making processes are important sources of biologically active compounds,
Tatiana Bernardi, Olga Bortolini, Alessandro Massi, Gianni Sacchetti, Massimo Tacchini, Carmela De Risi   +5 more
doaj   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source