Results 241 to 250 of about 149,082 (291)

Production of human cathepsins using Expi293™ mammalian cell expression system for off‐target activity of cysteine protease inhibitor screening

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Following the SARS‐CoV‐2 pandemic, many direct‐acting antivirals targeting viral cysteine protease were developed. SARS‐CoV‐2, as well as other viruses, rely on cysteine proteases for their replication, suggesting future generations of antivirals targeting cysteine proteases will emerge.
Zoe Turner, Elena Arutyunova, Duong T. Bui, Ling Han, Appan Srinivas Kandadai, Bing Bai, Howard S. Young, Lara K. Mahal, John S. Klassen, M. Joanne Lemieux   +9 more
wiley   +1 more source

FKBP5 Regulates Osteogenesis of Human iPSC‐Derived Mesenchymal Stem Cells via FKBP5‐AKT‐FOXO1 Pathway

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT The induced pluripotent stem cells derived mesenchymal stem cells (iMSCs) have shown great promise for bone tissue regeneration in critical‐sized calvarial defects. Still, the roles of FKBP5 in its osteogenesis are rarely known. It was observed that FKBP5 increased rapidly in iMSCs following osteogenic differentiation.
Xiao‐Yu Tian, Biao Zhu, Xiang‐Bin Zhou, Wen‐Can Fang, Ye Lei, Meng‐Nan Liu, Ning Wu, Ning Wen, Hong Li   +8 more
wiley   +1 more source

Laminin-derived peptide drives the cardiomyogenic potential and cardiac cells functionality. [PDF]

Front Bioeng Biotechnol
Casarella S, Ferla F, Di Francesco D, Pagani V, Di Varsavia C, Regano I, Boccafoschi F.   +6 more
europepmc   +1 more source

Early postoperative changes in corneal densitometry after SMILE with 120-μm and 130-μm cap thickness: a comparative study. [PDF]

Adv Ophthalmol Pract Res
Wu S, Jin H, Wan T.
europepmc   +1 more source

SIRT1 retention in elongating spermatids interferes with histone displacement by counteracting MOF-dependent H4K16 acetylation. [PDF]

Front Cell Dev Biol
Porreca V, Chioccarelli T, Albano F, Nittoli V, Ricci G, Ambrosino C, Chianese R, Mele VG, Migliaccio A, Stornaiuolo M, Suglia A, Cobellis G, Manfrevola F.   +12 more
europepmc   +1 more source

MT2 receptor mediates melatonin-induced thermogenic program in human myoblasts: insights for circadian syndrome and diabesity treatment. [PDF]

Front Pharmacol
Salagre D, Sanjuán-Hidalgo J, Elmahallawy EK, Medina PP, Agil A.   +4 more
europepmc   +1 more source

Effect of metformin in a novel experimental model of peripheral artery disease. [PDF]

Clin Sci (Lond)
Krishna SM, Moxon J, Kraeuter AK, Golledge J.   +3 more
europepmc   +1 more source

Activin-A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type-II Receptor Expression. [PDF]

Pulm Circ
Dunmore BJ, Kikuchi N, Li W, Upton PD, Morrell NW.   +4 more
europepmc   +1 more source

Cardioprotection Through Pharmacological Activation of Sirtuin 5 in a Murine Model of Acute Myocardial Infarction. [PDF]

Drug Des Devel Ther
Castiello C, Efentakis P, Nikolaou PE, Symeonidi L, Chania C, Barla I, Akrani I, Kostomitsopoulos N, Gikas E, Thomaidis NS, Mikros E, Kleinbongard P, Fioravanti R, Zwergel C, Valente S, Mai A, Andreadou I.   +16 more
europepmc   +1 more source