Results 241 to 250 of about 224,534 (289)

Cyclic GMP-AMP synthase deficiency predisposes the liver to alcohol-induced cell death and ER stress. [PDF]

Hepatol Commun
Babuta M, Datta AA, de Carvalho Ribeiro M, Santos BACD, Morel C, Copeland C, Ortega-Ribera M, Mehta J, Calenda C, Wang Y, Remotti V, Brezani V, Patel A, Hawryluk D, Szabo G.   +14 more
europepmc   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Visual, Topographic and Aberrometric Outcomes After Phototherapeutic Keratectomy (PTK) for Salzmann Nodular Degeneration. [PDF]

Med Sci (Basel)
Helm S, Wiedemann J, Reinking N, Rosswinkel B, Bachmann B, Cursiefen C, Schlereth S.   +6 more
europepmc   +1 more source

Skeletal muscle myosin heavy chain fragmentation following exercise may be linked to post‐exercise inflammation and remodelling

Experimental Physiology, EarlyView.
Abstract The purpose of this exploratory investigation was to determine if acute post‐exercise skeletal muscle myosin heavy chain fragmentation (MyHCfrag) coincides with alterations in molecular chaperones and proteolytic enzymes, select markers of mammalian target of rapamycin complex 1 (mTORC1) signalling, and/or specific gene expression signatures ...
Dakota R. Tiede, Diego Bittencourt, J. Max Michel, Daniel L. Plotkin, Madison L. Mattingly, Derick A. Anglin, Christopher G. Vann, Zachary A. Graham, Timothy J. Broderick, Marcas M. Bamman, Michael D. Roberts   +10 more
wiley   +1 more source

CCN1 drives asthmatic airway remodeling through amplification of TGF-β1/Smad3 signaling. [PDF]

Respir Res
Wang Y, Xu C, Zeng R, Liu X, Zhang J, Pan Y, Qi Q, Qiao C, Shi S, Wang P, Liu X, Gao M, Gao T, Dong L.   +13 more
europepmc   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

CXCL5 neutralization mitigates cancer cachexia by disrupting CAF-cancer cell crosstalk. [PDF]

J Biomed Sci
Kim HJ, Kim SW, Kim JH, Lee SH, Joo KH, Lee SY, Lee H, Min JJ, Cho SH, Jung DW, Williams DR.   +10 more
europepmc   +1 more source

HDAC11 promotes renal fibrosis by induing partial epithelial-mesenchymal transition and G2/M phase arrest in renal epithelial cells. [PDF]

Mol Med
Guan Y, Shen F, Yao L, Chang M, Zhao TC, Zhuang S.   +5 more
europepmc   +1 more source

Thiamine transporter 2 and Janus kinase 2 inhibitor, fedratinib suppresses thermogenic activation of human neck area-derived adipocytes. [PDF]

Front Endocrinol (Lausanne)
Karadsheh G, Kovács E, Alrifai R, Seo M, Győry F, Csatári-Kovács R, Csősz É, Póliska S, Fésüs L, Arianti R, Kristóf E.   +10 more
europepmc   +1 more source

SUMOylation Protects Endothelial Cell-Expressed Leukocyte-Specific Protein 1 from Ubiquitination-Mediated Proteasomal Degradation and Facilitates Its Nuclear Export. [PDF]

Int J Mol Sci
Hossain M, Huang J, Su Y, Islam MR, Rahman MA, Cayabyab FS, Liu L.   +6 more
europepmc   +1 more source