Results 41 to 50 of about 149,082 (291)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Measuring of Mandible Bone Density in Dogs Using /Digital Radiography/ Radiovisigraphy

Acta Veterinaria, 2020
Radiological diagnostics serves as one of the basic monitoring techniques in veterinary dental practice. The recent up-to-date literature data based on the findings of digital radiology/radiovisiography (RVG) in general dentistry inspired the authors to ...
Ilić Dragan, Stojanović Ljiljana, Antonijević Djordje, Milutinović-Smiljanić Sanja, Savić-Stanković Tatjana, Milosavljević Željko   +5 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Evaluation of bone mineral density and biochemical markers in pediatric patients with phenylketonuria

Molecular Genetics and Metabolism Reports
Objectives: Phenylketonuria is a hereditary condition caused by the deficiency of the enzyme phenylalanine hydroxylase, leading to abnormal phenylalanine metabolism.
Akram Ehsasat Vatan, M.D., Amin Mottaghizade Gargari, M.D., Arian Haghtalab, M.D., Nima Ebrahimpour Seraydar, M.D.   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Automatic Quantification of Interstitial Lung Disease From Chest Computed Tomography in Systemic Sclerosis

Frontiers in Medicine, 2020
Background: Interstitial lung disease (ILD) is a common complication in patients with systemic sclerosis (SSc), and its diagnosis contributes to early treatment decisions.Purposes: To quantify ILD associated with SSc (SSc-ILD) from chest CT images using ...
Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho, Alan R. Guimarães, Flávio R. Sztajnbok, Rosana Souza Rodrigues, Rosana Souza Rodrigues, Bruno Rangel Antunes Silva, Agnaldo José Lopes, Walter Araujo Zin, Isabel Almeida, Manuela Maria França   +11 more
doaj   +1 more source

Cations Do Not Alter the Membrane Structure of POPC—A Lipid With an Intermediate Area

Frontiers in Molecular Biosciences, 2022
Combining small-angle neutron scattering (SANS), small-angle X-ray scattering (SAXS), and densitometric measurements, we have studied the interactions of the divalent cations Ca2+ and Mg2+ with the lipid vesicles prepared of a mixed-chain palmitoyl ...
Sergei Kurakin, Sergei Kurakin, Oleksandr Ivankov, Vadim Skoi, Vadim Skoi, Alexander Kuklin, Alexander Kuklin, Daniela Uhríková, Norbert Kučerka, Norbert Kučerka   +9 more
doaj   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Morphometric and densitometric characteristics of the brainstem locus coeruleus neurons nuclei in rats with experimental arterial hypertension

Patologìâ, 2019
The aim of our study was to establish the morphodensitometric features of locus coeruleus (LC) neurons nuclei in the brain stem of rats with arterial hypertension of various origin (essential – SHR and endocrine-salt hypertension (ESH)).
O. V. Hancheva, M. V. Danukalo, O. V. Melnikova   +2 more
doaj   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source