Results 51 to 60 of about 248,416 (349)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Linking layered corneal compactness to macroscopic biomechanics: in vivo assessment via integrated densitometry and dynamic deformation analysis

Frontiers in Bioengineering and Biotechnology
ObjectiveTo investigate in vivo correlations between corneal dynamic deformation properties and structural compactness via layered densitometry, clarifying the main contributions of the corneal anatomical layers to macroscopic biomechanics.DesignCross ...
Fuqi Deng, Fuqi Deng, Fuqi Deng, Huazheng Cao, Wenjing Gao, Wenjing Gao, Wenjing Gao, Wenjing Gao, Caohui Xu, Caohui Xu, Caohui Xu, Li Li, Li Li, Ping Lu, Ping Lu, Yan Wang, Yan Wang, Yan Wang   +17 more
doaj   +1 more source

The influence of continuous magnetic field on periodontal tissues under overdentures [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2009
Introduction. Last remained teeth with reduced alveolar support do not have long-term prognosis, which is the reason for prolonging the life and thus providing a stable support of overdenture. The data from literature point out that static magnetic field
Brković-Popović Snežana, Stamenković Dragoslav, Stanišić-Sinobad Darinka, Rakočević Zoran, Zelić Obrad   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Processing peptidase of Neurospora mitochondria [PDF]

, 1984
Subunit 9 (dicyclohexylcarbodiimide binding protein, 'proteolipid') of the mitochondrial F1F0-ATPase is a nuclearly coded protein in Neurospora crassa.
Neupert, Walter, Schmidt, Bernd, Sebald, Walter, Wachter, Elmar   +3 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Weak Lensing by High-Redshift Clusters of Galaxies - I: Cluster Mass Reconstruction

, 2000
We present the results of a weak lensing survey of six high-redshift (z > 0.5), X-ray selected clusters of galaxies. We have obtained ultra-deep R-band images of each cluster with the Keck Telescope, and have measured a weak lensing signal from each ...
Bartelmann M., D. Clowe, Eke V. R., Ellis R. S., Fischer P., G. A. Luppino, I. M. Gioia, Kaiser N., N. Kaiser, Neumann D. M., Reblinsky K., Schneider P., Seitz C., Smail I.   +13 more
core   +1 more source

Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. [PDF]

, 2018
The role of distinct actin filament architectures in epithelial plasticity remains incompletely understood. We therefore determined roles for formins and the Arp2/3 complex, which are actin nucleators generating unbranched and branched actin filaments ...
Aloisio, Francesca M, Barber, Diane L, Choi, Changhoon, Rana, Manish K   +3 more
core   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Correlations between Retinal Arterial Morphometric Parameters and Neurodegeneration in Patients with Type 2 Diabetes Mellitus with No or Mild Diabetic Retinopathy

Medicina, 2021
Background and Objectives: In patients with diabetes mellitus (DM), the neural retina is starting to degenerate before the development of vascular lesions.
Ioana Damian, Simona Delia Nicoară
doaj   +1 more source