Results 101 to 110 of about 7,360,473 (315)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Tunable Plasmonic Bandwidth Broadening via DC Electrical Bias

Nanomaterials
The ability to broaden the bandwidth of nanodevices holds significant promise for applications in modern science and technology. In this work, we demonstrate a tunable approach to the bandwidth modulation of nanoresonators by applying a direct current ...
Chen Wei, Fuhua Gao, Fan Yang
doaj   +1 more source

Typical density profile for warm dark matter haloes [PDF]

, 2012
Jordi Viñas, Eduard Salvador-Solé, Alberto Manrique   +2 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Wave Energy Conversion Technology Based on Liquid Metal Magnetohydrodynamic Generators and Its Research Progress

Energies
Wave energy is a highly concentrated energy resource with five times higher energy density than wind and at least ten times the power density of solar energy.
Lingzhi Zhao, Aiwu Peng
doaj   +1 more source

Effects of High-Impact Weight-Bearing Exercise on Bone Mineral Density and Bone Metabolism in Middle-Aged Premenopausal Women: A Randomized Controlled Trial [PDF]

, 2021
Sung-Woo Kim, Myong-Won Seo, Hyun Chul Jung, Jong-Kook Song   +3 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Experimental Study of an Evaporative Cooling System in a Rotating Vertical Channel with a Circular Cross-Section for Large Hydro-Generators

Energies
With the evolution of hydroelectric generators toward larger capacity and higher rotational speeds, the significa++nt increase in power density has rendered rotor cooling technology a critical bottleneck restricting performance enhancement.
Ruiwei Li, Lin Ruan
doaj   +1 more source

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

Clinical Chemistry, 1972
W. T. Friedewald, R. Levy, D. Fredrickson   +2 more
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source