Results 51 to 60 of about 2,179,940 (251)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Does Clade Density Constrain Geographical Range Evolution?

Ecology and Evolution
ABSTRACTThe role of biotic interactions, such as interspecific competition, in driving geographical range evolution is still poorly understood. For instance, lineages distributed across regions with a large number of potential competitors might experience some level of geographical packing of their range limits, so that changes in their geographical ...
Marcio R. Pie, Raquel Divieso, Fernanda S. Caron   +2 more
openaire   +4 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The Effect of Saturation on Belief Propagation Decoding of LDPC Codes

, 2014
We consider the effect of LLR saturation on belief propagation decoding of low-density parity-check codes. Saturation occurs universally in practice and is known to have a significant effect on error floor performance.
Iyengar, Aravind, Kudekar, Shrinivas, Richardson, Tom   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Analytically solvable model of a driven system with quenched dichotomous disorder

, 2007
We perform a time-dependent study of the driven dynamics of overdamped particles which are placed in a one-dimensional, piecewise linear random potential.
A. P. Prudnikov, B. V. Gnedenko, E. S. Denisova, M. Kostur, N. G. Van Kampen, P. Hänggi, S. I. Denisov, Ya. G. Sinai   +7 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Constraining reionization using the thermal history of the baryons [PDF]

, 2000
The thermal evolution of the intergalactic medium (IGM) depends on the reionization history of the universe. Numerical simulations indicate that the low density IGM, which is responsible for the low column density Ly-alpha forest, follows a well defined ...
Efstathiou, G., J.Franco, L.Terlevich, O.López-Cruz, \& I.Aretxaga, Rauch, M., Sargent, W.L.W., Schaye, J., Theuns, T.   +6 more
core   +1 more source

The density evolution of IRAS galaxies

The Astrophysical Journal, 1992
A maximum likelihood test for density evolution is applied to a full-sky redshift survey of 5297 galaxies selected from the IRAS data base and flux-limited at 1.2 Jy. No evidence for evolution is found. Attention is given to important systematic errors which decrease the certainty with which evolution can be measured, namely, limited knowledge of the ...
Karl B. Fisher, Michael A. Strauss, Marc Davis, Amos Yahil, John P. Huchra   +4 more
openaire   +1 more source