Results 71 to 80 of about 2,179,940 (251)

Stochastic Biasing and Galaxy-Mass Density Relation in the Weakly Non-linear Regime

, 1999
It is believed that the biasing of the galaxies plays an important role for understanding the large-scale structure of the universe. In general, the biasing of galaxy formation could be stochastic.
Chodorowski M. J., Mo H. J., Mo H. J.
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Bone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia: A Leucémies Enfants Adolescents Study. [PDF]

Hemasphere, 2021
Tabone MD, Kolta S, Auquier P, Vercasson C, Chastagner P, Kanold J, Rohrlich PS, Bertrand Y, Baruchel A, Plantaz D, Gandemer V, Ducassou S, Petit A, Paillard C, Leverger G, Dalle JH, Berbis J, Roux C, Michel G.   +18 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Low-x evolution of parton densities

, 2012
It is shown that a Bessel-like behaviour of the structure function F2 at small x, obtained for a flat initial condition in the DGLAP evolution equations, leads to good agreement with the deep inelastic scattering experimental data from HERA.
Illarionov, Alexey Yu., Kotikov, Anatoly V.   +1 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

On the Evolution of the Cores of Radio Sources and Their Extended Radio Emission

, 2011
The work in this paper aims at determining the evolution and possible co-evolution of radio-loud active galactic nuclei (AGNs) and their cores via their radio luminosity functions (i.e., total and core RLF respectively).
Antonucci, Athreya, Baker, Blundell, Browne, Burgess, Burgess, Carilli, Colla, Croston, di Serego-Alighieri, Dicken, Dodson, Drinkwater, Dunlop, Ekers, Ellis, Falcke, Falcke, Fanaroff, Fanti, Feretti, Ficarra, Giovannini, Govoni, Hardcastle, Ho, Hogg, Jiancheng Wang, Jiang, Jones, Kapahi, Kapahi, Kuehr, Laing, Laing, Large, Large, Leipski, Longair, Mantovani, Marshall, Metcalfe, Miyaji, Morganti, Morganti, Rafter, Reid, Sadler, Saikia, Sikora, Singal, Slee, Tadhunter, Venturi, Verdoes Kleijn, Vigotti, Wall, Wright, Zunli Yuan   +59 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source