Results 91 to 100 of about 3,730,095 (253)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Nonlinear cross Gramians and gradient systems [PDF]
, 2007 We study the notion of cross Gramians for non-linear gradient systems, using the characterization in terms of prolongation and gradient extension associated to the system.
Jacquelien M. A. Scherpen +5 more
core +2 more sources
Stress Distribution in Graded Cellular Materials Under Dynamic Compression
Latin American Journal of Solids and StructuresDynamic compression behaviors of density-homogeneous and density-graded irregular honeycombs are investigated using cell-based finite element models under a constant-velocity impact scenario.
Peng Wang +3 more
doaj +1 more source
A quick and large-scale density gradient subfractionation method for low density lipoproteins.
Journal of Lipid Research, 1982 A quick density gradient-banding subfractionation method has been developed for d < 1.063 g/ml lipoproteins. Up to 324 ml of plasma can be resolved into five distinct layers by a single ultracentrifugation.
D M Lee, D Downs
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Intercomparison of snow density measurements: bias, precision, and vertical resolution [PDF]
, 2016 Density is a fundamental property of porous media such as snow. A wide range of snow properties and physical processes are linked to density, but few studies have addressed the uncertainty in snow density measurements.
C. Fierz +7 more
core +2 more sources
OptiPrepTM Density Gradient Solutions for Nonmammalian Organelles
The Scientific World Journal, 2002 Any density gradient for the isolation of nonmammalian organelles should ideally only expose the sedimenting biological particles to an increasing concentration of the gradient solute.
John M. Graham
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Density and the Journey to Work [PDF]
This paper evaluates the influence of residential density on commuting behavior across U.S. cities while controlling for available opportunities, the technology of transportation infrastructure, and individual socio-economic and demographic ...
Ajay Kumar, David Levinson
core