Results 101 to 110 of about 3,730,095 (253)

Gelatin Density Gradient for Isolation of Islets of Langerhans

Cell Transplantation, 1998
Isolation of islets of Langerhans (islets) has been performed by means of collagenase digestion of the pancreatic tissue combined with density gradient separation of islets from unwanted exocrine tissues.
Tadashi Samejima, Kenji Yamaguchi, Hiroo Iwata, Noriyuki Morikawa, Yoshito Ikada   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cities with suburbs: Evidence from India. [PDF]

For a country like India that contains a large number of Urban Agglomerations (UAs), suburbanisation has drawn little attention of the literature. I focus on this sparsely studied issue in this work.
Sridhar, Kala Seetharam
core  

The Growth and Structure of Double - Diffusive Cells Adjacent to a Side - Wall in a Salt - Stratified Environment [PDF]

, 2004
August 15-21, 2004 Measurements are reported of the rate of horizontal extension of the cells in tanks of different lengths with a range of initial salinity gradients and cooling rates (which determine the vertical height of each cell).
Phillips, OM, Malki-Epshtein, L, Huppert, HE   +2 more
core  

Analysis of Mechanical Properties and Microscopic Discrete Element Study of Foam Concrete under Dry-Wet Cycles

Zhongwai Gonglu
To reveal the effects of the number of dry-wet cycles and the material density gradient on the deterioration laws of macroscopic mechanical properties, microscopic damage mechanisms, and failure modes of foam concrete, foam concrete test blocks with ...
XU Ke, ZHANG Jun, KUANG Yuyang
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Earthworm Species from Diverse Ecological Groups Negatively Affect Enchytraeid Density in a Forest Ecosystem

Biology
Earthworms and enchytraeids are two very important groups of soil organisms that influence soil biology and ecology, as well as physicochemical processes occurring in the soil.
Kamil Karaban, Anita Kaliszewicz, Krassimira Ilieva-Makulec, Alexei V. Uvarov   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Assumptions about the dynamics sources and mechanisms of plate tectonic activities

Frontiers in Earth Science
The problem of the driving source and power mechanism of plate motion remains a major scientific issue in urgent need of resolution. Based on the isostatic hypothesis model proposed by G.B.
Ziyun Chen, Ziyun Chen, Tianbin Li, Meiben Gao, Wei Chen   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source