Results 71 to 80 of about 1,778,097 (289)

Underdense plasma lens with a transverse density gradient

Physical Review Accelerators and Beams, 2023
We explore the implications of a transverse density gradient on the performance of an underdense plasma lens and nonlinear plasma-based accelerator. Transverse density gradients are unavoidable in plasma sources formed in the outflow of standard gas jets,
C. E. Doss, R. Ariniello, J. R. Cary, S. Corde, H. Ekerfelt, E. Gerstmayr, S. J. Gessner, M. Gilljohann, C. Hansel, B. Hidding, M. J. Hogan, A. Knetsch, V. Lee, K. Marsh, B. O’Shea, P. San Miguel Claveria, D. Storey, A. Sutherland, C. Zhang, M. D. Litos   +19 more
doaj   +1 more source

Quantitative Analysis of CME Deflections in the Corona

, 2011
In this paper, ten CME events viewed by the STEREO twin spacecraft are analyzed to study the deflections of CMEs during their propagation in the corona.
Gui, Bin, Liu, Jiajia, Shen, Chenglong, Wang, Shui, Wang, Yuming, Ye, Pinzhong, Zhao, Xuepu   +6 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology

Journal of Extracellular Vesicles, 2019
Extracellular vesicles have the capacity to transfer lipids, proteins, and nucleic acids between cells, thereby influencing the recipient cell’s phenotype.
Elisa Lázaro-Ibáñez, Cecilia Lässer, Ganesh Vilas Shelke, Rossella Crescitelli, Su Chul Jang, Aleksander Cvjetkovic, Anaís García-Rodríguez, Jan Lötvall   +7 more
doaj   +1 more source

COMPARISON BETWEEN TWO-LAYER DENSITY GRADIENT AND THREE-LAYER DENSITY GRADIENT TECHNIQUE FOR SPERM PREPARATION AT ASTER FERTILITY CLINIC, DR. HASAN SADIKIN GENERAL HOSPITAL

International Journal of Integrated Health Sciences, 2014
Objective: To compare the efficacy of sperm preparation techniques modified by two layer density gradient technique (80%, 40%). Methods: Sperm preparation was performed by two- and three-layer density gradient technique by centrifugation at 500 rpm ...
Nanang Winarto Astarto, Dian Tjahyadi, Sintya Jatnikasari   +2 more
doaj   +1 more source

Local Behavior of the First-Order Gradient Correction to the Thomas-Fermi Kinetic Energy Functional

, 2009
The first order gradient correction to the Thomas-Fermi functional, proposed by Haq, Chattaraj and Deb (Chem. Phys. Lett. vol. 81, 8031, 1984) has been studied by evaluating both the total kinetic energy and the local kinetic energy density.
Atkins P. W., David García-Aldea, Fermi E., J. E. Alvarellos, Kirzhnits D. A., T. Martín-Blas   +5 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Exact condition on the Kohn-Sham kinetic energy, and modern parametrization of the Thomas-Fermi density

, 2008
We study the asymptotic expansion of the neutral-atom energy as the atomic number Z goes to infinity, presenting a new method to extract the coefficients from oscillating numerical data.
Donghyung Lee, John P. Perdew, Karasiev V. V., Kieron Burke, Kirzhnits D. A., Lucian A. Constantin, Perdew J. P., Press W. H., Wang Y. A.   +8 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source