Adaptive minimum bit-error-rate filtering
Adaptive filtering has traditionally been developed based on the minimum mean square error (MMSE) principle and has found ever-increasing applications in communications. The paper develops adaptive filtering based on an alternative minimum bit error rate
Chen, S.
core +1 more source
The imprint of crustal density heterogeneities on regional seismic wave propagation [PDF]
Density heterogeneities are the source of mass transport in the Earth. However, the 3-D density structure remains poorly constrained because travel times of seismic waves are only weakly sensitive to density.
A. Fichtner +7 more
core +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Measuring the performance of recent generalized gradient approximations to density functional theory in molecules and solids [PDF]
Density functional theory is a successful theory used in physics, chemistry and nanoscience to describe the ground state properties of solids and molecules. It calculates ground state energies and related properties by using the density of the valence
Ross, Seth L.
core
Optimization of in vitro fertilization with X-sorted spermatozoa in cattle
IntroductionDairy farming has a preferential demand for female calves to sustain milk production. Spermatozoa carrying the X chromosome, selected based on the higher content in DNA, allow to obtain almost exclusively female offspring.
Fernanda Fagali Franchi +8 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Gradient-Domain Photon Density Estimation
The most common solutions to the light transport problem rely on either Monte Carlo (MC) integration or density estimation methods, such as uni- & bi-directional path tracing or photon mapping.
Hua, Binh-Son +3 more
core +1 more source

