Results 141 to 150 of about 6,470,188 (388)

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Fractionating microplastics by density gradient centrifugation: a novel approach using LuerLock syringes in a low-cost density gradient maker

Chemistry Teacher International
Microplastics are now ubiquitous in the environment and are even considered “technofossils” of the Anthropocene. Given their omnipresence and potential impact, identifying and analyzing these particles becomes increasingly crucial.
Majcen Alina, Gohla Jan, Steinhoff Anna S., Meißner Lena, Tassoti Sebastian, Spitzer Philipp   +5 more
doaj   +1 more source

Density Gradient Apparatus [PDF]

Science, 1973
openaire   +2 more sources

Separation of Metallic and Semiconducting Single-Walled Carbon Nanotubes by Density Gradient Ultracentrifugation [PDF]

, 2013
Min Lang, Yongfu Lian
openalex   +1 more source

The 3d-Printed Building and Performance of Al2o3 Ceramic Filters with Gradient Hole Density Structures

, 2023
Guangxu Zhang, Bin Zou, Xinfeng Wang, Yang Yu, Chuanzhen Huang, Hongtao Zhu, Peng Yao, Hanlian Liu   +7 more
openalex   +1 more source

Advancing Image Object Detection: Enhanced Feature Pyramid Network and Gradient Density Loss for Improved Performance [PDF]

, 2023
Ying Wang, Qinghui Wang, Ruirui Zou, Falin Wen, Fenglin Liu, Yihang Zhang, Shaoyi Du, Wei Zeng   +7 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Purification of Adenovirus by Cesium Chloride Density Gradients [PDF]

, 2012
Huan Pang
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source