Results 101 to 110 of about 12,770 (234)

The Interplay of M1 Macrophages and Dental Pulp Stem Cells Promotes Angiogenesis Through IL‐8‐Dependent VEGF Regulation: An In Vitro Study

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp inflammation triggers immune responses involving macrophages and dental pulp stem cells (DPSCs), which interact to regulate angiogenesis essential for tissue repair. M1 pro‐inflammatory macrophages predominate early in pulpitis, and clarifying their angiogenic role is vital in identifying inflammatory regenerative ...
Dineshi Sewvandi Thalakiriyawa   +5 more
wiley   +1 more source

Distinct Microbiota and Functional Pathway Profiles Define Success and Failure in Regenerative Endodontic Treatment

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim To characterize the intracanal microbiota and identify key microbial taxa and functional pathways associated with regenerative endodontic treatment (RET) outcomes. Methodology In this observational cohort study, 196 samples were collected at five time points from external tooth surfaces (T1, T4) and root canals (T2, T3, T5).
Leimarembi Devi Naorem   +7 more
wiley   +1 more source

Short‐Term Outcomes of Full Pulpotomy Compared With Root Canal Treatment for Irreversible Pulpitis: The PROVE Study

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Objectives To assimilate data from individual randomised trials and perform a pooled analysis of short‐term outcomes of pulpotomy compared with root canal treatment (RCT) for teeth with symptomatic irreversible pulpitis (SIRP). Methods Randomised trials were conducted in eight countries using a standardised clinical protocol and outcome ...
I. A. El Karim   +16 more
wiley   +1 more source

Cellular Dynamics and Dentine Bridge Formation Following Direct Pulp Capping With MTA and Biodentine in a Murine Model

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim Formation of a mineralized dentine bridge is the hallmark of successful direct pulp capping (DPC). Mineral trioxide aggregate (MTA) and Biodentine are widely used capping materials, but in vivo evidence comparing their regenerative potential remains inconclusive. This study used a controlled murine model to compare dentine bridge formation
Amnah Sajdeya   +4 more
wiley   +1 more source

Can Artificial Intelligence Be Utilised to Develop Point‐of‐Care Endodontic Microbiological Technologies?

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley   +1 more source

Histopathologic Validity and Clinical Reliability of Wolters Classification of Pulpitis: An Exploratory Study

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim Wolters' classification of pulpitis has been proposed to classify pulpitis into 4 categories (initial, mild, moderate, severe), aiming to guide clinicians to implement the relevant vital endodontic treatment. The main objective of this study was to test the histologic validity and clinical reliability of the Wolters classification ...
Çağla Fatmanur Yılmaz   +3 more
wiley   +1 more source

Endodontic Treatment of Apical Periodontitis Mitigates Systemic Inflammation and Restores the Blood–Brain Barrier Integrity in an In Vitro Model

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim A growing body of research supports an association between periapical inflammation and an increased risk of various systemic effects. However, there is currently no scientific evidence demonstrating a causal relationship between this inflammation and changes in epithelial or endothelial permeability in patients with apical periodontitis ...
Loredana Bergandi   +9 more
wiley   +1 more source

Revascularization Treatment of Immature Permanent Tooth with Necrotic Pulp: A Case Report

open access: yesJournal of Islamic Dental Association of Iran, 2018
Introduction: Revascularization is the newest treatment proposed for an immature permanent tooth with necrotic pulp. Revascularization is defined as a treatment process with a biological base which is aimed at replacing the lost structures and the ...
Bahman Seraj   +2 more
doaj  

From Virtual Modelling to Smarter Endodontic Innovation: In Silico Research for Translational Decision Making

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim To discuss how in silico research may function as an early translational decision layer in endodontics by supporting the prioritisation of hypotheses, technologies and experimental conditions before biological and clinical validation. Summary Endodontic outcomes emerge from interacting anatomical, mechanical, chemical, microbial and host ...
José Evando da Silva‐Filho   +1 more
wiley   +1 more source

High‐Fat Diet Reprograms the Periapical Immune Landscape in a Mouse Model of Apical Periodontitis: A Spatial Transcriptomics Study

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Introduction Apical periodontitis (AP) is an inflammatory disease of the periapical tissues driven by host responses to endodontic infection, and systemic metabolic disturbances, such as high‐fat diet (HFD)–induced dysmetabolism, may exacerbate tissue destruction. This study aimed to determine how chronic HFD exposure alters periapical myeloid
Maryam Ghaffari   +3 more
wiley   +1 more source

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