A detailed structural analysis of the juvenile swine ventricular–subventricular zone reveals four distinct cellular layers and diverse neuroblast migration routes, including pathways toward the olfactory bulb and cortical regions. These features underscore the swine brain's value as a translational model for studying postnatal neurogenesis in large ...
Lucía Inés Torrijos‐Saiz+6 more
wiley +1 more source
GATA Transcription Factors: A Cross‐Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies
ABSTRACT Alpha‐synuclein (α‐syn), a 140 amino acid protein, is abundantly expressed in the central nervous system (CNS) and in the erythrocytes, playing a pivotal role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies.
Francesco Bellomi+7 more
wiley +1 more source
Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy
Gain-of-function mutations in SCN8A cause developmental and epileptic encephalopathy (DEE), a disorder characterized by early-onset refractory seizures, deficits in motor and intellectual functions, and increased risk of sudden unexpected death in ...
Wenxi Yu+6 more
doaj
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits [PDF]
Jorge J. Palop+7 more
openalex +1 more source
On How the Dentate Gyrus Contributes to Memory Discrimination
Milenna T. van Dijk, A. Fenton
semanticscholar +1 more source
Developmental Disturbances in Animal Models of Autism Spectrum Disorder
ABSTRACT Although the early signs of autism spectrum disorder (ASD) are widely studied, the significant ambiguity and heterogeneity in symptoms require the comparison of available models, approaches, and the search for common denominators and key indicators.
Kristof Laszlo+3 more
wiley +1 more source
“Dormant basket cell” hypothesis revisited: Relative vulnerabilities of dentate gyrus mossy cells and inhibitory interneurons after hippocampal status epilepticus in the rat [PDF]
Robert S. Sloviter+5 more
openalex +1 more source
ABSTRACT Alzheimer's disease (AD) is one of the most common neurodegenerative disorders characterized by the accumulation of amyloid‐β (Aβ) peptide and phosphorylated tau protein in the brain. Despite intensive efforts, early diagnosis and monitoring of AD remain challenging due to the lack of reliable biomarkers that can detect the disease in its ...
Ceren Perihan Gonul+2 more
wiley +1 more source
Focal Adhesion Kinase Is Required, But Not Sufficient, for the Induction of Long-Term Potentiation in Dentate Gyrus NeuronsIn Vivo [PDF]
Ying Yang+4 more
openalex +1 more source