Results 251 to 260 of about 139,984 (307)

Manipulating Engram Histone Acetylation Alters Memory Consolidation

Hippocampus, Volume 35, Issue 6, November 2025.
ABSTRACT The epigenome provides the brain with a nucleus‐templated form of plasticity that is of fundamental importance for learning and memory. Of the various types of epigenetic modifications, elevations in histone acetylation have been shown to accompany learning and memory, yet the role this epigenetic modification plays within specific cell ...
Lisa Watt, Liliane Glauser, Davide M. Coda, Johannes Gräff   +3 more
wiley   +1 more source

Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice

Canela M, Adell JB, Coll DR, González-Parra JA, Pinho JS, Busquets-García A.   +5 more
europepmc   +1 more source

Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice. [PDF]

Neuropsychopharmacology
Zhou BY, Li ZX, Li YW, Li JN, Liu WT, Liu XY, Hu ZB, Zhao L, Chen JY, Hu L, Song NN, Feng X, Wang G, Xu L, Ding YQ.   +14 more
europepmc   +1 more source

Altered Coding of Environmental Boundaries in Human Aging: An fMRI Study

Hippocampus, Volume 35, Issue 6, November 2025.
ABSTRACT Aging is associated with changes in spatial memory and navigation, yet the mechanisms underlying these changes are not yet fully understood. Environmental boundaries are among the most salient and reliable spatial cues, supporting both spatial memory and orientation. Here, we investigated how aging affects the use and the neural representation
Vladislava Segen, Matthias Stangl, Jonathan Shine, Thomas Wolbers   +3 more
wiley   +1 more source

Effects of Testosterone and Its Major Metabolites upon Different Stages of Neuron Survival in the Dentate Gyrus of Male Rats. [PDF]

Biomolecules
Spritzer MD, Roy EA, Calhoun KMK, Schneider-Lynch ZE, Panella L, Michaelcheck C, Qian A, Kelly ED, Barr H, Hall E, Cunningham B, Nguyen HHM, Xu D, Barker JM, Galea LAM.   +14 more
europepmc   +1 more source

Notes on the History of In Vitro Hippocampal Electrophysiology and LTP: Personal Reflections

Hippocampus, Volume 35, Issue 6, November 2025.
ABSTRACT This essay describes the development of the in vitro hippocampal slice technique and my small contributions to it and to influencing Roger Nicoll's early interests in the hippocampus and LTP. My Ph.D. work at Harvard with Timothy Teyler was on field potential studies of synaptic plasticity, including LTP, in the rat in vitro hippocampal slice.
Bradley E. Alger
wiley   +1 more source

Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures. [PDF]

Front Neurosci
Granados-Rojas L, Hernández-López L, Bahena-Alvarez EL, Juárez-Zepeda TE, Custodio V, Martínez-Galindo JG, Jerónimo-Cruz K, Tapia-Rodríguez M, Vanoye-Carlo A, Duran P, Rubio C.   +10 more
europepmc   +1 more source

Distinct Patterns of Evoked Firing in Engram and Non‐Engram Neurons in the Dentate Gyrus of Hippocampal Slices

Hippocampus, Volume 35, Issue 6, November 2025.
ABSTRACT Intense electrical activity modifies the cellular properties of neurons to enable the nervous system to store information. The dentate gyrus (DG) plays a role in learning and memory and its principal cell type, the granule cell (GC), can fire vigorously during behavior.
Wen‐Chi Shu, Meyer B. Jackson
wiley   +1 more source

Obituary: Jose Manuel García‐Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers

Journal of Comparative Neurology, Volume 533, Issue 11, November 2025.
Arantxa Cebrian‐Silla, Mercedes Paredes, Arturo Alvarez‐Buylla   +2 more
wiley   +1 more source

HIF‐1 Targeting Intervention Renders Protection From Alzheimer's‐Like Pathology in a Humanized Mice Model of HIV Infection

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
This study explored the use of astrocyte‐derived extracellular vesicles (ADEVs) to deliver siRNA targeting HIF‐1α in HIV‐infected humanized mice, aiming to combat HIV‐associated Alzheimer's‐like pathology and associated synaptodegeneration. Intranasal delivery of these vesicles effectively reached key brain areas, reduced HIF‐1α expression, protected ...
Sudipta Ray, Mohit Kumar, Divya T. Chemparathy, Prasanta K. Dash, Susmita Sil   +4 more
wiley   +1 more source