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Dentate Gyrus Immaturity in Schizophrenia
The Neuroscientist, 2019Hippocampal abnormalities have been heavily implicated in the pathophysiology of schizophrenia. The dentate gyrus of the hippocampus was shown to manifest an immature molecular profile in schizophrenia subjects, as well as in various animal models of the disorder.
Ayda Tavitian +4 more
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Dentate gyrus neurogenesis and depression [PDF]
, 2007 Major depressive disorder (MDD) is a debilitating and complex psychiatric disorder that involves multiple neural circuits and genetic and non-genetic risk factors. In the quest for elucidating the neurobiological basis of MDD, hippocampal neurogenesis has emerged as a candidate substrate, both for the etiology as well as treatment of MDD.
Michael R. Drew, Amar Sahay, René Hen
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2007
Computational modeling has become an increasingly useful tool for studying complex neuronal circuits such as the dentate gyrus. In order to effectively apply computational techniques and theories to answer pressing biological questions, however, it is necessary to develop detailed, data-driven models. Development of such models is a complicated process,
Vijayalakshmi Santhakumar +2 more
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Computational modeling has become an increasingly useful tool for studying complex neuronal circuits such as the dentate gyrus. In order to effectively apply computational techniques and theories to answer pressing biological questions, however, it is necessary to develop detailed, data-driven models. Development of such models is a complicated process,
Vijayalakshmi Santhakumar +2 more
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Neuropeptide Y in the dentate gyrus
2007Neuropeptide Y (NPY) is contained in at least four types of GABAergic interneurons in the dentate gyrus, many of which also contain somatostatin and give rise to the dense NPY innervation of the dentate outer molecular layer. In humans but not rats, minute amounts of NPY are also normally expressed in dentate granule cells, while seizure activity in ...
William F. Colmers +2 more
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Opioid systems in the dentate gyrus
2007Opiate drugs alter cognitive performance and influence hippocampal excitability, including long-term potentiation (LTP) and seizure activity. The dentate gyrus (DG) contains two major opioid peptides, enkephalins and dynorphins, which have opposing effects on excitability. Enkephalins preferentially bind to delta- and mu-opioid receptors (DORs and MORs)
Carrie T. Drake +2 more
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Norepinephrine and the dentate gyrus
2007Norepinephrine's role in the dentate gyrus is assessed based on a review of what is known about its innervation and receptor patterns and its functional effects at both cellular and behavioral levels. The data support seven hypotheses: (1) Norepinephrine's functional actions are primarily mediated by beta adrenoceptors and include electrophysiological ...
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Neurotrophins in the dentate gyrus
2007Since the discovery of nerve growth factor (NGF) in the 1950s and brain-derived neurotrophic factor (BDNF) in the 1980s, a great deal of evidence has mounted for the roles of neurotrophins (NGF; BDNF; neurotrophin-3, NT-3; and neurotrophin-4/5, NT-4/5) in development, physiology, and pathology.
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