Results 261 to 270 of about 139,984 (307)

Propionic Acidemia: Gray Matter Disease Meets Subcortical Leukodystrophy

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Imaging literature on propionic acidemia (PA) is predominantly concerned with deep gray matter changes. In order to investigate the spectrum and patterns of MRI changes, 45 MRI scans of 13 patients (0.31–33.2 years) were systematically analyzed. Deep and cortical gray matter changes were associated with acute metabolic decompensation. Striatum
Hannah Fels‐Palesandro, Friederike Hörster, Dorothea Haas, Florian Gleich, Sven F. Garbade, Stefan Kölker, Inga Harting   +6 more
wiley   +1 more source

The Suprapyramidal and Infrapyramidal Blades of the Dentate Gyrus Exhibit Different GluN Subunit Content and Dissimilar Frequency-Dependent Synaptic Plasticity In Vivo. [PDF]

Hippocampus
Strauch C, Böge J, Shchyglo O, Dubovyk V, Manahan-Vaughan D.   +4 more
europepmc   +1 more source

Age‐Associated Transcriptomic and Epigenetic Alterations in Mouse Hippocampus

Aging Cell, Volume 24, Issue 11, November 2025.
Single‐nucleus multiome sequencing of hippocampus reveals aging‐dependent changes in gene expression and chromatin accessibility. Chromatin alterations in synaptic genes often occur without corresponding expression changes, suggesting a “susceptible” chromatin state.
Merve Bilgic, Rinka Obata, Vlada‐Iuliana Panfil, Ziying Zhu, Mai Saeki, Yukiko Gotoh, Yusuke Kishi   +6 more
wiley   +1 more source

Study on the Role of Dnmt3a Expression in the Dentate Gyrus of the Hippocampus in Reward Memory. [PDF]

Alpha Psychiatry
Zheng X, Ma R, He E, Peng X, Ma W, Zhang X, Li Y, Li H, Li Y, Gong Z.   +9 more
europepmc   +1 more source

Brain DNA Methylation Atlas of AppNL‐G‐F Alzheimer's Disease Model Mice Across Age and Region Reveals Choline‐Induced Resilience

Aging Cell, Volume 24, Issue 11, November 2025.
Brain DNA methylation drives abnormal gene expression in AppNL‐G‐F mice. Perinatal choline supplementation may promote resilience to synaptic dysfunction through modulation of DNA methylation. ABSTRACT Alzheimer's disease (AD) is the most common type of dementia.
Andre Krunic, Thomas A. Bellio, Benjamin Z. Cohen, Adam Labadorf, Thor D. Stein, Honghuang Lin, Tiffany J. Mellott, Jan K. Blusztajn   +7 more
wiley   +1 more source

Maturational Stage-Dependent Contributions of the Cav3.2 T-Type Calcium Channel to Dentate Gyrus Granule Cell Excitability. [PDF]

eNeuro
Sack AS, Garcia E, Snutch TP.
europepmc   +1 more source

Reviewer #1 (Public review): Cellular and circuit features distinguish dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation

openalex   +1 more source

Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease

Aging Cell, Volume 24, Issue 11, November 2025.
Targeting muscle with Cathepsin B (Ctsb) to treat the AD mouse brain. In this study, an AAV‐vector‐mediated approach, utilized to express Ctsb in muscle, prevented mnemonic and neurogenic deficits and normalized hippocampal, muscle, and plasma proteomic profiles.
Alejandro Pinto, Hazal Haytural, Cássio Morais Loss, Claudia Alvarez, Asude Ertas, Olivia Curtis, Alyssa R. Williams, Grayson Murphy, Kenneth J. Salleng, Sylvia Gografe, Nishant P. Visavadiya, Andy V. Khamoui, Ali Altıntaş, Tal Kafri, Romain Barres, Atul S. Deshmukh, Henriette van Praag   +16 more
wiley   +1 more source

Focal granule cell bilamination of the dentate gyrus-its prevalence across the human age spectrum and review of the literature. [PDF]

J Neuropathol Exp Neurol
Machaalani R, Rodriguez M, Vivekanandarajah A.   +2 more
europepmc   +1 more source

Organ‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming

Aging Cell, Volume 24, Issue 11, November 2025.
Transient in vivo expression of Yamanaka factors (OSKM) enhances regenerative competence and rejuvenation across multiple tissues. We highlight mechanistic links between injury‐induced dedifferentiation and OSKM reprogramming, while emphasizing safety challenges and the need for precise spatiotemporal control to enable clinical translation.
Beom‐Ki Jo, Seung‐Yeon Lee, Hee‐Ji Eom, Jumee Kim, Hyuk‐Jin Cha   +4 more
wiley   +1 more source