Results 261 to 270 of about 117,269 (356)

Towards an Understanding of the Dentate Gyrus Hilus. [PDF]

Hippocampus
Scharfman HE.
europepmc   +1 more source

Effects of elevated glucocorticoid levels on dentate gyrus development

, 2012
Zachary Dale Vallandingham
openalex   +1 more source

The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease

, 2013
Rick Shin, Katsunori Kobayashi, Hideo Hagihara, Jeffrey H. Kogan, Shinichi Miyake, Katsunori Tajinda, Noah M. Walton, Adam K. Gross, Carrie Heusner, Chen Qian, Kouichi Tamura, Tsuyoshi Miyakawa, Mitsuyuki Matsumoto   +12 more
openalex   +2 more sources

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, Volume 13, Issue 2, 9 January 2026.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Recurrent Interneuron Connectivity Does Not Support Synchrony in a Biophysical Dentate Gyrus Model. [PDF]

eNeuro
Müller-Komorowska D, Fujishige T, Fukai T.   +2 more
europepmc   +1 more source

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, Volume 13, Issue 3, 14 January 2026.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice. [PDF]

Nat Commun
Yuan M, Cazala A, Goedeke S, Leibold C, Sauer JF, Bartos M.   +5 more
europepmc   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus. [PDF]

Front Cell Neurosci
Netsyk O, Korol SV, Birnir B, Jin Z.
europepmc   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source