Results 261 to 270 of about 131,553 (328)

Hippocampal Astrocyte Morphology Follows an Unexpected Trajectory With Age in a Transgenic Rodent Model of Tauopathy

open access: yesGlia, Volume 73, Issue 7, Page 1502-1519, July 2025.
Main Points During ageing, the complexity of astrocyte morphology peaks at adulthood then declines. In Tau22 transgenic mice, tau accumulates in astrocytes with age. Tauopathy is associated with simpler initial morphology followed by the appearance of a cluster of complex cells at advanced stage.
Emma Augustin   +20 more
wiley   +1 more source

Loss of NFIA Impairs Adult Hippocampal Neurogenesis

open access: yesHippocampus, Volume 35, Issue 4, July 2025.
ABSTRACT Adult hippocampal neurogenesis (AHN) is the process by which new neurons are continuously generated from neural stem and progenitor cells (NSPCs) in the adult dentate gyrus. AHN plays a pivotal role in cognitive functions, including learning, memory, and mood regulation.
Mi Wang   +4 more
wiley   +1 more source

Lithium enhances long-term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus [PDF]

open access: bronze, 2003
Hyeon Son   +6 more
openalex   +1 more source

Chronic α5‐GABA‐A Receptor Potentiation Promotes Mouse Adult Hippocampal Neurogenesis

open access: yesHippocampus, Volume 35, Issue 4, July 2025.
ABSTRACT Several lines of evidence implicate adult hippocampal neurogenesis (AHN) in cognitive functions, in mood‐ and anxiety‐related behaviors, and in the therapeutic effects of antidepressants. Augmenting α5‐γ‐Aminobutyric acid type A (GABAA) receptor function has shown neurotrophic effects in stress and aged models, but its impact on mouse AHN ...
Thomas D. Prevot   +7 more
wiley   +1 more source

Piperazine Derivatives Attenuate Scopolamine‐Induced Memory Deficits by Modulating Neuroinflammation and Oxidative Stress via the NF‐κB/TNF‐α/COX‐2 Pathway

open access: yesChemistrySelect, Volume 10, Issue 25, July 4, 2025.
Piperazine derivatives 2b, 2f, and 2h reduce neuroinflammation, oxidative stress, and memory impairment by modulating COX‐2, p‐NF‐κB, and TNF‐α pathways, showing promise as lead compounds for neurodegenerative disease drug development. Abstract Oxidative stress‐induced neuro‐inflammatory events are common in neurodegenerative illnesses, addressing ...
Sadaf Fardoos   +8 more
wiley   +1 more source

Enhanced Expression of a Specific Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel (HCN) in Surviving Dentate Gyrus Granule Cells of Human and Experimental Epileptic Hippocampus [PDF]

open access: bronze, 2003
Roland A. Bender   +6 more
openalex   +1 more source

Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.
ABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's disease (AD) and schizophrenia. α7 nAChRs play essential roles in neurotransmission, neuroinflammation and synaptic plasticity, not only in neurons but also in glial cells, where they ...
Janus H. Magnussen
wiley   +1 more source

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