Results 261 to 270 of about 63,053 (291)

An analysis of the dentate gyrus function

Behavioural Brain Research, 2013
In this review article the emphasis will be on the role of the DG (dorsal and ventral) in supporting memory based on the operation of specific processes. Based on the development of computational models of dorsal dentate gyrus (dDG) and behavioral evidence based on dysfunction of dDG, this review will show that the dDG mediates mnemonic processing of ...
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Somatostatin in the dentate gyrus

2007
The neuropeptide somatostatin (SST) is expressed in a discrete population of interneurons in the dentate gyrus. These interneurons have their soma in the hilus and project to the outer molecular layer onto dendrites of dentate granule cells, adjacent to perforant path input.
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Electrophysiology of dentate gyrus granule cells

Journal of Neurophysiology, 1984
The orthodromic synaptic responses, membrane properties, and responses of dentate gyrus granule cells (DGCs) to several convulsant agents were studied in the in vitro hippocampal slice preparation. Orthodromic stimulation via the perforant pathway (PP) evoked excitatory-inhibitory postsynaptic potentials (EPSP-IPSP) sequences in 27 of 34 DGCs studied.
R. A. Fricke, David A. Prince
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On the number of neurons in the dentate gyrus of the rat

Brain Research, 1985
We have estimated the number of dentate granule cells in Sprague-Dawley and Wistar rats at 1, 4 and 12 months of age. In Sprague-Dawley rats the number of granule cells is relatively constant throughout this period at about 1 million. In Wistar rats, on the other hand, there is a progressive increase in the number from about 700,000 at 1 month to 1 ...
W. Maxwell Cowan, Barbara D. Boss, Gary M. Peterson   +2 more
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Adult neurogenesis in the mammalian dentate gyrus

Anatomia, Histologia, Embryologia, 2019
AbstractEarlier observations in neuroscience suggested that no new neurons form in the mature central nervous system. Evidence now indicates that new neurons do form in the adult mammalian brain. Two regions of the mature mammalian brain generate new neurons: (a) the border of the lateral ventricles of the brain (subventricular zone) and (b) the ...
Louise C. Abbott, Fikru Nigussie
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The dentate gyrus in Alzheimer's disease

2007
As part of the hippocampus, the dentate gyrus is considered to play a crucial role in associative memory. The reviewed data suggest that the dentate gyrus withstands the formation of plaques, tangles and neuronal death until late stages of Alzheimer's disease (AD).
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Adult Neurogenesis in the Dentate Gyrus

2014
Adult neurogenesis is a unique form of structural plasticity in the brain. Localized specifically to the dentate gyrus region, new granule cells continue to integrate into the functioning circuit throughout life. Over the last 2 decades, neurogenesis has gone from a controversial side note within the hippocampal community to a process believed to ...
Wei Deng, Fred H. Gage, James B. Aimone
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An analysis of dentate gyrus function (an update)

Behavioural Brain Research, 2018
In this review there will be a description of the dentate gyrus (DG) neural circuitry that mediates the operation of a variety of mnemonic processes associated with dorsal and ventral DG function in rats. Dysfunction of the dorsal DG can be shown to mediate mnemonic processing of spatially based information including a) the operation of conjunctive ...
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Role of corticosteroid hormones in the dentate gyrus

2007
Dentate granule cells are enriched with receptors for the stress hormone corticosterone, i.e., the high-affinity mineralocorticoid receptor (MR), which is already extensively occupied with low levels of the hormone, and the glucocorticoid receptor (GR), which is particularly activated after stress.
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Genetic regulation of dentate gyrus morphogenesis

2007
The dentate gyrus is one of the small number of forebrain areas that have continued adult neurogenesis. During development the dentate gyrus acquires the capacity for neurogenesis by generating a new neurogenic stem cell niche at the border between the hilus and dentate granule cell layer. This is in distinction to the other prominent zone of continued
Samuel J. Pleasure, Guangnan Li
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