Results 261 to 270 of about 131,553 (328)
Main Points During ageing, the complexity of astrocyte morphology peaks at adulthood then declines. In Tau22 transgenic mice, tau accumulates in astrocytes with age. Tauopathy is associated with simpler initial morphology followed by the appearance of a cluster of complex cells at advanced stage.
Emma Augustin+20 more
wiley +1 more source
Perisynaptic Localization of δ Subunit-Containing GABAAReceptors and Their Activation by GABA Spillover in the Mouse Dentate Gyrus [PDF]
Weizheng Wei+4 more
openalex +1 more source
Loss of NFIA Impairs Adult Hippocampal Neurogenesis
ABSTRACT Adult hippocampal neurogenesis (AHN) is the process by which new neurons are continuously generated from neural stem and progenitor cells (NSPCs) in the adult dentate gyrus. AHN plays a pivotal role in cognitive functions, including learning, memory, and mood regulation.
Mi Wang+4 more
wiley +1 more source
Lithium enhances long-term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus [PDF]
Hyeon Son+6 more
openalex +1 more source
Chronic α5‐GABA‐A Receptor Potentiation Promotes Mouse Adult Hippocampal Neurogenesis
ABSTRACT Several lines of evidence implicate adult hippocampal neurogenesis (AHN) in cognitive functions, in mood‐ and anxiety‐related behaviors, and in the therapeutic effects of antidepressants. Augmenting α5‐γ‐Aminobutyric acid type A (GABAA) receptor function has shown neurotrophic effects in stress and aged models, but its impact on mouse AHN ...
Thomas D. Prevot+7 more
wiley +1 more source
Piperazine derivatives 2b, 2f, and 2h reduce neuroinflammation, oxidative stress, and memory impairment by modulating COX‐2, p‐NF‐κB, and TNF‐α pathways, showing promise as lead compounds for neurodegenerative disease drug development. Abstract Oxidative stress‐induced neuro‐inflammatory events are common in neurodegenerative illnesses, addressing ...
Sadaf Fardoos+8 more
wiley +1 more source
Enhanced Expression of a Specific Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel (HCN) in Surviving Dentate Gyrus Granule Cells of Human and Experimental Epileptic Hippocampus [PDF]
Roland A. Bender+6 more
openalex +1 more source
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
H. Cameron, R. McKay
semanticscholar +1 more source
ABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's disease (AD) and schizophrenia. α7 nAChRs play essential roles in neurotransmission, neuroinflammation and synaptic plasticity, not only in neurons but also in glial cells, where they ...
Janus H. Magnussen
wiley +1 more source