Results 51 to 60 of about 3,794 (158)

Heroic Saves in Endodontics: Management of Advanced External Cervical Resorption With Intentional Replantation: A Review and Report of Two Cases

Case Reports in Dentistry, Volume 2026, Issue 1, 2026.
External cervical resorption (ECR) is a complex and aggressive form of root resorption that poses significant challenges in clinical management. This case report describes two cases of advanced ECR treated with intentional replantation (IR), highlighting its efficacy as a viable treatment option for preservation of compromised teeth.
Mohsen Aminsobhani, Pegah Sarraf, Mehrfam Khoshkhounejad, Maryam Babaahmadi, Tommaso Lombardi   +4 more
wiley   +1 more source

Histone Acetylation as a Regenerative Target in the Dentine-Pulp Complex

Frontiers in Genetics, 2020
If dental caries (or tooth decay) progresses without intervention, the infection will advance through the dentine leading to severe pulpal inflammation (irreversible pulpitis) and pulp death.
Yukako Yamauchi, Paul Roy Cooper, Emi Shimizu, Yoshifumi Kobayashi, Anthony J. Smith, Henry Fergus Duncan   +5 more
doaj   +1 more source

Bioactivity and Regenerative Potential of Cannabidiol in Human Dental Pulp Stem Cells: A Scoping Review of In Vitro Studies

The Scientific World Journal, Volume 2026, Issue 1, 2026.
Introduction Cannabidiol (CBD), a nonpsychoactive compound derived from Cannabis sativa, has shown potential to influence cellular processes that are important for dental tissue repair. The aim of this scoping review was to map in vitro studies evaluating the influence of CBD on the osteogenic/odontogenic differentiation of human dental pulp stem cells
Lorena Gomes Guimarães, Wesley Viana de Sousa, Silmara de Andrade Silva, Christianne Velozo, Carolina Viana Vasco Lyra, Larissa Sousa Rangel, Maria Alice Lopes Pereira, Diana Albuquerque, Venkatesh Srinivasan   +8 more
wiley   +1 more source

The Patterning Cascade Model and Human Mandibular Premolar Variation

American Journal of Biological Anthropology, Volume 188, Issue 4, December 2025.
ABSTRACT Objectives The patterning cascade model (PCM) provides a predictive framework for examining crown variation and posits that tooth size and enamel knot spacing, along with surrounding inhibitory fields, strongly influence crown morphology. The aim of this study is to determine if mandibular premolar variation aligns with predictions derived ...
Molly Militello, Dori E. Kenessey, Christopher M. Stojanowski, Kathleen S. Paul   +3 more
wiley   +1 more source

PFKFB3‐Inhibitor 3PO‐Mediated Glycolytic Reprogramming Promotes Inflammatory Dental Pulp Repair: An In Vitro and In Vivo Study

International Endodontic Journal, Volume 58, Issue 12, Page 1872-1889, December 2025.
ABSTRACT Aim This study explores the role of PFKFB3 in pulpitis and its potential as a therapeutic target by modulating glycolytic reprogramming in dental pulp stem cells (DPSCs). Pulpitis, a common inflammatory disease, causes long‐term damage to dental structures.
Yanqiang Zhao, Yuqing Peng, Dan Wang, Lixin Zhang, Yijia Qiu, Jingyi Cui, Fei Xie, Ningxin Zhu, Man Qin, Yuanyuan Wang   +9 more
wiley   +1 more source

Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao, Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Xu Chen, Zihao Zhou, Li Cui   +7 more
wiley   +1 more source

Barriers to oral health care service utilization in Awo-Gareji community, Ankpa Local Government Area, Kogi State, Nigeria

Orapuh Journal
Introduction Lack of access to oral health care can result in delayed diagnosis, untreated oral diseases, compromised health status, and, occasionally, death.
Dr. Johnson J. Omale, B. M. Hussain, M. C. Nweze, S. A. Ani, A. N. Ohadoma   +4 more
doaj   +1 more source

LPS‐Induced Mitochondrial Damage via SLC41A1‐Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Lipopolysaccharide induces upregulation of the magnesium (Mg2+) efflux transporter solute carrier family 41 member 1 in dental stem cells, leading to a decrease in intracellular Mg2+ concentration and promoting the binding of oligomycin sensitivity‐conferring protein and cyclophilinD.
Yuan Liu, Chenyu Song, Liyuan Zhang, Xue Han, Chaoyuan Li, Yanhong Yan, Ludan Xing, Mengting Si, Bo Yang, Lingyuan Cheng, Akimi Muramatsu, Beizhan Jiang   +11 more
wiley   +1 more source

Profiles of Wnt pathway gene expression during tooth morphogenesis

Frontiers in Physiology
Mouse and human genetic studies indicate key roles of the Wnt10a ligand in odontogenesis. Previous studies have identified effectors and regulators of the Wnt signaling pathway actively expressed during key stages of tooth morphogenesis.
Resmi Raju, Jeremie Oliver Piña, Jeremie Oliver Piña, Daniela M. Roth, Daniela M. Roth, Parna Chattaraj, Fahad K. Kidwai, Fabio R. Faucz, James Iben, Gus Fridell, Ryan K. Dale, Rena N. D’Souza   +11 more
doaj   +1 more source

Clinical and Molecular Heterogeneity Underlying Monogenic Causes of Pediatric Diabetes Associated to Brain Developmental Disorders

Clinical Genetics, Volume 108, Issue 5, Page 495-510, November 2025.
A growing number of genetic variants linking non‐autoimmune diabetes to NDDs across different ages offer key insights about a common background of these phenotypes. These findings call for multidisciplinary approaches to care that integrate metabolic and neurological management in affected children.
Gabriele Di Pasquale, Camilla Valsecchi, Giulia Marie Smylie, Vincenzo Salpietro, Gian Vincenzo Zuccotti, Maurizio Delvecchio, Chiara Mameli   +6 more
wiley   +1 more source