Results 61 to 70 of about 8,702 (246)

Regenerative Endodontic Treatment in Dentinogenesis Imperfecta-Induced Apical Periodontitis

Case Reports in Dentistry
Pulp involvement of immature permanent teeth with dentinogenesis imperfecta is challenging and could lead to extraction. A case of dentinogenesis imperfecta-induced periapical periodontitis of an immature permanent tooth was treated with regenerative ...
Ying Liao, Ting Pan, Xianghui Xing
doaj   +1 more source

Epidemiological and Clinical Features of Regional Odontodysplasia in South Korean Pediatric Patients: A Multicenter Case Series Study

International Journal of Paediatric Dentistry, Volume 36, Issue 1, Page 140-152, January 2026.
ABSTRACT Background Regional odontodysplasia (RO) is a rare developmental dental anomaly with unknown prevalence. Current knowledge is largely limited to individual case reports. Aim This study aims to present epidemiological data, clinical features, and radiographic characteristics of pediatric and adolescent patients with RO in South Korea. Design In
So Dam Lee, Je Seon Song, Hyo Seoul Lee, Hyuntae Kim, Yeonmi Yang, Ko Eun Lee   +5 more
wiley   +1 more source

Growth factor liberation and DPSCs response following dentine conditioning [PDF]

, 2016
Liberation of the sequestrated bioactive molecules from dentine by the action of applied dental materials has been proposed as an important mechanism in inducing a dentinogenic response in teeth with viable pulps.
Gleeson, Hannah, Lynch, Christopher, Sadaghiani, Leili, Sloan, Alastair, Waddington, Rachel, Youde, Sarah   +5 more
core   +1 more source

Promoting dentinogenesis of DPSCs through inhibiting microRNA-218 by using magnetic nanocarrier delivery

Journal of the Formosan Medical Association, 2019
Purpose: The purposes of this study are to explore the roles of microRNA-218 (miR-218) delivered by a newly designed magnetic nanocarrier: GCC-Fe3O4 (GCC-Fe) in dentinogenesis potentials of human dental pulp stem cells (DPSCs).
Karen Chang, Rung-Shu Chen, Fu-Hsiung Chang, Min-Huey Chen   +3 more
doaj   +1 more source

The Patterning Cascade Model and Human Mandibular Premolar Variation

American Journal of Biological Anthropology, Volume 188, Issue 4, December 2025.
ABSTRACT Objectives The patterning cascade model (PCM) provides a predictive framework for examining crown variation and posits that tooth size and enamel knot spacing, along with surrounding inhibitory fields, strongly influence crown morphology. The aim of this study is to determine if mandibular premolar variation aligns with predictions derived ...
Molly Militello, Dori E. Kenessey, Christopher M. Stojanowski, Kathleen S. Paul   +3 more
wiley   +1 more source

Helical mutations in type I collagen that affect the processing of the amino-propeptide result in an Osteogenesis Imperfecta/Ehlers-Danlos Syndrome overlap syndrome [PDF]

, 2013
Background: Whereas mutations affecting the helical domain of type I procollagen classically cause Osteogenesis Imperfecta (OI), helical mutations near the amino (N)-proteinase cleavage site have been suggested to result in a mixed OI/Ehlers-Danlos ...
De Paepe, Anne, Goemans, Nathalie, Gyftodimou, Yolanda, Holmberg, Eva, Lopez-Gonzalez, Vanesa, Malfait, Fransiska, Mortier, Geert, Nampoothiri, Sheela, Petersen, Michael Bjorn, Symoens, Sofie   +9 more
core   +2 more sources

PFKFB3‐Inhibitor 3PO‐Mediated Glycolytic Reprogramming Promotes Inflammatory Dental Pulp Repair: An In Vitro and In Vivo Study

International Endodontic Journal, Volume 58, Issue 12, Page 1872-1889, December 2025.
ABSTRACT Aim This study explores the role of PFKFB3 in pulpitis and its potential as a therapeutic target by modulating glycolytic reprogramming in dental pulp stem cells (DPSCs). Pulpitis, a common inflammatory disease, causes long‐term damage to dental structures.
Yanqiang Zhao, Yuqing Peng, Dan Wang, Lixin Zhang, Yijia Qiu, Jingyi Cui, Fei Xie, Ningxin Zhu, Man Qin, Yuanyuan Wang   +9 more
wiley   +1 more source

Noggin inhibition of mouse dentinogenesis

Journal of Oral Biosciences, 2020
The Bone Morphogenetic Proteins (BMPs) direct tooth development and still express in the adult tooth. We hypothesized that inhibition of BMP function would therefore disrupt dentinogenesis by differentiated odontoblasts.We generated mice overexpressing the BMP-inhibitory protein Noggin in differentiated odontoblasts and osteocytes under control of a ...
Priyam, Jani, Hua, Zhang, M Douglas, Benson, Chunlin, Qin   +3 more
openaire   +3 more sources

Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao, Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Xu Chen, Zihao Zhou, Li Cui   +7 more
wiley   +1 more source

LPS‐Induced Mitochondrial Damage via SLC41A1‐Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Lipopolysaccharide induces upregulation of the magnesium (Mg2+) efflux transporter solute carrier family 41 member 1 in dental stem cells, leading to a decrease in intracellular Mg2+ concentration and promoting the binding of oligomycin sensitivity‐conferring protein and cyclophilinD.
Yuan Liu, Chenyu Song, Liyuan Zhang, Xue Han, Chaoyuan Li, Yanhong Yan, Ludan Xing, Mengting Si, Bo Yang, Lingyuan Cheng, Akimi Muramatsu, Beizhan Jiang   +11 more
wiley   +1 more source