Results 71 to 80 of about 24,920 (225)

Preliminary study on the effect of Munronia pinnata (Wall) Theob. (Meliaceae) aqueous extract on functional change in endothelial cells infected by dengue virus

Scientific African, 2023
Infection of endothelial cells (ECs) and their dysfunction has been implicated in the immunopathogenesis leading to severity in dengue virus (DENV) disease and rationalize the therapeutic targeting of the endothelium. Munronia pinnata is a rare medicinal
Pierre Celestin Munezero, Shiroma Handunnetti, Narmada Fernando, Loshini Ranaweera, Swarna Damayanthi Hapuarachchi, Boniface Makori Nyamweya, Joseph Ndacyayisenga   +6 more
doaj   +1 more source

Miscarriage following dengue virus 3 infection in the first six weeks of pregnancy of a dengue virus-naive traveller returning from Bali to Italy, April 2016 [PDF]

, 2016
We report miscarriage following dengue virus (DENV)-3 infection in a pregnant woman returning from Bali to Italy in April 2016. On her arrival, the woman had fever, rash, asthenia and headache.
Baldanti, Fausto, Campanini, G., Castelli, F., Cristini, G., Percivalle, E., Rovida, F., Sarasini, A., Tomasoni, L. R., Zavattoni, M.   +8 more
core   +1 more source

Differential Infectivity of Human Neural Cell Lines by a Dengue Virus Serotype-3 Genotype-III with a Distinct Nonstructural Protein 2A (NS2A) Amino Acid Substitution Isolated from the Cerebrospinal Fluid of a Dengue Encephalitis Patient

Canadian Journal of Infectious Diseases and Medical Microbiology, 2023
Dengue encephalitis is considered as a severe but unusual clinical presentation of dengue infection. Limited molecular information is available on the neurotropism of dengue virus (DENV), highlighting the need for further research.
Minh Huong Phu Ly, Co Thach Nguyen, Thanh Vu Nguyen, Thanh Thi Ngan Nguyen, Takeshi Nabeshima, Ferdinard Adungo, Yuki Takamatsu, Nguyen Tien Huy, Thi Quynh Mai Le, Kouichi Morita, Futoshi Hasebe, Meng Ling Moi   +11 more
doaj   +1 more source

Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protection [PDF]

, 2013
Although prior studies have characterized the neutralizing activities of monoclonal antibodies (MAbs) against dengue virus (DENV) serotypes 1, 2, and 3 (DENV-1, DENV-2, and DENV-3), few reports have assessed the activity of MAbs against DENV-4.
Austin, S. Kyle, Brien, James D, Diamond, Michael S, Doranz, Benjamin J, Fremont, Daved H, Johnson, Syd, Kahle, Kristen, Pierson, Theodore C, Shrestha, Bimmi, Sukupolvi-Petty, Soila, Swayne, Sherri   +10 more
core   +2 more sources

On the Dynamics of Dengue Virus type 2 with Residence Times and Vertical Transmission

, 2016
A two-patch mathematical model of Dengue virus type 2 (DENV-2) that accounts for vectors' vertical transmission and between patches human dispersal is introduced. Dispersal is modeled via a Lagrangian approach.
Bichara, Derdei, Castillo-Chavez, Carlos, Holechek, Susan A., Murillo, Anarina L., Velazquez-Castro, Jorge   +4 more
core   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Phylogenetic analyses of DENV-3 isolated from field-caught mosquitoes in Thailand

Virus Research, 2018
Dengue virus serotype 3 (DENV-3) can cause all forms of dengue diseases and is a predominant serotype in many countries. This serotype is classified into five genotypes: I-V. Genotypes I-III have widely spread throughout the world, whereas genotypes IV and V are rare. Despite the impact on the spread of dengue diseases, only a few studies have reported
Thikhumporn, Sittivicharpinyo, Passorn, Wonnapinij, Wunrada, Surat   +2 more
openaire   +2 more sources

First report of multiple lineages of dengue viruses type 1 in Rio de Janeiro, Brazil [PDF]

, 2011
Background In Brazil dengue has been a major public health problem since DENV-1 introduction and spread in 1986. After a low or silent co-circulation, DENV-1 re-emerged in 2009 causing a major epidemic in the country in 2010 and 2011.
Flavia B dos Santos, Fernanda B Nogueira, Márcia G Castro, Priscila CG Nunes, Ana Maria B de Filippis, Nieli RC Faria, Jaqueline BS Simões, Simone A Sampaio, Clarice R Santos, Rita Maria R Nogueira   +9 more
core   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Identification of Continuous Human B-Cell Epitopes in the Envelope Glycoprotein of Dengue Virus Type 3 (DENV-3)

PLoS ONE, 2009
Dengue virus infection is a growing global public health concern in tropical and subtropical regions of the world. Dengue vaccine development has been hampered by concerns that cross-reactive immunological memory elicited by a candidate vaccine could increase the risk of development of more severe clinical forms.
Andréa N. M. Rangel da Silva, Eduardo J. M. Nascimento, Marli Tenório Cordeiro, Laura H. V. G. Gil, Frederico G. C. Abath, Sílvia Maria Lucena Montenegro, Ernesto T. A. Marques   +6 more
openalex   +5 more sources