Results 81 to 90 of about 24,920 (225)

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Predominance of DENV-3 among patients in Ouagadougou, Burkina Faso

Journal of Vector Borne Diseases
Background & objectives: Dengue is an emerging vector-borne viral disease in tropical and subtropical areas such as Burkina Faso that experienced dengue outbreak in, 2013, 2016, 2017 and more recently in 2023. This study aimed to determine the seroprevalence and dengue serotype in suspected patients in Ouagadougou, Burkina ...
Abdoul Karim Ouattara, Shoukrat Ohuwa Toyin Bello, Alphonsine Ouédraogo, Lassina Traoré, Florencia Wendkuuni Djigma, Jacques Simporé   +5 more
openaire   +3 more sources

Exploring the genetic diversity of the 3′ untranslated region (UTR) of Dengue virus

Virology Journal
Background Dengue virus (DENV), with its four antigenically distinct serotypes, is the etiological agent of dengue fever, which is endemic in tropical and subtropical regions but has recently spread to previously non-endemic areas such as Europe.
Alessandra Lo Presti, Arnold Knijn, Enrico Palermo, Alessandra D’Auria, Miriana Quaranta, Stefano Pascarella, Federica Frasca, Carolina Scagnolari   +7 more
doaj   +1 more source

Analisis Struktur Protein Selubung Virus Dengue Serotipe 3 Pada Genotipe Yang Sama Dengan Clade Berbeda [PDF]

, 2015
Dengue viruses (DENV) consist of 4 serotypes and each of serotype is divided in several genotypes based on the envelope gene. To find the different in protein structure of DENV-3 circulated in Surabaya, we conduct analysis of two sequences of DENV-3 ...
Herman, R. (Reni), Putri, D. H. (Dwi)
core  

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
This review focuses on the 10–23 DNAzyme in diagnostics, spanning unregulated and regulated target‐recognition modes, and their functionalization across colorimetric, fluorescent, electrochemical, electrochemiluminescent, and intracellular biosensing strategies.
Connor Nurmi, Jake Brill, Sanne Roumans, Amal Mathai, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006. [PDF]

PLoS Neglected Tropical Diseases, 2010
It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand.Prospective studies were conducted ...
Jessica R Fried, Robert V Gibbons, Siripen Kalayanarooj, Stephen J Thomas, Anon Srikiatkhachorn, In-Kyu Yoon, Richard G Jarman, Sharone Green, Alan L Rothman, Derek A T Cummings   +9 more
doaj   +1 more source

Natural Products as Source of Potential Dengue Antivirals [PDF]

, 2014
Dengue is a neglected disease responsible for 22,000 deaths each year in areas where it is endemic. To date, there is no clinically approved dengue vaccine or antiviral for human beings, even though there have been great efforts to accomplish these goals.
Adalberto da Silva, Allard, Ana Oliveira, André de Oliveira, Cynthia da Silva, Dos Santos, Gubler, Kraan, Laurent, Li, Milene da Silva, Normile, Paint, Pujol, Rahman, Róbson Teixeira, Sérgio de Paula, Tassniyom, Wagner Pereira, Zandi, Zandi, Zandi   +21 more
core   +4 more sources

Mitigating Cultural Constraints on Environmental Performance With Women on Boards During Crises

Business Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT Existing management literature has acknowledged the intricate interplay between board gender diversity (BGD), national culture, and environmental performance (EP). However, the COVID‐19 pandemic offers an unprecedented context to reexamine these relationships.
Aranthy Sabaratnam, Vikkram Singh, Sui Sui, Anjali Chaudhry   +3 more
wiley   +1 more source