Results 191 to 200 of about 25,107 (224)

Transcriptional and posttranscriptional regulation of deoxycytidine kinase

2021
Η κινάση της δεοξυτιδίνης καταλύει τη φωσφορυλίωση της 2-δεοξυκυτιδίνης στην μονοφωσφορική της μορφή. Έχει βρεθεί να φωσφορυλιώνει μεγάλη ποικιλία υποστρωμάτων όπως δεοξυπουρίνες και δεοξυπυριμιδίνες. Η κυνάση αυτή είναι επίσης υπεύθυνη για την αρχική ενεργοποίηση ενός μεγάλου αριθμού κλινικά σημαντικών αναλόγων των νουκλεοσιδίων που χρησιμοποιούνται ...
openaire   +2 more sources

Deoxycytidine Kinase is Reversibly Phosphorylated in Normal Human Lymphocytes

Nucleosides, Nucleotides and Nucleic Acids, 2006
The activity of deoxycytidine kinase (dCK) has been shown to be enhanced upon genotoxic stress in human lymphocytes, and reversible phosphorylation of the enzyme has been implicated in the activation process. Here, we provide compelling evidence that dCK is a cytosolic phosphoprotein.
G, Keszler, T, Spasokoukotskaja, M, Sasvári-Székely, S, Eriksson, M, Staub   +4 more
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Nutritional and Hormonal Regulation of Liver Deoxycytidine Kinase Activity

Biochemical and Biophysical Research Communications, 1993
Administration of CdR (50 mg/100 g every 12 h) elevated hepatic CdR kinase (EC 2.7.1.74) activity in normal or adrenalectomized rats over the control values 2- to 2.7-fold. Actinomycin (5 micrograms/100 g) or cycloheximide (50 micrograms/100 g) blocked the increase in enzyme activity.
R L, Singhal, M, Abonyi, G, Weber
openaire   +2 more sources

Quantitative immunoassay of human deoxycytidine kinase in malignant cells

Analytical Biochemistry, 1992
Deoxycytidine kinase (dCK) is necessary for the activity of several nucleosides used for the chemotherapy of cancer and AIDS. However, the measurement of dCK catalytic activity in crude cell extracts may be imprecise, due to the presence of phosphatases and nucleotidases that degrade the enzyme products.
H, Kawasaki, C J, Carrera, D A, Carson
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Role of Deoxycytidine Kinase (dCK), Thymidine Kinase 2 (TK2), and Deoxycytidine Deaminase (dCDA) in the Antitumor Activity of Gemcitabine (dFdC)

1998
Deoxycytidine kinase (dCK) and deaminase (dCDA) are as activating and inactivating enzymes, respectively, in the metabolism of several chemotherapeutically important deoxynucleoside analogues [1]. 2′2′-Difluorodeoxycytidine (dFdC; gemcitabine) has considerable antitumor activity against solid tumors, such as against the chemoresistant non-small cell ...
J R, Kroep, C J, van Moorsel, G, Veerman, D A, Voorn, R M, Schultz, J F, Worzalla, L R, Tanzer, R L, Merriman, H M, Pinedo, G J, Peters   +9 more
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Phosphorylation of 5-Halogenated Deoxycytidine Analogues by Deoxycytidine Kinase

Molecular Pharmacology, 1973
G M, Cooper, S, Greer
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Deoxycytidine kinase

1997
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Kinetics of phosphorylation of 5-aza-2′-deoxycytidine by deoxycytidine kinase

Biochemical Pharmacology, 1979
L. Richard, null Momparler, David Derse
openaire   +2 more sources

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly