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Long-term safety and efficacy of deoxycytidine/deoxythymidine in treatment of POLG-related disorders [PDF]
NeurotherapeuticsWe evaluated the safety and efficacy of enteral deoxycytidine/deoxythymidine combination therapy in treatment of POLG-related disorders, genetic mitochondrial diseases characterized by progressive neurological degeneration.
Anthony C.T. Cheung +8 more
doaj +2 more sources
Replacement of 2′-Deoxycytidine by 2′-Deoxycytidine Analogues in the E. coli Genome [PDF]
Journal of the American Chemical Society, 2016 Several modified bases have been observed in the genomic DNA of bacteriophages, prokaryotes, and eukaryotes that play a role in restriction systems and/or epigenetic regulation. In our efforts to understand the consequences of replacing a large fraction of a canonical nucleoside with a modified nucleoside, we previously replaced around 75% of thymidine
Angad P, Mehta +5 more
openaire +3 more sources
Global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2'-deoxycytidine results in increased tumorigenicity. [PDF]
PLoS ONE, 2009 Abnormal patterns of DNA methylation are observed in several types of human cancer. While localized DNA methylation of CpG islands has been associated with gene silencing, the effect that genome-wide loss of methylation has on tumorigenesis is not ...
Christopher A Hamm +10 more
doaj +2 more sources
N4-Benzoyl-N3-benzyl-2′-deoxycytidine
MolbankWe have recently demonstrated that the pendant tert-butyldiphenylsilyl (TBDPS) groups in the short oligonucleotides TBDPS-5′-CG-3′-3′-GC-5′-TBDPS and TBDPS-5′-CGG-3′-3′-GGC-5′-TBDPS promoted the formation of new lipophilic and stable tetramolecular G ...
Andrea Patrizia Falanga +2 more
doaj +2 more sources
Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutant [PDF]
Computational and Structural Biotechnology Journal5-Hydroxymethyl-2′-deoxycytidine (5hmdC) is an important epigenetic marker involved in gene regulation and DNA demethylation. It has potential use as a biomarker for cancer and other diseases due to its significant depletion in various cancers and ...
Hanife Sahin +7 more
doaj +2 more sources
Cytosolic CTP Production Limits the Establishment of Photosynthesis in Arabidopsis
Frontiers in Plant Science, 2021 CTP synthases (CTPS) comprise a protein family of the five members CTPS1-CTPS5 in Arabidopsis, all located in the cytosol. Specifically, downregulation of CTPS2 by amiRNA technology results in plants with defects in chlorophyll accumulation and ...
Leo Bellin +7 more
doaj +1 more source
Activity of combined gemcitabine therapy on treatment of planocellular carcinoma: A pilot study [PDF]
Archive of Oncology, 2004 BACKGROUND: Drug-orientated, pilot study was conducted to estimate the activity of gemcitabine on treatment of head and neck and lung planocellular carcinoma in combination with either radiotherapy or chemotherapy.
Šćepanović Danijela S. +2 more
doaj +1 more source
Pathogens, 2023 Background: Chronic hepatitis B virus (HBV) infection is a common chronic liver disease that is closely associated with increased morbidity and mortality. Circulating cell-free DNA (cf-DNA) and global DNA methylation, expressed as circulating levels of 5-
Nikolaos D. Karakousis +7 more
doaj +1 more source
Neural Regeneration Research, 2023 Cerebral ischemia/reperfusion injury impairs learning and memory in patients. Studies have shown that synaptic function is involved in the formation and development of memory, and that DNA methylation plays a key role in the regulation of learning and ...
Guang Shi +3 more
doaj +1 more source
Structure-Function Relationship of Human deoxycytidine Kinase.
, 2010 Structure-Function Relationship of Human deoxycytidine ...
Saugata. Hazra (7957007)
core +6 more sources