DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer
Technology in Cancer Research & Treatment, 2020 Background: The biological function of deoxycytidine kinase in tumor is not yet clear, and there are a few studies relating to the correlation of deoxycytidine kinase gene with the occurrence and development of liver cancer.
Shu Fang Hu MM +5 more
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Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions. [PDF]
PLoS Genetics, 2012 5-Aza-2'-deoxycytidine, approved by the FDA for the treatment of myelodysplastic syndrome (MDS), is incorporated into the DNA of dividing cells where it specifically inhibits DNA methylation by forming covalent complexes with the DNA methyltransferases ...
Xiaojing Yang +5 more
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Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models
Experimental Hematology & Oncology, 2020 Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor response to chemo- and (modest-dose conventionally fractionated) radio-therapy. Emerging evidence suggests that pancreatic stellate cells (PSCs) secrete deoxycytidine, which confers resistance
Pei Pei Che +6 more
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PLoS ONE, 2015 BackgroundReplication-independent active/enzymatic demethylation may be an important process in the functioning of somatic cells. The most plausible mechanisms of active 5-methylcytosine demethylation, leading to activation of previously silenced genes ...
Daniel Gackowski +4 more
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TMSOTf assisted synthesis of 2'-deoxy-2'-[18F]fluoro-β-D-arabinofuranosylcytosine ([18F]FAC). [PDF]
PLoS ONE, 2018 [18F]FAC (2'-deoxy-2'-[18F]fluoro-β-D-arabinofuranosylcytosine, 1) is a versatile probe for imaging deoxycytidine kinase (dCK) expression levels in vivo.
Kishore K Gangangari +3 more
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The Intracellular Localization of Deoxycytidine Kinase [PDF]
Journal of Biological Chemistry, 1998 Deoxycytidine kinase (dCK) catalyzes the rate-limiting step of the deoxynucleoside salvage pathway in mammalian cells and plays a key role in the activation of several pharmacologically important nucleoside analogs. Using a highly specific polyclonal antibody raised against a C-terminal peptide of the human dCK, we analyzed its subcellular localization
P, Hatzis +5 more
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Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA. [PDF]
PLoS ONE, 2013 Epigenetic regulations play important roles in plant development and adaptation to environmental stress. Recent studies from mammalian systems have demonstrated the involvement of ten-eleven translocation (Tet) family of dioxygenases in the generation of
Shuo Liu +5 more
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5-Aza-2′-Deoxycytidine Regulates White Adipocyte Browning by Modulating miRNA-133a/Prdm16
Metabolites, 2022 The conversion of white adipocytes into brown adipocytes improves their thermogenesis and promotes energy consumption. Epigenetic modifications affect related genes and interfere with energy metabolism, and these are the basis of new ideas for obesity ...
Jia Liang +7 more
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Research progress of dCTP pyrophosphatase 1 regulating nucleotide metabolism and phenotype of tumor cells [PDF]
Jichu yixue yu linchuang, 2021 Deoxycytidine triphosphate pyrophosphatase 1(dCTP pyrophosphatase 1, DCTPP1) is a newly discovered pyrophosphatase targeting deoxycytidine triphosphate (dCTP).
LI Jing, ZHANG Mei-gui, BAI Zhong-tian
doaj
Replacement of 2′-Deoxycytidine by 2′-Deoxycytidine Analogues in the E. coli Genome [PDF]
Journal of the American Chemical Society, 2016 Several modified bases have been observed in the genomic DNA of bacteriophages, prokaryotes, and eukaryotes that play a role in restriction systems and/or epigenetic regulation. In our efforts to understand the consequences of replacing a large fraction of a canonical nucleoside with a modified nucleoside, we previously replaced around 75% of thymidine
Angad P, Mehta +5 more
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