Results 1 to 10 of about 507,870 (221)

Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency [PDF]

Annals of Neurology, 2017
ObjectiveThymidine kinase 2 (TK2), a critical enzyme in the mitochondrial pyrimidine salvage pathway, is essential for mitochondrial DNA (mtDNA) maintenance. Mutations in the nuclear gene, TK2, cause TK2 deficiency, which manifests predominantly in children as myopathy with mtDNA depletion.
Lopez-Gomez C., Levy R. J., Sanchez-Quintero M. J., Juanola-Falgarona M., Barca E., Garcia-Diaz B., Tadesse S., Garone C., Hirano M.   +8 more
core   +11 more sources

The Novel Phospholipid Mimetic KPC34 Is Highly Active Against Acute Myeloid Leukemia with Activated Protein Kinase C

Translational Oncology, 2020
Acute myeloid leukemia (AML) is an aggressive malignancy with poor outcomes. Nucleoside analogs are subject to resistance mechanisms including downregulation of equilibrative nucleoside transporter (ENT1) and deoxycytidine kinase (dCK).
Peter M. Alexander, Gregory L. Kucera, Kristin M. Pladna, Timothy S. Pardee   +3 more
doaj   +1 more source

Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer

Advanced Science, 2021
Because there is no effective treatment for late‐stage prostate cancer (PCa) at this moment, identifying novel targets for therapy of advanced PCa is urgently needed.
Zhuangzhuang Zhang, Lijun Cheng, Qiongsi Zhang, Yifan Kong, Daheng He, Kunyu Li, Matthew Rea, Jianling Wang, Ruixin Wang, Jinghui Liu, Zhiguo Li, Chongli Yuan, Enze Liu, Yvonne N. Fondufe‐Mittendorf, Lang Li, Tao Han, Chi Wang, Xiaoqi Liu   +17 more
doaj   +1 more source

Differential Expression of Secretory Phospholipases A2 in Normal and Malignant Prostate Cell Lines: Regulation by Cytokines, Cell Signaling Pathways, and Epigenetic Mechanisms

Neoplasia: An International Journal for Oncology Research, 2008
Upregulation of group IIA phospholipase A2 (sPLA2-IIA) correlates with prostate tumor progression suggesting prooncogenic properties of this protein. Here, we report data on expression of three different sPLA2 isozymes (groups IIA, V, and X) in normal ...
Mario Menschikowski, Albert Hagelgans, Eugene Gussakovsky, Heike Kostka, Elena L Paley, Gabriele Siegert   +5 more
doaj   +1 more source

Emerging pro-drug and nano-drug strategies for gemcitabine-based cancer therapy

Asian Journal of Pharmaceutical Sciences, 2022
Gemcitabine has been extensively applied in treating various solid tumors. Nonetheless, the clinical performance of gemcitabine is severely restricted by its unsatisfactory pharmacokinetic parameters and easy deactivation mainly because of its rapid ...
Haijie Han, Su Li, Yueyang Zhong, Yue Huang, Kai Wang, Qiao Jin, Jian Ji, Ke Yao   +7 more
doaj   +1 more source

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia

Nature Communications, 2023
Cancer cells utilize the main de novo pathway and the alternative salvage pathway for deoxyribonucleotide biosynthesis to achieve adequate nucleotide pools.
Magali Saez-Ayala, Laurent Hoffer, Sébastien Abel, Khaoula Ben Yaala, Benoit Sicard, Guillaume P. Andrieu, Mehdi Latiri, Emma K. Davison, Marco A. Ciufolini, Paul Brémond, Etienne Rebuffet, Philippe Roche, Carine Derviaux, Edwige Voisset, Camille Montersino, Remy Castellano, Yves Collette, Vahid Asnafi, Stéphane Betzi, Patrice Dubreuil, Sébastien Combes, Xavier Morelli   +21 more
doaj   +1 more source

The prognostic value of cN-II and cN-III enzymes in adult acute myeloid leukemia

Haematologica, 2005
We analyzed the expression of deoxycytidine kinase (dCK), UMP/CMP-kinase (UMP/CMP-K), nucleotide diphosphokinase (NDPK-B) and 5'-nucleotidases cN-II, cN-III, cdN and mdN by quantitative polymerase chain reaction at diagnosis in leukemic blasts from 96 ...
CM Galmarini, E Cros, X Thomas, L Jordheim, C Dumontet   +4 more
doaj  

Exploring the Mutated Kinases for Chemoenzymatic Synthesis of N⁴-Modified Cytidine Monophosphates

Molecules
Nucleosides, nucleotides, and their analogues are an important class of molecules that are used as substrates in research of enzymes and nucleic acid, or as antiviral and antineoplastic agents. Nucleoside phosphorylation is usually achieved with chemical
Martyna Koplūnaitė, Kamilė Butkutė, Jonita Stankevičiūtė, Rolandas Meškys   +3 more
doaj   +1 more source

Extending Thymidine Kinase Activity to the Catalytic Repertoire of Human Deoxycytidine Kinase [PDF]

Biochemistry, 2009
Salvage of nucleosides in the cytosol of human cells is carried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1). Whereas TK1 is only responsible for thymidine phosphorylation, dCK is capable of converting dC, dA, and dG into their monophosphate forms.
Hazra, S., Sabini, E., Ort, S., Konrad, M., Lavie, A.   +4 more
openaire   +3 more sources

DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.

PLoS Biology, 2007
Affinity maturation and class switching of antibodies requires activation-induced cytidine deaminase (AID)-dependent hypermutation of Ig V(D)J rearrangements and Ig S regions, respectively, in activated B cells.
Adam J L Cook, Joanna M Raftery, K K Edwin Lau, Andrew Jessup, Reuben S Harris, Shunichi Takeda, Christopher J Jolly   +6 more
doaj   +1 more source