Evolution of herpesvirus thymidine kinases from cellular deoxycytidine kinase
Journal of General Virology, 1991 The thymidine kinases encoded by herpesviruses of higher vertebrates form a distinct group and are unrelated to the thymidine kinases (TKs) of other organisms. Their evolutionary source has not been identified, but our analysis has revealed a clear relationship with a sequence of human deoxycytidine kinase (dCK) published recently.
P T, Harrison, R, Thompson, A J, Davison
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The apoptotic effects of toosendanin are partially mediated by activation of deoxycytidine kinase in HL-60 cells. [PDF]
PLoS ONE, 2012 Triterpenoid toosendanin (TSN) exhibits potent cytotoxic activity through inducing apoptosis in a variety of cancer cell lines. However, the target and mechanism of the apoptotic effects by TSN remain unknown.
Jianming Ju +7 more
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Novel PET probes specific for deoxycytidine kinase. [PDF]
J Nucl Med, 2010 Deoxycytidine kinase (dCK) is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway and a critical determinant of therapeutic activity for several nucleoside analog prodrugs. We have previously reported the development of 1-(2'-deoxy-2'-(18)F-fluoro-beta-D-arabinofuranosyl)cytosine ((18)F-FAC), a new probe for PET of dCK activity in immune ...
Shu CJ +9 more
europepmc +4 more sources
The role of PAQR3 in cancer progression – Molecular regulation, signaling pathways, and clinical implications: A review [PDF]
Biomolecules & BiomedicineProgesterone and adiponectin receptor 3 (PAQR3) is a Golgi-localized seven-transmembrane protein that anchors rapidly accelerated fibrosarcoma kinase (Raf) and suppresses rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase ...
Yan Lv +4 more
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[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Arnon Lavie, Sam Sadeghi, Caius Radu
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The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death [PDF]
International Journal of Molecular Sciences, 2016 Xiaodong Liu, Nan Liang, Shumei Ma
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Correction: Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer [PDF]
Cell Death and DiseaseSuman Dash +5 more
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Structure-Function Relationship of Human deoxycytidine Kinase.
, 2010 Structure-Function Relationship of Human deoxycytidine ...
Saugata. Hazra (7957007)
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Scientific Reports, 2023 Deoxycytidine analogues (dCas) are widely used for the treatment of malignant diseases. They are commonly inactivated by cytidine deaminase (CDD), or by deoxycytidine monophosphate deaminase (dCMP deaminase).
Anna Ligasová +3 more
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Frontiers in Pharmacology, 2022 Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as a treatment option for various solid tumors. Although epigenome modulation provides a promising avenue in treating resistant cancer
Verona Buocikova +18 more
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