Results 41 to 50 of about 507,870 (221)
A general method for purification of deoxycytidine kinase [PDF]
Biochemical Journal, 1978 Deoxycytidine kinase from a variety of animal tissues binds to Cibacron Blue 3G-A coupled to Sepharose CL-6B. The enzyme can be selectively eluted with ATP to yield single-step purifications of 17-89-fold. The affinity adsorbent is re-usable.
A, Baxter, L M, Currie, J P, Durham
openaire +2 more sources
Ecotoxicology and Environmental Safety, 2021 Plants as sessile organisms have developed some unique strategies to withstand environmental stress and adaptive response (AR) is one of them. In the present study Cadmium (Cd)-induced AR was evaluated to ameliorate the genotoxicity of a known chemical ...
Manoswini Chakrabarti, Anita Mukherjee
doaj +1 more source
PRKCDBP Methylation is a Potential and Promising Candidate Biomarker for Non-small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2022 Background and objectives: The occurrence and development of lung cancer are closely linked to epigenetic modification. Abnormal DNA methylation in the CpG island region of genes has been found in many cancers.
Jing LI +8 more
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mSphere, 2019 Cytidine deaminase (CDA) is a pyrimidine salvage enzyme that catalyzes cytidine and deoxycytidine hydrolytic deamination to yield uridine and deoxyuridine.
Ana Moro-Bulnes +6 more
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Preventive electroacupuncture reduces cognitive deficits in a rat model of D-galactose-induced aging
Neural Regeneration Research, 2021 Acupuncture can reduce cognitive deficits in Alzheimer’s disease. However, whether electroacupuncture can prevent or alleviate the cognitive deficits in animal models of aging remains poorly understood.
Chao-Chao Yu +10 more
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, 2011 Deoxycytidine analogs are an important class of clinically active antiviral and anticancer agents. The stepwise phosphorylation of these analogs to triphosphate metabolites is crucial for biological action.
劉界元;徐志宏;張瑋玲;黃煜珺;鄭永齊 +1 more
core +2 more sources
Human deoxycytidine kinase is located in the cell nucleus [PDF]
Proceedings of the National Academy of Sciences, 1997 Human deoxyribonucleoside kinases are required for the pharmacological activity of several clinically important anticancer and antiviral nucleoside analogs. Human deoxycytidine kinase and thymidine kinase 1 are described as cytosolic enzymes in the literature, whereas human deoxyguanosine kinase and thymidine kinase 2 are believed ...
M, Johansson, S, Brismar, A, Karlsson
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International Journal of Preventive Medicine, 2021 Background: The cell cycle is divided into four phases, G1, G2, S, and M phase. The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin and the cyclin-dependent kinase (CDK), cyclin-CDK complexes.
Masumeh Sanaei +2 more
doaj +1 more source
Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC-MS/MS. [PDF]
Biomed ChromatogrABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Deppas JJ +5 more
europepmc +2 more sources
Preclinical development of non-viral gene therapy for patients with advanced pancreatic cancer
Molecular Therapy: Methods & Clinical Development, 2023 Pancreatic cancer remains one of the greatest challenges in oncology for which therapeutic intervention is urgently needed. We previously demonstrated that the intra-tumoral gene transfer of somatostatin receptor 2, to combat tumor aggressiveness, or of ...
Odile Barbey +9 more
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